1,910 research outputs found
Therapeutic music experiences for college-aged women with negative body perception
2013 Spring.Includes bibliographical references.Body image disturbances and maladjusted compensatory eating behaviors are a problem which affects a significant portion of the population, especially young women. These issues can lead to an eating disorder, a life-threatening psychological disease that manifests physically. Research indicates that recovery from an eating disorder is extremely difficult but possible through a variety of medical, nutritional, psychological, and creative therapies. One creative therapy that has been successfully utilized by clinicians is music therapy. However, there is a limited amount of information published regarding therapeutic music's efficacy in treating body image and eating troubles. The purpose of this pilot study was to gather initial efficacy data on a variety of therapeutic music interventions in improving self-image through a descriptive case-study. Participants consisted of six female students between the ages of 18 and 25 years recruited from the Colorado State University campus. Subjects took part in at least three out of five one hour sessions that occurred for a period of five consecutive days. Music interventions included music directed progressive relaxation, movement and breathing to music, improvisation, music leading, lyric analysis, and therapeutic song writing. Data was collected blindly through a questionnaire prepared by the researcher as well as a pre-test post-test comparison of the Tennessee Self-Concept Scale. Data was analyzed with a paired t-test with the independent variable of participation in the music intervention and the dependent variable being the score received on the Tennessee Self-Concept Scale. Because of the low number of participants and the absence of a control group, alpha was set at p<0.10. The calculated t-score of the total score on the Tennessee Self-Concept Scale was p = 0.133 and the null hypothesis was therefore not rejected and significance not reached. However, three of the four participants on which data was collected showed improvement in total score with the fourth participant showing no change. Further, all participants improved in the specific area of physical self-concept, reaching significance with a calculated t-score of p=0.089. Finally, responses on the post-test questionnaire indicated that participants enjoyed taking part in the therapeutic music interventions and felt as though they had received some benefit from taking part in sessions
Eine präzise Multilevel-Testbench zur Systemsimulation und Charakterisierung einer 2,5 GHz PLL
In diesem Aufsatz wird eine präzise Multilevel-Testbench zur PLL-Charakterisierung vorgestellt. Die Schwerpunkte dieses Beitrags sind einerseits das 10 GHz VCO-Design und andererseits die vorhersagefähigen Ergebnisse der mit Hilfe dieses Multilevelansatzes durchgeführten PLL-Systemsimulationen. <br><br> Bei dem VCO-Design wurden folgende Ergebnisse erreicht: Abstimmbereich &asymp;26% bzw. kvco&asymp;1300 MHz/V, Phasenrauschen PN=&ndash;101,4 dBc/Hz @1 MHz Offset vom 10 GHz Träger, Leistungsverbrauch = 5,5 mW. Als realistisches Demonstrationsbeispiel ist das &#0132;analog mixed signal&#0147;-Verhalten eines 2,5 GHz PLL-Systems für &#0132;dual-conversion&#0147;-Strukturen bei IEEE 802.11a WLAN-Anwendungen gewählt worden. Für dieses Beispiel wird eine effiziente PLL-Modellierung kritischer PLL-Blöcke (Frequenzteiler und Phasenfrequenzdetektor) auf der Basis der PSS-Analyse und neuer Verilog-A/MS Befehle demonstriert. Die dabei verwendete Testbench kann im Prinzip in verschiedenen aktuellen Wireless Kommunikationssystemen bis 10 GHz wieder verwendet werden (Reuse-IP). Dieser Ansatz führt einerseits zur Verbesserung der Simulationszeiten (verglichen mit dem Transistorlevel) und andererseits zu genaueren und realistischeren Ergebnissen, vor allem am VCO-Ausgang (verglichen mit dem HDL-Level)
Teaching old NCATs new tricks: using non-canonical amino acid tagging to study neuronal plasticity
The non-canonical amino acid labeling techniques BONCAT (bioorthogonal non-canonical amino acid tagging) and FUNCAT (fluorescent non-canonical amino acid tagging) enable the specific identification and visualization of newly synthesized proteins. Recently, these techniques have been applied to neuronal systems to elucidate protein synthesis dynamics during plasticity, identify stimulation-induced proteomes and subproteomes and to investigate local protein synthesis in specific subcellular compartments. The next generation of tools and applications, reviewed here, includes the development of new tags, the quantitative identification of newly synthesized proteins, the application of NCAT to whole animals, and the ability to genetically restrict NCAT labeling. These techniques will enable not only improved detection but also allow new scientific questions to be tackled
An application of high-dimensional statistics to predictive modeling of grade variability
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The economic viability of a mining project depends on its efficient exploration, which requires a prediction of worthwhile ore in a mine deposit. In this work, we apply the so-called LASSO methodology to estimate mineral concentration within unexplored areas. Our methodology outperforms traditional techniques not only in terms of logical consistency, but potentially also in costs reduction. Our approach is illustrated by a full source code listing and a detailed discussion of the advantages and limitations of our approach
Orientation of native versus translocated juvenile lesser spotted eagles <i>(Clanga pomarina)</i> on the first autumn migration
The ontogeny of migration routines used by wild birds remains unresolved. Here we investigated the migratory orientation of juvenile lesser spotted eagles (LSE; Clanga pomarina) based on translocation and satellite tracking. Between 2004 and 2016, 85 second-hatched juveniles (Abels) were reared in captivity for release into the declining German population, including 50 birds that were translocated 940 km from Latvia. In 2009, we tracked 12 translocated juveniles, as well as eight native juveniles and nine native adults, to determine how inexperienced birds come to use strategic migration routes. Native juveniles departed around the same time as the adults and six of eight used the eastern flyway around the Mediterranean, which was used by all adults. In contrast, translocated juveniles departed on average 6 days before native LSEs, and five travelled southward and died in the central Mediterranean region. Consequently, fewer translocated juveniles (4/12) than native juveniles (7/8) reached Africa. We conclude that juvenile LSEs have a much better chance of learning the strategic southeastern flyway if they leave at an appropriate time to connect with experienced elders upon departure. It is not clear why translocated juveniles departed so early. Regardless, by the end of the year, most juveniles had perished, whether they were translocated (10/12) or not (6/8). The small number of surviving translocated juveniles thus still represents a significant increase in the annual productivity of the German LSE population in 2009
Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.
G-protein-coupled-receptors (GPCRs) are of fundamental importance for signal transduction through cell membranes. This makes them important drug targets, but structure-based drug design (SBDD) is still hampered by the limitations for structure determination of unmodified GPCRs. We show that the interligand NOEs for pharmacophore mapping (INPHARMA) method can provide valuable information on ligand poses inside the binding site of the unmodified human A2A adenosine receptor reconstituted in nanodiscs. By comparing experimental INPHARMA spectra with back-calculated spectra based on ligand poses obtained from molecular dynamics simulations, a complex structure for A2A R with the low-affinity ligand 3-pyrrolidin-1-ylquinoxalin-2-amine was determined based on the X-ray structure of ligand ZM-241,358 in complex with a modified A2A R
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