Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation

The NF-κB/REL-family of transcription factors plays a central role in coordinating the expression of a wide variety of genes controlling immune responses including autoimmunity of the central nervous system (CNS). The inactive form of NF-κB consists of a heterodimer which is complexed with its inhibitor, IκB. Conditional knockout-mice for IκBα in myeloid cells (lysMCreIκBαfl/fl) have been generated and are characterized by a constitutive activation of NF-κB proteins allowing the study of this transcription factor in myelin-oligodendrocyte-glycoprotein induced experimental autoimmune encephalomyelitis (MOG-EAE), a well established experimental model for autoimmune demyelination of the CNS

The role of public funding in nanotechnology scientific production: Where Canada stands in comparison to the United States

This paper presents cross-country comparisons between Canada and the United States in terms of the impact of public grants and scientific collaborations on subsequent nanotechnology-related publications. In this study we present the varying involvement of academic researchers and government funding to capture the influence of funded research in order to help government agencies evaluate their efficiency in financing nanotechnology research. We analyze the measures of quantity and quality of research output using time-related econometric models and compare the results between nanotechnology scientists in Canada and the United States. The results reveal that both research grants and the position of researchers in co-publication networks have a positive influence on scientific output. Our findings demonstrate that research funding yields a significantly positive linear impact in Canada and a positive non-linear impact in the United States on the number of papers and in terms of the number of citations we observe a positive impact only in the US. Our research shows that the position of scientists in past scientific networks plays an important role in the quantity and quality of papers published by nanotechnology scientists