Perbandingan Derajat Keparahan Acne Vulgaris pada Pasien yang Menjalani Superficial Chemical Peeling di Klinik Kecantikan di Batubulan, Gianyar

Acne vulgaris is a skin disease that is often found in women. Various kinds of treatment are given to sufferers of acne vulgaris to cure and get rid of acne. Currently, the therapy that is being intensively used to cure acne vulgaris is chemical peels. Giving chemical peels is believed to reduce acne scars and inflammatory and non-inflammatory lesions, improve depigmentation, and eliminate scar tissue caused by acne. The purpose of this study was to compare the severity of acne vulgaris based on the frequency and regularity of patients undergoing superficial chemical peels at the Batubulan beauty clinic, Gianyar. This research is a descriptive study with a cross sectional approach. The research population used was acne vulgaris sufferers who underwent treatment at a beauty clinic in Batubulan, Gianyar, with a total of 34 samples. The results showed that most of the patients who underwent superficial chemical peels at the Batubulan beauty clinic, Gianyar were women aged 17-30 years with a frequency of 6-12 superficial chemical peels, 17 people (50.0%), 13 people-24 times, 15 times. people (44.1%), and >24 times as many as 2 people (5.9%) which was done once a month by 12 people (35.3%) and twice a month by 22 people (64.7%) with mild degrees 28 people (82.4%) and 6 people (17.6%). Patients with a mild degree of acne mostly underwent superficial chemical peels 6-24 times and patients with mild degrees of acne mostly underwent superficial chemical peels twice a month.Acne vulgaris merupakan penyakit kulit yang sering dijumpai pada perempuan. Berbagai macam pengobatan diberikan kepada penderita acne vulgaris untuk menyembuhkan dan menghilangkan acne. Salah satu terapi yang sedang gencar digunakan saat ini dalam menyembuhkan acne vulgaris adalah chemical peeling. Pemberian chemical peeling dipercaya dapat mengurangi bekas acne, mengurangi lesi inflamasi dan non-inflamasi, memperbaiki dispigmentasi, dan menghilangkan jaringan parut akibat acne. Penelitian ini bertujuan untuk mengetahui perbandingan derajat keparahan acne vulgaris berdasarkan frekuensi dan keteraturan pasien yang menjalani superficial chemical peeling di klinik kecantikan di Batubulan, Gianyar. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Populasi penelitian yang digunakan adalah penderita acne vulgaris yang melakukan perawatan di klinik kecantikan di Batubulan, Gianyar yang berjumlah 34 sampel. Hasil penelitian didapatkan sebagian besar pasien yang menjalani superficial chemical peeling di klinik kecantikan di Batubulan, Gianyar adalah perempuan berusia 17-30 tahun dengan frekuensi pemberian superficial chemical peeling selama 6-12 kali sebanyak 17 orang (50.0%), 13-24 kali sebanyak 15 orang (44.1%), dan >24 kali sebanyak 2 orang (5.9%) yang dilakukan sebulan sekali sebanyak 12 orang (35.3%) dan sebulan dua kali sebanyak 22 orang (64.7%) dengan hasil derajat ringan 28 orang (82.4%) dan sedang 6 orang (17.6%). Pasien dengan derajat acne ringan sebagian besar menjalani superficial chemical peeling sebanyak 6-24 kali dan pasien dengan derajat acne ringan sebagian besar menjalani superficial chemical peeling selama sebulan dua kali

Phytochemical Analysis and Molecular Identification of Green Macroalgae <i>Caulerpa</i> spp. from Bali, Indonesia

The studies of the Bulung Boni and Bulung Anggur (Caulerpa spp.) species and secondary metabolites are still very limited. Proper identification will support various aspects, such as cultivation, utilization, and economic interests. Moreover, understanding the secondary metabolites will assist in developing algae-based products. This study aimed to identify these indigenous Caulerpa algae and analyze their bioactive components. The tufA sequence was employed as a molecular marker in DNA barcoding, and its bioactive components were identified using the GC-MS method. The phylogenetic tree was generated in MEGA 11 using the maximum likelihood method, and the robustness of the tree was evaluated using bootstrapping with 1000 replicates. This study revealed that Bulung Boni is strongly connected to Caulerpa cylindracea. However, Bulung Anggur shows no close relationship to other Caulerpa species. GC-MS analysis of ethanolic extracts of Bulung Boni and Bulung Anggur showed the presence of 11 and 13 compounds, respectively. The majority of the compounds found in these algae have been shown to possess biological properties, such as antioxidant, antibacterial, anticancer, anti-inflammation, and antidiabetic. Further study is necessary to compare the data obtained using different molecular markers in DNA barcoding, and to elucidate other undisclosed compounds in these Caulerpa algae