Textual representations of the socio-urban history of Baghdad : critical approaches to the historiography of Baghdad in the 18th and 19th centuries

This thesis focuses on historiography, which is the study of history and methodology of the discipline of history. The problems of historical theory and the role of critical theory in historical understanding are the main objectives of this study. The thesis explores the urban history of Baghdad in the eighteenth and nineteenth centuries, to posit alternative historiographical methods that involve non-conventional textual representations as historical evidence. These textual representations include poetry, travelogues and narratives around non-monumental everyday urban places, all of which are often ignored in conventional history writing. Conventional approaches to historiography are normally single-layered and limited, and contain gaps or ‘absences’ of distinctive local historical themes and spaces that are smoothed over by grand narratives. The alternative method in historiography suggested in this thesis emphasises the need for closer ties between history and literary criticism. It interprets literature in relation to knowledge, and it discloses their philosophical connections to the ‘overlooked’ meanings in urban history. Although the alternative method comprises strong links to literary analysis, the thesis seeks a combination of both scientific and speculative philosophies, and an addition of extra concepts, towards the generation of specific historiographical concepts and themes. Baghdad provides an excellent vehicle to investigate the general problem of historiography, with its complex history of conquest and colonisation, its long history of creative writings and the vague representation of its urban spaces in current historiographical studies. Although this thesis explored the entire history of Baghdad, the period of interest is the Mamluk period between mid-eighteenth and mid-nineteenth centuries. In addition to the transformation and change that shaped Baghdad’s urban history, this period significantly produced rich poetry and historical narratives that embraced plentiful themes of the urban development of the city, which have been overlooked in conventional historiography. These themes include the measures of beauty of Baghdad, the attractive and interlocking qualities of the Tigris River, Karkh region and markets, the multiple meanings of gardens and learning centres, and the social and leisure significance of houses. The thesis focuses on the poetry of the prominent scholar and poet Sheikh Kadhem Al-Uzari, the historian and religious scholar Sheikh Abdul-Rahman Al-Suwaidi, and the poet and chief of the writing bureau in Baghdad Sheikh Saleh Al-Tamimi, in addition to a number of texts by other scholars in that period. The thesis also focuses on the travelogues of mainly four travelers who wrote significant observations of Baghdad during this period, namely; the surveyor Carsten Niebuhr, the entomologist Guillaume Antoine Olivier, the British resident Claudius Rich and the traveler and writer James Silk Buckingham.The thesis also refers to the writings of philosophers such as Edward Said, Hans Georg Gadamer and Michel Foucault for philosophical frameworks to outline the alternative method of interpretation of these texts. The analysis of poetry and narratives composed by Baghdadis in the eighteenth and nineteenth centuries, and of travelogues of the same period, is ‘another’ method in historiography that is intended to support and complement the existing understanding of the city’s history, and to attain a more dialogical interface with the past. In this way, historiography becomes a more critical influential discipline in historical studies

Molecular interaction of 4-amino-N’-(benzoyloxy)-N-(2,4- dimethylphenyl)-1,2,5-oxadiazole-3-carboximidamide with the methotrexate binding site of human DHFR, and its implication in rheumatoid arthritis

Purpose: To identify an improved lead molecule for the human dihydrofolate reductase (DHFR) inhibition that ‘sits’ in the same binding cavity as methotrexate by high throughput computationalscreening.Methods: The 3-D structure of the DHFR binding site was examined using ‘CASTp3.0’. Structure based in silico screening of about 5 million drug candidates housed in the MCULE database was performed. The obtained molecule-hits were ranked in accordance with their VINA scores, made to pass through drug-likeness filters, ΔG cut-off criterion, toxicity-checker and finally ‘zero RO5 criterion’.Results: The ‘top molecule’, namely, 4-amino-N'-(benzoyloxy)-N-(2,4-dimethylphenyl)-1,2,5-oxadiazole- 3-carboximidamide, displayed robust binding with human DHFR through 21 amino acid residues (ΔG = - 9.6 kcal/mol) while 10 of these residues were the same as those displayed by ‘methotrexate binding interactions’. It passed through relevant drug screening filters including the ‘Toxicity Checker’.Conclusion: This research work describes the molecular interaction of human DHFR with an improved lead molecule named, 4-amino- N’-(benzoyloxy)-N-(2,4-dimethylphenyl)-1,2,5-oxadiazole-3- carboximidamide, with a ΔG of -9.6 kcal/mol, thus satisfying adequate ADME features for further in vitro and in vivo validation in the context of rheumatoid arthritis. Keywords: Dihydrofolate reductase, In silico screening, Methotrexate, Rheumatoid arthritis, DHF

