Characterisation and outcome of idiopathic pyogranulomatous lymphadenitis in 64 English springer spaniel dogs

Objectives To describe the history, clinicopathological abnormalities, diagnostic imaging findings, lymph node cytological/histological appearance, treatment and outcome of English springer spaniels diagnosed with idiopathic pyogranulomatous lymphadenitis. Materials and Methods In this retrospective UK‐based multicentre study, 64 dogs were recruited from 10 referral centres, 32 first‐opinion practices and three histopathology/cytology laboratories, between 2010 and 2016. Results The median age at presentation was 6 years (range: 0.17 to 11.75). Neutered females were frequently affected. Pyrexia (83.8%), peripheral lymphadenomegaly (78.4%), dermatological lesions (72.9%), lethargy (67.6%), hyporexia (54%), diarrhoea (29.7%), coughing (24.3%), epistaxis, sneezing or nasal discharge (21.6%), ocular signs (21.6%) and vomiting (16.2%) were reported in dogs for which the history and physical examination records were available. Popliteal (45.3%), superficial cervical (35.9%) and submandibular (37.5%) lymphadenomegaly were frequently reported. Haematology and serum biochemistry revealed non‐specific changes. When undertaken, testing for infectious diseases was negative in all cases. Lymph node cytology, histopathology or both demonstrated mixed inflammatory (27%), pyogranulomatous (24%), neutrophilic (20%) or granulomatous (11%) lymphadenitis. Treatment details were available for 38 dogs, with 34 receiving prednisolone for a median duration of 15 weeks (range: 1 to 28 weeks). A good to excellent clinical response was reported in all but one case. Ten dogs relapsed after discontinuing prednisolone. Clinical Significance Idiopathic pyogranulomatous lymphadenitis should be considered as a differential diagnosis for lymphadenopathy and pyrexia in English springer spaniels. The characteristics of the disease, absence of identifiable infectious aetiology and response to glucocorticoid therapy suggest an immune‐mediated aetiology

Decentralised and Collaborative Auditing of Workflows

Workflows involve actions and decision making at the level of each participant. Trusted generation, collection and storage of evidence is fundamental for these systems to assert accountability in case of disputes. Ensuring the security of audit systems requires reliable protection of evidence in order to cope with its confidentiality, its integrity at generation and storage phases, as well as its availability. Collusion with an audit authority is a threat that can affect all these security aspects, and there is room for improvement in existent approaches that target this problem. This work presents an approach for workflow auditing which targets security challenges of collusion-related threats, covers different trust and confidentiality requirements, and offers flexible levels of scrutiny for reported events. It relies on participants verifying each other's reported audit data, and introduces a secure mechanism to share encrypted audit trails with participants while protecting their confidentiality. We discuss the adequacy of our audit approach to produce reliable evidence despite possible collusion to destroy, tamper with, or hide evidence

Dysautonomia in 53 cats and dogs: A retrospective review of clinical data and outcome

The aim of this study was to perform a retrospective multicentre review of clinical data relating to cats and dogs diagnosed with dysautonomia and to evaluate their outcome