962 research outputs found

    Effects of Generational Cohorts on Brand-Self Congruity, Emotional Brand Attachment, Perceived Investment, and Repurchase Behavior regarding Luxury Goods

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    The global luxury market reached €223 billion in sales in 2014 (Bain & Company, 2014). There are various factors surrounding the behavior of luxury consumption, such as emotional brand attachment, brand-self congruity, perceived investment, and repurchase intentions. This study investigated influences of generational cohorts—older BB, younger BB, generation X, and Millennials—on consumer trait variables introduced earlier and repurchase intentions of luxury goods among affluent US consumers to offer insights regarding the variances and/or similarities among the cohorts to the luxury marketing and retail industries

    Generational Cohort Comparisons of Clothing Disposal and Hoarding Behaviors

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    This research employs generational cohort theory and compares post-purchase behaviors of fashion items among three generational groups: Millennials, Generation Xers, and Baby Boomers. A nationwide representative sample (441 respondents) completed a self-administered online survey; Millennials (n = 112), generation Xers (n = 115), and baby boomers (n = 214). Results of Multivariate Analysis of Variance indicated statistically significant mean differences on hoarding tendencies and participation in textile recycling, whereas no differences were found in numbers of discarding and percent of unworn items in the closet among the three groups. Baby boomers are less likely participate in clothing recycling and hoarding tendencies than both generation Xers and Millennials. Regardless of generations, overall, the respondent showed a high level of discarding behavior; throwing away about 10 fashion items per year and kept 20%-30% of unworn fashion items in their closet

    Necklace-like microvacuoles of tumor cells in blastic plasmacytoid dendritic cell neoplasm

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    Some Identities on the High-Order -Euler Numbers and Polynomials with Weight 0

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    We construct the th order nonlinear ordinary differential equation related to the generating function of -Euler numbers with weight 0. From this, we derive some identities on -Euler numbers and polynomials of higher order with weight 0

    Work Experience and Identity of Skilled Male Workers following the Economic Crisis

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    This article was originally published in 2001 in 『한국문화인류학』 [Korean cultural anthropology] 34(1): 139‒167; Translated into English by Ben Jackson.(In lieu of an abstract) The recent economic slump and structural adjustments have caused unprecedented mass unemployment and job instability. Unemployment is a crisis for the ideology of the male breadwinner in Korean society, sometimes seen as bringing rapid dissolution of or discord in families. The economic depression means long-term financial scarcity; its social effects manifest themselves strongly in the lives of blue-collar workers who live on tight budgets and are relatively lacking in supplementary resources. This article addresses the question of how male workers in the steel and iron industry are experiencing and interpreting changes in their workplaces under the current neoliberal economic order with its accelerating economic depression and demands for labor flexibility

    IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model

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    PURPOSE. While the association between the gut microbiome and the immune system has been studied in autoimmune disorders, little is known about ocular disease. Previously we reported that IRT5, a mixture of five probiotic strains, could suppress autoimmune dry eye. In this study, we investigated the mechanism by which IRT5 performs its immunomodulatory function in a mouse model of autoimmune dry eye. METHODS. NOD.B10.H2b mice were used as an autoimmune dry eye model. Either IRT5 or PBS was gavaged orally for 3 weeks, with or without 5 days of antibiotic pretreatment. The effects on clinical features, extraorbital lacrimal gland and spleen proteins, and fecal microbiota were analyzed. RESULTS. The ocular staining score was lower, and tear secretion was higher, in the IRT5-treated groups than in the PBS-treated groups. After IRT5 treatment, the downregulated lacrimal gland proteins were enriched in the biological processes of defense response and immune system process. The relative abundances of 33 operational taxonomic units were higher, and 53 were lower, in the feces of the IRT5-treated groups than in those of the PBS-treated groups. IRT5 administration without antibiotic pretreatment also showed immunomodulatory functions with increases in the Lactobacillus helveticus group and Lactobacillus hamsteri. Additional proteomic assays revealed a decrease of proteins related to antigen-presenting processes in the CD11b(+) and CD11c(+) cells of spleen in the IRT5-treated groups. CONCLUSIONS. Changes in the gut microbiome after IRT5 treatment improved clinical manifestations in the autoimmune dry eye model via the downregulation of antigen-presenting processes in immune networks.11Ysciescopu

    CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury

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    Neutrophil adhesion and migration are critical in hepatic ischemia/reperfusion (I/R) injury. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy in reperfusion injury. Therefore, the aim of this study was to assess the role of CD44 in neutrophil infiltration and liver injury from hepatic I/R. In this study, using a partial hepatic ischemic model in vivo, we determined the potential role of CD44 in neutrophil infiltration and liver injury from I/R. Reperfusion caused significant hepatocellular injury as it was determined by plasma ALT levels and liver histopathology. The injury was associated with a marked neutrophil recruitment and CD44 expression into the ischemic livers. Administration of anti-CD44 antibody to mice reduced the infiltration of neutrophil into the ischemic tissue, associated with liver function preservation. These results support crucial roles of CD44 in neutrophil recruitment and infiltration leading to liver damage in hepatic I/R injury. Moreover, they provide the rationale for targeting to CD44 as a potential therapeutic approach in liver I/R injury
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