Additional file 1: Table S1. of Comparison of the association of mammographic density and clinical factors with ductal carcinoma in situ versus invasive ductal breast cancer in Korean women

Influence of the method of subjects recruitment on the association of the clinical, reproductive, and mammographic density characteristics with invasive ductal carcinoma and ductal carcinoma in situ. Table S2 Association of body mass index with breast cancer according to menopausal status. (DOCX 23 kb

Correlations between axial length (AL) and peripapillary atrophy (PPA)-to-disc ratio and angular location of retinal vein.

<p>(A), (B) Positively linear correlations were shown between AL and PPA-to-disc ratio. (C-F) Negatively linear correlations were shown between AL and angular locations of retinal vessels, but the correlations seemed weak.</p

Correlations of fundus parameters between family members.

<p>Correlations of fundus parameters between family members.</p

Intraobserver and interobserver reliability in fundus parameters.

<p>Intraobserver and interobserver reliability in fundus parameters.</p

Characteristics of study subjects and their eyes.

<p>Characteristics of study subjects and their eyes.</p

Representative cases.

<p>(A, B) Monozygote (MZ) twins with axial length (AL) > 24 mm. (C, D) MZ twins with AL < 24 mm. The areas and the locations of PPA are similar between MZ twins. Though the PPA area was shown to be correlated with AL, there were some exceptions that are thought to be associated with familial inheritance. MZ twin eyes with shorter AL (D) show greater PPA areas compared to the other MZ twin eyes with longer AL (A). The angular locations of retinal veins show various values even between MZ twins.</p

Classification of the location of β-zone PPA.

<p>(A) When the location of β-zone PPA was greater than 15 degrees superior, it was classified as superior. (B) When the location of β-zone PPA was less than 15 degrees, it was classified as temporal. (C) When the location of β-zone PPA was greater than 15 degrees inferior, it was classified as inferior. (D) When the β-zone PPA was located circumferentially, it was regarded as circumferential.</p

Parameter measurements in the present study.

<p>(A) Fovea-to-disc center distance connected the foveal center and optic disc center and was defined as the reference value (white line). The β-zone PPA was defined as the region of chorioretinal atrophy containing both visible sclera and choroidal vessels adjacent to the optic disc (dotted white line). Disc area was defined as the region in the inner margin of scleral ring around optic disc. PPA-to-disc area ratio was used as the modified PPA area in order to compensate for the magnification effect due to AL. The location of β-zone PPA was defined as the angle of the point of maximal radial extent from the reference line (yellow line). The point of maximum radial extent was the point on the temporal β-zone PPA margin where the radial extent of the β-zone PPA was maximal (yellow arrow). (B) The vein angular location was defined as the angle between the fovea-to-disc center (reference) and the largest temporal vein. To define the location of the vein, a circle with a radius half the distance of the fovea-to-disc center was drawn (dotted white line). The point at which the circle meets the vein was regarded as the location of vein (each end of the superior and inferior white lines). The angle between the location of superior vein and the reference was defined as the angular location of the superior vein (angle α). The angle between the location of the inferior vein and the reference was defined as the angular location of the inferior vein (angle β). The ratio of the superior vein angle and the inferior vein angle was defined as the vein angular location ratio.</p

Heritability (<i>h</i>^<i>2</i>) of the fundus parameter measurements.

<p>Heritability (<i>h</i>^<i>2</i>) of the fundus parameter measurements.</p