Evaluation of Carcinogenic Risks to Humans,

This publication represents the views and expert opinions of an IARC Working Group on th

5 Chapter 2 Contribution of First- versus Second-Generation Products to Secondary Organic Aerosols Formed in the Oxidation of

This chapter is reproduced by permission from “Contribution of first- versus second-generation products to secondary organic aerosols formed in the oxidation of biogenic hydrocarbons ” by N. L. Ng, J. H. Kroll

Perspectives Correspondence Comment on “Sexual Maturation in Relation to Polychlorinated Aromatic

interesting, mainly because the reported work demonstrates the potential of biomarkers in environmental health programs. However, we argue with the authors ’ conclusion that their findings suggest that, in line with the concept of endocrine disruption and Sharpe and Skakkebaek’s hypothesis [Sharpe and Skakkebaek 1993], environmental exposure to PCAHs [polychlorinated aromatic hydrocarbons] may adversely interfere with the sexual maturation during the fetal and pubertal stages of development. The description of the project suggests that the study was designed to investigate the effects of incinerator emissions on the loca

UPDATE STATEMENT

The use of company or product name(s) is for identification only and does not imply endorsement b

Hazard Characterization Document SCREENING-LEVEL HAZARD CHARACTERIZATION

Hydrocarbons, terpene processing by-products (CASRN 68956-56-9

SPONSORED CHEMICALS

The High Production Volume (HPV) Challenge Program 1 was conceived as a voluntary initiative aimed at developing and making publicly available screening-level health and environmental effects information on chemicals manufactured in or imported into the United States in quantities greater than one million pounds per year. In the Challenge Program, producers and importers of HPV chemicals voluntarily sponsored chemicals; sponsorship entailed the identification and initial assessment of the adequacy of existing toxicity data/information, conducting new testing if adequate data did not exist, and making both new and existing data and information available to the public. Each complete data submission contains data on 18 internationally agreed to “SIDS” (Screening Information Data Set 1,2) endpoints that are screening-level indicators of potential hazards (toxicity) for humans or the environment. The Environmental Protection Agency’s Office of Pollution Prevention and Toxics (OPPT) is evaluating the data submitted in the HPV Challenge Program on approximately 1400 sponsored chemicals by developing hazard characterizations (HCs). These HCs consist of an evaluation of the quality and completeness of the data set provided in the Challenge Program submissions. They are not intended to be definitive statements regarding the possibility of unreasonable risk o

Sorne Arornatic Amines, Hydrazine and Related Substances, N-Nitroso Cornpounds and Miscellaneous Alkylating Agents

(7 rnonographs), 181 page

C- National: Federal Regulations

choic

Humans

See the monograph on Household use of solid fuels. Siegmann and Sattler (1996) detected a variety of genotoxic PAHs (e.g. benzo[a]anthracene, chrysene, benzo[a]pyrene) in vegetable oils (rapeseed, corn and peanut) heated to above 260ºC (1.1–22.8 µg/m 3 PAHs). Wu et al. (1998) detected a variety of mutagenic PAHs (e.g. benzo[a]pyrene) and nitro-PAHs (e.g. 1,3-dinitropyrene) in fumes of lard, soya bean oil and peanut oil heated to above 250ºC; the emission of PAHs and nitro-PAHs were reduced upon addition of the antioxidant catechin

in the Former USSR

The content of major carcinogenic and genotoxic polyaromatic hydrocarbons (PAH) in urban air, vehicle, and industrial emissions is assessed. A sensitive, specific, and selective method for PAH and nitro-PAH quantitation was developed on the basis of low-temperature luminescence-spectra of frozen polycrystalline solutions. Polyarene contents in urban air and urban industrial emissions, as well as vehicle exhausts, are compared to the Russian Ministry of Health standard of maximal permissible concentration for benzo[alpyrene in the ambient air. Special attention was paid to the study of PAH profiles and characteristics of different sources. The feasibility of using benzo[alpyrene to assess PAH content in industrial and vehicle emissions was explored. PAH profiles in the ambient air and local emissions are compared. In addition, genotoxicity of the emissions of coke plant and diesel engine exhausts are compared to their polyarene content. Environ Health Perspect 102(Suppl 4):49-53 (1994). carcinogenic and genotoxic polyaromatic hydrocarbons (PAH), industrial emissions, luminescence spectra, maximal permissible concen-Key words: tration (MPC), nitro-PAH, urban air pollution, vehicle exhaust