Role of thermal friction in relaxation of turbulent Bose-Einstein condensates

In recent experiments, the relaxation dynamics of highly oblate, turbulent Bose-Einstein condensates (BECs) was investigated by measuring the vortex decay rates in various sample conditions [Phys. Rev. A $\bf 90$, 063627 (2014)] and, separately, the thermal friction coefficient $\alpha$ for vortex motion was measured from the long-time evolution of a corotating vortex pair in a BEC [Phys. Rev. A $\bf 92$, 051601(R) (2015)]. We present a comparative analysis of the experimental results, and find that the vortex decay rate $\Gamma$ is almost linearly proportional to $\alpha$. We perform numerical simulations of the time evolution of a turbulent BEC using a point-vortex model equipped with longitudinal friction and vortex-antivortex pair annihilation, and observe that the linear dependence of $\Gamma$ on $\alpha$ is quantitatively accounted for in the dissipative point-vortex model. The numerical simulations reveal that thermal friction in the experiment was too strong to allow for the emergence of a vortex-clustered state out of decaying turbulence.Comment: 7 pages, 5 figure

Changes in the Outdoor Wear Market: Focused on the South Korean Market

People have become interested in wellness and health, which has led to well-being trends and increased participation in activities. Therefore, the outdoor wear market has shown growth for several years. However, the outdoor wear market of South Korea is becoming saturated. Moreover, Outdoor wear consumers are tired of same design products. The sportswear companies are trying to develop athleisure products. Therefore, it is time to develop outdoor products for emotional approach. According to results, when consumers purchase outdoor wear, they consider the functionality of the materials more than they do when purchasing ordinary clothes. Outdoor wear consumers\u27 pursued images were classified into three types: urban, minimalist, and active. Outdoor wear selection criteria were classified into two types: instrumental function and expressive function. Outdoor wear brands need to qualify their products functionally and meet their segmented consumers\u27 demands by developing products depending on their image from the planning stage

Rheological method for alpha test evaluation of developing superplasticizers' performance: Channel flow test

Advance in high-range water-reducing admixture revolutionizes the workability and constructability of conventional vibrated concrete as well as self-consolidating concrete. Its need from construction fields has increased, and consequently a variety of new-type polycarboxylates, base polymers for the admixture, are being formulated in these days. Synthesizing new polymers needs a quick, but reliable, test to evaluate its performance on concrete. The test is also asked for selecting the best applicable brand of them before a test concrete will be mixed. This paper proposes a channel flow test and its usage for the purpose. The proposed procedure for the test includes the mix proportion of a test mortar, the test method, and rheological interpretation of the test results.ope

Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels

Gene expression is regulated at the transcriptional and post-transcriptional levels. Therefore, in order to achieve a high level of silencing, which includes minimizing any residual expression of a target gene, suppression at both the transcriptional and post-transcriptional levels is required. In this study, we describe a new method for highly efficient gene silencing that combines zinc finger protein-mediated transcriptional repression and small interfering RNA (siRNA)-mediated inhibition of post-transcriptional events. To measure the amount of gene expression under various conditions, we used a luciferase reporter gene that was driven by a variety of promoters, including that of the human vascular endothelial growth factor-A (VEGF-A) gene. We also measured expression of the endogenous VEGF-A gene. Inhibition of gene expression by each of the two individual technologies was effective, but in-depth analyses revealed residual expression of the target gene. The combination of specific zinc finger transcription factors and siRNAs greatly enhanced the silencing of the human VEGF-A gene, not only when cells were grown in the presence of normal amounts of oxygen but also under conditions of hypoxic stimulation. These results suggest that a bi-level approach to the silencing of VEGF-A expression may be clinically beneficial as part of a cancer treatment protocol

The promoter -1031(T/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary syndrome

<p>Abstract</p> <p>Background</p> <p>A <it>tumor necrosis factor-alpha </it>is a multifunctional pro-inflammation cytokine, which has been considered as one of pathogenic factors for various diseases. The promoter -1031(T/C) polymorphism in the <it>tumor necrosis factor-alpha </it>gene was reported that it plays a part in reproduction-related diseases. Among these, polycystic ovary syndrome (PCOS) is known to be a common gynecological disease of women in reproductive age women. Here, we performed a comparative study of -1031(T/C) polymorphism of <it>TNF-alpha </it>gene with PCOS in a Korean population.</p> <p>Methods</p> <p>The -1031(T/C) polymorphism of <it>TNF-alpha </it>gene was analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in a total of 217 PCOS patients and 144 matched female controls of healthy women. And statistical analysis was performed using HapAnalyzer. <it>X</it>²test and logistic regression were utilized analyze the association between two groups. A <it>p</it>-value under 0.05 was considered statistically significant.</p> <p>Results</p> <p>The genotype and allelic frequencies were in Hardy-Weinberg equilibrium (HWE). There was strong association between the -1031(T/C) polymorphism in the promoter region of <it>TNF-alpha </it>gene and PCOS (<it>p</it>-value = 0.0003, odd ratio (OR) = 2.53). In addition, the frequency of C allele was significantly higher in PCOS patients compared with controls. Sequence analyses also showed the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene.</p> <p>Conclusion</p> <p>This is the first study on the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene in PCOS. We concluded that the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene is associated with PCOS in a Korean population. Therefore, it is possible that it may be considered as a clinical biomarker to diagnose for PCOS, and is helpful in understanding the etiology for the pathogenesis of PCOS.</p