Identification of a putative anti-rheumatoid arthritis molecule by virtual screening

Purpose: To propose an improved chemical skeleton whose scaffolds could be used for the design of future thymidylate synthase (TS)-inhibitors against rheumatoid arthritis. Methods: The drug discovery platform, ‘MCULE’, was employed for inhibitor-screening. The ‘methotrexate-interaction site’ in the crystal (PDB ID 5X66) was used as a target. One ‘RO5 violation’ was permitted. A maximum of ‘10 rotatable bonds’ and ‘100 diverse molecules’ were also allowed in the protocol. The ‘threshold similarity cut off’ was 0.7. The input values describing the remaining parameters were kept as ‘default’. The ‘Open Babel Linear Fingerprint’ was used for the analyses of molecular descriptors, followed by ADME-check. Results: 4-(4-Methyl-1-piperazinyl)-2-phenyl[1]benzofuro[3,2-d]pyrimidine corresponding to the MCULE ID-7590816301-0-93 exhibited the overall best binding with TS. The free energy of binding was -8.6 kcal/mol. A total of 17 amino acid residues were significant for the binding interactions. Importantly, 9 residues were common to methotrexate binding. It satisfied pertinent ADME conditions. Conclusion: 4-(4-Methyl-1-piperazinyl)-2-phenyl[1]benzofuro[3,2-d]pyrimidinemay emerge as a potent seed molecule for TS-inhibitor design in the context of rheumatoid arthritis. It has satisfied pertinent ADME features. However, there is need for further wet laboratory validation. Keywords: Anti-rheumatoid arthritis, Inhibitor design, Methotrexate, Seed molecule, Thymidylate synthase, Virtual screenin

Physical and Chemical Characterization of Kuwaiti Atmospheric Dust and Synthetic Dusts: Effects on the Pressure Drop and Fractional Efficiency of HEPA Filters

The importance of clean air to the indoor air quality affecting the well-being of human occupants and rising energy consumption has highlighted the critical role of air filter performance. Actual performance of air filters installed in air handling units in Kuwait tends to deviate from the performance predicted by laboratory results. Therefore, accurate filter performance prediction is important to estimate filter lifetime, and to reduce energy and maintenance operating costs. To ensure appropriate filter selection for a specific application, particulate contaminants existing in the Kuwaiti atmospheric dust were identified and characterized both physically and chemically and compared to the synthetic dust used in laboratories. This paper compares the physical and chemical characterization Kuwaiti atmospheric dust with the available commercial synthetic dusts. It also tests full scale HEPA pleated V-shaped filters used in Heating Ventilation and Air Conditioning (HVAC) and gas turbine applications to study the effect of different synthetic dust types and their particle size distributions on the pressure drop and fractional efficiency using DEHS testing according to DIN 1822

Optimising concrete containing palm oil clinker and palm oil fuel ash using response surface method

Cement production led to the consumption of high energy and generated harmful gases, such as CO2. Therefore, the use of alternative materials becomes necessary. The research attempts to use palm oil clinker (POC) and ultrafine palm oil fuel ash (UPOFA) as a full replacement of coarse aggregate and partial cement replacement, respectively. This study aims to use the response surface method (RSM) to optimise the properties of concrete, namely, density and water absorption. The study investigated the density and water absorption of concrete using RSM. Results showed that the density reduced sharply owing to the full replacement coarse aggregate by POC aggregate. Meanwhile, water absorption increased significantly due to the rise in the POC aggregate replacement. However, water absorption decreased because of the use of UPOFA as cement replacement. The study recommended the use of more UPOFA as cement replacement because of its high pozzolanic property

Dimensional accuracy of Electron Beam Melting (EBM) additive manufacture with regard to weight optimized truss structures

The Electron Beam (EBM) additive manufacturing process is well suited to fabricating complex structural designs in Ti–6Al–4V because of the design freedoms it offers combined with strong and consistent material properties. However it has been observed that complications may arise when manufacturing truss-like structures (such as those produced via structural topology optimization) in the form of undersized features on the finished part. The issue appears to affect truss members that are not aligned with the vertical build direction, with an apparent lack of material on the negative surfaces. This effect appears to worsen with a greater angle between the truss member and the build direction, even with the use of support structures. This investigation has characterized and measured the dimensional errors that result from this issue through 3D scanning techniques. Process modifications have then been made which result in significant improvements in dimensional accuracy. This investigation highlights the importance of heat management at features with negative surfaces to yield parts that are dimensionally accurate without introducing excessive internal melt defects in the form of voids and porosity

