Pilot3 D7.1 - Dissemination, communication and exploitation plan

This document is the Communication, Dissemination and Exploitation Plan (D7.1) of the Clean Sky 2 Innovation Action Pilot3. The document defines the communication and dissemination actions to be performed during the project, and the potential exploitation of the project results. A complete strategy of communication is presented, as well as the items and content already prepared for it

Variation of the ultraviolet extinction law across the Taurus-Auriga star forming complex. A GALEX based study

The Taurus-Auriga molecular complex (TMC) is the main laboratory for the study of low mass star formation. The density and properties of interstellar dust are expected to vary across the TMC. These variations trace important processes such as dust nucleation or the magnetic field coupling with the cloud. In this article, we show how the combination of near ultraviolet (NUV) and infrared (IR) photometry can be used to derive the strength of the 2175 \AA\ bump and thus any enhancement in the abundance of small dust grains and PAHs in the dust grains size distribution. This technique is applied to the envelope of the TMC, mapped by the GALEX All Sky Survey (AIS). UV and IR photometric data have been retrieved from the GALEX-AIS and the 2MASS catalogues. NUV and K-band star counts have been used to identify the areas in the cloud envelope where the 2175 \AA\ bump is weaker than in the diffuse ISM namely, the low column density extensions of L1495, L1498 and L1524 in Taurus, L1545, L1548, L1519, L1513 in Auriga and L1482-83 in the California region. This finding agrees with previous results on dust evolution derived from Spitzer data and suggests that dust grains begin to decouple from the environmental galactic magnetic field already in the envelope.Comment: Accepted in Monthly Notices of the Royal Astronomical Societ

Engage D3.7 Update on the Engage repository and knowledge hub functionality (initial)

This initial report describes the planned functionality and features of the forthcoming Engage wiki and establishes the scope of the ATM concepts roadmap

Dispatcher3 D7.1 - Project communication, dissemination and exploitation plan

This document is the Communication, Dissemination and Exploitation Plan (D7.1) of the Clean Sky 2 Innovation Action Dispatcher3. The document defines the communication and dissemination actions to be performed during the project, and the potential exploitation of the project results. A complete strategy of communication is presented, as well as the items and content already prepared for it

Engage D2.1 Communication plan, website, and visual identity material

The purpose of this document, Deliverable 2.1, is to describe the dissemination plan, dissemination policy and initial dissemination products of the SESAR 2020 Exploratory Research action Engage, taking into account its specifications and the target audience. The following pages document the corresponding tasks involved in D2.1

Engage D2.2 Final Communication and Dissemination Report

This deliverable reports on the communication and dissemination activities carried out by the Engage consortium over the duration of the network. Planned activities have been adapted due to the Covid-19 pandemic, however a full programme of workshops and summer schools has been organised. Support has been given to the annual SESAR Innovation Days conference and there has been an Engage presence at many other events. The Engage website launched in the first month of the network. This was later joined by the Engage ‘knowledge hub’, known as the EngageWiki, which hosts ATM research and knowledge. The wiki provides a platform and consolidated repository with novel user functionality, as well as an additional channel for the dissemination of SESAR results. Engage has also supported and publicised numerous research outputs produced by PhD candidates and catalyst fund projects

Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice

Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients. We hypothesize that specific Fcγ receptors for IgG constant region participate in atherogenesis by regulating the inflammatory state of lesional macrophages. In vivo we examined the role of activating Fcγ receptors in atherosclerosis progression using bone marrow transplantation from mice deficient in γ-chain (the common signaling subunit of activating Fcγ receptors) to hyperlipidemic mice. Hematopoietic deficiency of Fcγ receptors significantly reduced atherosclerotic lesion size, which was associated with decreased number of macrophages and T lymphocytes, and increased T regulatory cell function. Lesions of Fcγ receptor deficient mice exhibited increased plaque stability, as evidenced by higher collagen and smooth muscle cell content and decreased apoptosis. These effects were independent of changes in serum lipids and antibody response to oxidized low-density lipoproteins. Activating Fcγ receptor deficiency reduced pro-inflammatory gene expression, nuclear factor-κB activity, and M1 macrophages at the lesion site, while increasing anti-inflammatory genes and M2 macrophages. The decreased inflammation in the lesions was mirrored by a reduced number of classical inflammatory monocytes in blood. In vitro, lack of activating Fcγ receptors attenuated foam cell formation, oxidative stress and pro-inflammatory gene expression, and increased M2-associated genes in murine macrophages. Our study demonstrates that activating Fcγ receptors influence the macrophage phenotypic balance in the artery wall of atherosclerotic mice and suggests that modulation of Fcγ receptor-mediated inflammatory responses could effectively suppress atherosclerosis