Expanding Universe and Dynamical Compactification Using Yang-Mills Instantons

We consider an eight-dimensional Einstein-Yang-Mills theory to explore whether Yang-Mills instantons formed in extra dimensions can induce the dynamical instability of our four-dimensional spacetime. We show that the Yang-Mills instantons in extra dimensions can trigger the expansion of our universe in four-dimensional spacetime as well as the dynamical compactification of extra dimensions. We also discuss a possibility to realize a reheating mechanism via the quantum back-reaction from the contracting tiny internal space with a smeared instanton.Comment: v3; 26 pages, 6 figures, version to be published in JHE

Einstein Structure of Squashed Four-Spheres

It is known that the moduli space of Einstein structures is an isolated point so that an Einstein structure has no infinitesimal Einstein deformations. We examine the rigidity of the Einstein structure by considering deformations of the round four-sphere $\mathbb{S}^4$. We show that any deformation of the round four-sphere $\mathbb{S}^4$ causes it to deviate from the Einstein structure, except trivial deformations at most only changing the size of the sphere.Comment: v2: 22 pages, 1 figure, references adde

The Detection Data Processing Mechanism for Vehicular Cyber Physical System in IoT Environment

With the development of the Internet of Things and big data technology, it was easy to collect personal situation information. The information collected in this way requires the user to support customized services via big data technology. However, traditional situational awareness systems request action through user cognition or provide consistent services for the specific purposes of multiple users. Therefore, this paper proposes a mechanism of Vehicular CPS with situational cognitive function that minimizes direct user intervention for user customization services. In this paper, we designed the system configuration and detailed process based on the scenario of the situation where the user is driving a car. A vector is used to provide a method for determining a dangerous water level by analyzing an abnormal state of a reception threshold with a sensor. The proposed system was analyzed by simulation. By using the authorization step that operates based on the sensor data, we were able to know that the reliability of the user is improved and that the reliable processing of the IoT service is possible. In the future, research for personal authentication and encryption is needed for more secure information processing

Generalization of Instanton-Induced Inflation and Dynamical Compactification

It was shown that Yang-Mills instantons on an internal space can trigger the expansion of our four-dimensional universe as well as the dynamical compactification of the internal space. We generalize the instanton-induced inflation and dynamical compactification to general Einstein manifolds with positive curvature and also to the FLRW metric with spatial curvature. We explicitly construct Yang-Mills instantons on all Einstein manifolds under consideration and find that the homogeneous and isotropic universe is allowed only if the internal space is homogeneous. We then consider the FLRW metric with spatial curvature as a solution of the eight-dimensional Einstein-Yang-Mills theory. We find that open universe $(k=-1)$ admits bouncing solutions unlike the other cases $(k=0, +1)$.Comment: 30 pages, 5 figure

Quantitative Screening of Cervical Cancers for Low-Resource Settings: Pilot Study of Smartphone-Based Endoscopic Visual Inspection After Acetic Acid Using Machine Learning Techniques

Background: Approximately 90% of global cervical cancer (CC) is mostly found in low- and middle-income countries. In most cases, CC can be detected early through routine screening programs, including a cytology-based test. However, it is logistically difficult to offer this program in low-resource settings due to limited resources and infrastructure, and few trained experts. A visual inspection following the application of acetic acid (VIA) has been widely promoted and is routinely recommended as a viable form of CC screening in resource-constrained countries. Digital images of the cervix have been acquired during VIA procedure with better quality assurance and visualization, leading to higher diagnostic accuracy and reduction of the variability of detection rate. However, a colposcope is bulky, expensive, electricity-dependent, and needs routine maintenance, and to confirm the grade of abnormality through its images, a specialist must be present. Recently, smartphone-based imaging systems have made a significant impact on the practice of medicine by offering a cost-effective, rapid, and noninvasive method of evaluation. Furthermore, computer-aided analyses, including image processing-based methods and machine learning techniques, have also shown great potential for a high impact on medicinal evaluations

‘Evidence of an auxin signal pathway, microRNA167-ARF8-GH3, and its response to exogenous auxin in cultured rice cells’

MicroRNA167 (miR167) was shown to cleave auxin responsive factor 8 (ARF8) mRNA in cultured rice cells. MiR167 level was found to be controlled by the presence of auxin in the growth medium. When cells grew in auxin-free medium, miR167 level decreased, resulting in an increase in the level of ARF8 mRNA. Cells growing in the normal growth medium containing auxin showed a reversed trend. It was also shown that expression of OsGH3-2, an rice IAA-conjugating enzyme, was positively regulated by ARF8. Delivery of synthesized miR167 into cells led to decrease of both ARF8 mRNA and OsGH3-2 mRNA. This study provides an evidence in which the exogeneous auxin signal is transduced to OsGH3-2 through miR167 and ARF8 in sequence. This proposed auxin signal transduction pathway, auxin-miR167-ARF8-OsGH3-2, could be, in conjunction with the other microRNA-mediated auxin signals, an important one for responding to exogeneous auxin and for determining the cellular free auxin level which guides appropriate auxin responses

Phytohormone abscisic acid control RNA-dependent RNA polymerase 6 gene expression and post-transcriptional gene silencing in rice cells

RNA-dependent RNA polymerase 6 (RDR6) catalyses dsRNA synthesis for post-transcriptional gene silencing (PTGS)-associated amplification and the generation of endogeneous siRNAs involved in developmental determinations or stress responses. The functional importance of RDR6 in PTGS led us to examine its connection to the cellular regulatory network by analyzing the hormonal responses of RDR6 gene expression in a cultured cell system. Delivery of dsRNA, prepared in vitro, into cultured rice (Oryza sativa cv. Japonica Dongjin) cells successfully silenced the target isocitrate lyase (ICL) transcripts. Silencing was transient in the absence of abscisic acid (ABA), while it became persistent in the presence of ABA in growth medium. A transcription assay of the OsRDR6 promoter showed that it was positively regulated by ABA. OsRDR6-dependent siRNA(ICL) generation was also significantly up-regulated by ABA. The results showed that, among the five rice OsRDR isogenes, only OsRDR6 was responsible for the observed ABA-mediated amplification and silencing of ICL transcripts. We propose that ABA modulates PTGS through the transcriptional control of the OsRDR6 gene