Production of 1-Butyl-3-Methylimidazolium Acetate [Bmim][Ac] Using 1-Butyl-3-Methylimidazolium Chloride [Bmim]Cl and Silver Acetate: A Kinetic Study

Since most of the literature alternatives used to produce the ionic liquid 1-butyl-3-methylimidazolium acetate [Bmim][Ac] are very slow and require different solvents, we have used in this work a new process to produce the [Bmim][Ac] by the reaction of the ionic liquid 1-butyl-3-methylimidazolium chloride [Bmim]Cl with silver acetate (AgAc) where silver chloride (AgCl) precipitates as a by-product. The genuine experimental work and kinetic analyses presented here indicate that the reaction rate constant k = 7.67x1012 e(−79.285/RT). That is, the Arrhenius constant ko = 7.67x1012 L/mol.s and the activation energy Ea = 79.285 kJ/mol. The very high value of the Arrhenius constant indicates that the reaction of [Bmim]Cl with silver acetate to produce [Bmim][Ac] and silver chloride is extremely fast

How the other half lives: CRISPR-Cas's influence on bacteriophages

CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers are expressed as mobile surveillance RNAs that direct CRISPR-associated (Cas) proteins to protect against subsequent attack by the same phages or plasmids. The threat from mobile genetic elements inevitably shapes the CRISPR loci of archaea and bacteria, and simultaneously the CRISPR-Cas immune system drives evolution of these invaders. Here we highlight our recent work, as well as that of others, that seeks to understand phage mechanisms of CRISPR-Cas evasion and conditions for population coexistence of phages with CRISPR-protected prokaryotes.Comment: 24 pages, 8 figure

Improved outcome in children with advanced stage B-cell non-Hodgkin's lymphoma (B-NHL): results of the United Kingdom Children Cancer Study Group (UKCCSG) 9002 protocol

From July 1990 to March 1996, 112 children with stage III or IV B-cell non-Hodgkin's lymphoma (B-NHL) with up to 70% FAB L3-type blasts (n= 42) in the bone marrow without central nervous system (CNS) disease were treated on the United Kingdom Children Cancer Study Group (UKCCSG) 9002 protocol (identical to the French LMB 84). The median age was 8.3 years. There were 81 boys and 31 girls. According to the extent of the primary disease, patients were sub-staged into three groups: IIIA with unresectable abdominal tumour (n= 39); IIIB with abdominal multiorgan involvement (n= 57) and IIIX with extra-abdominal primary lymphoma often presenting as pleural effusion (n= 16). Univariate and multivariate analyses were carried out to evaluate the prognostic significance of lactate dehydrogenase (LDH) level at diagnosis, the sub-stage and the time to achieve complete remission (CR). With a median follow up of 48 months (range 12–92), the overall and event free survival (EFS) is 87% (95% confidence interval (CI) 79.2–92.1%) and 83.7% (95% CI 76.3–89.2%) respectively. Six patients (5.4%) never achieved CR, of whom one is alive following high-dose therapy. Eight patients (7.1%) relapsed after achieving CR, three are alive after second-line therapy. There were three early toxic deaths (2.7%), mainly from infection, and one late death from a second cancer. There was no significant difference in EFS according to LDH level at diagnosis, the sub-stage or the time to CR. This study confirms the overall good prognosis and low rate of toxic deaths in patients with advanced B-NHL treated with this intensive regimen. No significant difference in EFS according to the sub-stage, the time to achieve CR or LDH level at diagnosis making it difficult to identify a group that should not receive intensive therapy. © 2000 Cancer Research Campaig

Identification and support of autistic individuals within the UK Criminal Justice System: a practical approach based upon professional consensus with input from lived experience.

Background: Autism Spectrum Disorder (hereafter referred to as autism) is characterised by difficulties with (i) social communication, social interaction, and (ii) restricted and repetitive interests and behaviours. Estimates of autism prevalence within the criminal justice system (CJS) vary considerably, but there is evidence to suggest that the condition can be missed or misidentified within this population. Autism has implications for an individual’s journey through the CJS, from police questioning and engagement in court proceedings through to risk assessment, formulation, therapeutic approaches, engagement with support services, and long-term social and legal outcomes. Methods: This consensus based on professional opinion with input from lived experience aims to provide general principles for consideration by United Kingdom (UK) CJS personnel when working with autistic individuals, focusing on autistic offenders and those suspected of offences. Principles may be transferable to countries beyond the UK. Multidisciplinary professionals and two service users were approached for their input to address the effective identification and support strategies for autistic individuals within the CJS. Results: The authors provide a consensus statement including recommendations on the general principles of effective identification, and support strategies for autistic individuals across different levels of the CJS. Conclusion: Greater attention needs to be given to this population as they navigate the CJS