Relationship Between Histological Features of Non-alcoholic Fatty Liver Disease and Ectopic Fat on Magnetic Resonance Imaging in Children and Adolescents

Objectives: To investigate the association between ectopic fat content in the liver and pancreas, obesity-related metabolic components, and histological findings of non-alcoholic fatty liver disease (NAFLD) in children.Methods: This cross-sectional study investigated 63 children with biopsy-proven NAFLD who underwent magnetic resonance imaging (MRI), anthropometry, laboratory tests, and body composition analysis. Clinical and metabolic parameters, MRI-measured hepatic fat fraction (HFF) and pancreatic fat fraction (PFF), and histological findings were analyzed.Results: In a total of 63 children (48 boys, median age 12.6 years, median body mass index z-score 2.54), HFF was associated with histological steatosis [10.4, 23.7, and 31.1% in each steatosis grade, P < 0.001; Spearman's rho coefficient (rs) = 0.676; P < 0.001] and NAFLD activity score (rs = 0.470, P < 0.001), but not with lobular inflammation, hepatocyte ballooning, and hepatic fibrosis. PFF was not associated with any histological features of the liver. Waist circumference-to-height ratio and body fat percentage were associated with the steatosis grade (P = 0.006 and P = 0.004, respectively). Alanine aminotransferase was not associated with steatosis but was associated with lobular inflammation (P = 0.008). Lobular inflammation was also associated with high total cholesterol and low-density lipoprotein cholesterol and metabolic syndrome (P = 0.015, P = 0.036, and P = 0.038, respectively).Conclusions: Hepatic steatosis on MRI was only associated with the histological steatosis grade, while elevated serum levels of liver enzymes and lipids were related to the severity of lobular inflammation. Therefore, MRI should be interpreted in conjunction with the anthropometric and laboratory findings in pediatric patients

Color Dispersion as an Indicator of Stellar Population Complexity: Insights from the Pixel Color-Magnitude Diagrams of 32 Bright Galaxies in Abell 1139 and Abell 2589

We investigate the properties of bright galaxies of various morphological types in Abell 1139 and Abell 2589, using pixel color-magnitude diagram (pCMD) analysis. The sample contains 32 galaxies brighter than M-r = -21.3 mag with spectroscopic redshifts, which are deeply imaged in the g and r bands using the MegaCam mounted on the Canada-France-Hawaii Telescope. After masking contaminants with two-step procedures, we examine how the detailed properties in the pCMDs depend on galaxy morphology and infrared color. The mean g - r color as a function of surface brightness (mu(r)) in the pCMD of a galaxy shows good performance in distinguishing between early- and late-type galaxies, but it is not perfect because of the similarity between elliptical galaxies and bulge-dominated spiral galaxies. On the other hand, the g - r color dispersion as a function of mu(r) works better. We find that the best set of parameters for galaxy classification is a combination of the minimum color dispersion at mu(r) <= 21.2 mag arcsec(-2) and the maximum color dispersion at 20.0 <= mu(r) <= 21.0 mag arcsec(-2); the latter reflects the complexity of stellar populations at the disk component in a typical spiral galaxy. Finally, the color dispersion measurements of an elliptical galaxy appear to be correlated with the Wide-field Infrared Survey Explorer infrared color ([4.6]-[12]). This indicates that the complexity of stellar populations in an elliptical galaxy is related to its recent star formation activities. From this observational evidence, we infer that gas-rich minor mergers or gas interactions may have usually occurred during the recent growth of massive elliptical galaxies