Meteorin regulates mesendoderm development by enhancing nodal expression

During gastrulation, distinct lineage specification into three germ layers, the mesoderm, endoderm and ectoderm, occurs through an elaborate harmony between signaling molecules along the embryonic proximo-distal and anterior-posterior axes, and Nodal signaling plays a key role in the early embryonic development governing embryonic axis formation, mesoderm and endoderm specification, and left-right asymmetry determination. However, the mechanism by which Nodal expression is regulated is largely unknown. Here, we show that Meteorin regulates Nodal expression and is required for mesendoderm development. It is highly expressed in the inner cell mass of blastocysts and further in the epiblast and extra-embryonic ectoderm during gastrulation. Genetic ablation of the Meteorin gene resulted in early embryonic lethality, presumably due to impaired lineage allocation and subsequent cell accumulation. Embryoid body culture using Meteorin-null embryonic stem (ES) cells showed reduced Nodal expression and concomitant impairment of mesendoderm specification. Meteorin-null embryos displayed reduced levels of Nodal transcripts before the gastrulation stage, and impaired expression of Goosecoid, a definitive endoderm marker, during gastrulation, while the proximo-distal and anterior-posterior axes and primitive streak formation were preserved. Our results show that Meteorin is a novel regulator of Nodal transcription and is required to maintain sufficient Nodal levels for endoderm formation, thereby providing new insights in the regulation of mesendoderm allocation.open1113sciescopu

AD-YOLO: You Look ONly Once in Training Multiple Sound Event Localization and Detection

Sound event localization and detection (SELD) combines the identification of sound events with the corresponding directions of arrival (DOA). Recently, event-oriented track output formats have been adopted to solve this problem; however, they still have limited generalization toward real-world problems in an unknown polyphony environment. To address the issue, we proposed an angular-distance-based multiple SELD (AD-YOLO), which is an adaptation of the "You Look Only Once" algorithm for SELD. The AD-YOLO format allows the model to learn sound occurrences location-sensitively by assigning class responsibility to DOA predictions. Hence, the format enables the model to handle the polyphony problem, regardless of the number of sound overlaps. We evaluated AD-YOLO on DCASE 2020-2022 challenge Task 3 datasets using four SELD objective metrics. The experimental results show that AD-YOLO achieved outstanding performance overall and also accomplished robustness in class-homogeneous polyphony environments.Comment: 5 pages, 3 figures, accepted for publication in IEEE ICASSP 202

An Active and Soft Hydrogel Actuator to Stimulate Live Cell Clusters by Self-folding

The hydrogels are widely used in various applications, and their successful uses depend on controlling the mechanical properties. In this study, we present an advanced strategy to develop hydrogel actuator designed to stimulate live cell clusters by self-folding. The hydrogel actuator consisting of two layers with different expansion ratios were fabricated to have various curvatures in self-folding. The expansion ratio of the hydrogel tuned with the molecular weight and concentration of gel-forming polymers, and temperature-sensitive molecules in a controlled manner. As a result, the hydrogel actuator could stimulate live cell clusters by compression and tension repeatedly, in response to temperature. The cell clusters were compressed in the 0.7-fold decreases of the radius of curvature with 1.0 mm in room temperature, as compared to that of 1.4 mm in 37 degrees C. Interestingly, the vascular endothelial growth factor (VEGF) and insulin-like growth factor-binding protein-2 (IGFBP-2) in MCF-7 tumor cells exposed by mechanical stimulation was expressed more than in those without stimulation. Overall, this new strategy to prepare the active and soft hydrogel actuator would be actively used in tissue engineering, drug delivery, and micro-scale actuators

Quality of life in intermittent exotropia for Korean children and their parents

Background Patients with strabismus are more likely to have mental health problems, including high rates of depressive symptoms and social phobia. Intermittent exotropia (IXT) typically occurs in early childhood and is more common in Asian populations. We aim to assess the health-related quality of life (HRQOL) concerns in children with intermittent exotropia (IXT) using the Intermittent Exotropia Questionaire (IXTQ), and their associations with the clinical severity of IXT and the parents HRQOL concerns. Methods IXT, defined as both distance and near exodeviation ≥ 10 prism diopters were eligible for inclusion. The final IXTQ score is calculated using the mean score for all items, and ranges from 0 (worst HRQOL) to 100 (best HRQOL). The correlations of child IXTQ scores with their deviation angle and stereoacuity were measured, as were those with their parents IXTQ scores. Results One hundred twenty-two children with IXT (aged 5–17 years) and one parent for each child completed the child and parent IXTQ, respectively. The greatest HRQOL concern for each child with IXT and their parent was Worry about eyes (frequency 88%, score 35.0 ± 27.8). Lower child IXTQ scores were associated with a larger distance (r = 0.24, p = 0.007) and near deviation angle (r = 0.2, p = 0.026). It bothers me because I have to wait for my eyes to clear up and Waiting for their eyes to clear up were more common in children with a larger deviation angle (both p < 0.05). The parent IXTQ scores (52.1 ± 25.3) were lower than the child ones (79.7 ± 15.8) and showed a positive correlation with child IXTQ scores (r = 0.26, p = 0.004). Lower parent IXTQ scores were associated with poor distance stereoacuity (r = 0.23, p = 0.01). Conclusion The HRQOL of IXT children was positively related to that of their parents. A larger deviation angle and worse distance stereoacuity function may predict more-negative impacts on children and their parents, respectively.This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (No. 2020R1C1C1010834)