373 research outputs found

    Low Less Etchless Silicon Waveguides

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    Fabrication of silicon waveguides without performing any silicon etching is demonstrated. The silicon waveguides are defined by the concept of “selective oxidation”. The experiment demonstrates that the waveguides formed by selective oxidation produce ultra-smooth sidewalls since etching of silicon is avoided. The Si etching usually creates damage from ion bombardment and chemical reactions that occur during plasma etching. The final waveguide also demonstrates very low light low based on optical testing which shows that no light scattering is observed. The final waveguide has a width of 1.5 ÎŒm and a height of ~80 nm. The GCA stepper is utilized to expose the SOl sample. In order to do this an alternative method of exposing a wafer piece is needed which excludes the use of a special wafer pedal. This method is also demonstrated in the paper

    The Effect of Public Officers Work-Life Balance on Job Satisfaction Differences between Men and Women

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    We performed an empirical analysis based on data from a questionnaire survey that Korean government officers participated in about the effects of worklife balance (WLB) on job satisfaction in order to whether unpaid labor such as housework had a moderating effect on job satisfaction. The subjective balance of an individuals time input in work and life was used to measure WLB. We find that WLB has a positive and significant effect on job satisfaction and that there is no statistically significant gender difference. However, the WLB effect on married female officers is smaller than that on single female officers, while it is not significant for male public officers. Child-rearing has a negative moderating effect on womens job satisfaction, although this was not statistically significant. This result suggests that the effect of the household work burden that marriage as well as child care brings is a variable that policy makers should be keep in mind in developing WLB policies

    Production of transgenic rice (indica cv. MR219) overexpressing Abp57 Gene through Agrobacterium-mediated transformation

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    Agrobacterium-mediated transformation of indica rice is undoubtedly a challenging task due to the rice recalcitrant nature to transformation process. Therefore, optimization of the transformation protocol is important for specific indica rice cultivar to ensure effectiveness of the transformation. In this study, crucial parameters affecting Agrobacterium-mediated transformation were optimized to obtain transgenic rice of local rice cultivar (indica MR219). Embryogenic calli were chosen for inoculation with Agrobacterium tumefaciens strain LBA4404 harbouring a binary vector pH2GW7-ABP57 containing gene of interest, Auxin binding protein 57 (Abp57). The parameters that have been optimized were the immersion time, co-cultivation period, acetosyringone concentration and co-cultivation temperature. A total of four days co-cultivation period and 30 min immersion of embryogenic callus are optimum for the transformation of MR219 with transformation efficiency of 26.4% and 16.0%, respectively. Acetosyringone at 200 ΌM and co-cultivation at 28°C also gave the highest transformation efficiency (14.4 and 18.4%, respectively). Meanwhile, inclusion of 20 g/L maltose+20 g/L sorbitol into the regeneration media has significantly improve the transformed somatic embryos growth and increase the regeneration efficiency up to 40.0%. The results of polymerase chain reaction (PCR) and reverse transcription-polymerase chain reaction (RT-PCR) indicated that the transgene was successfully integrated and overexpressed in transgenic rice of MR219. In conclusion, significant improvement in transformation efficiency for rice cv. MR219 has been obtained by using the optimised protocol for transformation and regeneration developed in this study

    LOCATION DESIGN FOR EMERGENCY MEDICAL CENTERS BASED ON CATEGORY OF TREATABLE MEDICAL DISEASES AND CENTER CAPABILITY

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    Abstract: Through the development of a mathematical model, this paper studies the location design of emergency medical centers in a given region under the closest assignment rule. It is assumed that the capability and capacity to treat various categories of treatable medical diseases are provided for each candidate medical center. Once a candidate center is selected, it will receive subsidies from the government to support the offering of medical services at a competitive cost. It is further assumed that the number of patients occurring at each patient group node during a unit time is known along with the categories of their diseases. With the objective of minimizing the total subsidies paid, we select from among the candidate emergency medical centers subject to a maximum total budget and minimum desired survival rate constraints. The CPLEX version 12.1 solver is used to obtain an optimal solution. Simulation studies are conducted to assess the performance of our deterministic models in a stochastic context

    Prediction of Alzheimer's disease pathophysiology based on cortical thickness patterns

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    AbstractIntroductionRecent studies have shown that pathologically defined subtypes of Alzheimer's disease (AD) represent distinctive atrophy patterns and clinical characteristics. We investigated whether a cortical thickness–based clustering method can reflect such findings.MethodsA total of 77 AD subjects from the Alzheimer's Disease Neuroimaging Initiative 2 data set who underwent 3-T magnetic resonance imaging, [18F]-fluorodeoxyglucose-positron emission tomography (PET), [18F]-Florbetapir PET, and cerebrospinal fluid (CSF) tests were enrolled. After clustering based on cortical thickness, diverse imaging and biofluid biomarkers were compared between these groups.ResultsThree cortical thinning patterns were noted: medial temporal (MT; 19.5%), diffuse (55.8%), and parietal dominant (P; 24.7%) atrophy subtypes. The P subtype was the youngest and represented more glucose hypometabolism in the parietal and occipital cortices and marked amyloid-beta accumulation in most brain regions. The MT subtype revealed more glucose hypometabolism in the left hippocampus and bilateral frontal cortices and less performance in memory tests. CSF test results did not differ between the groups.DiscussionCortical thickness patterns can reflect pathophysiological and clinical changes in AD

    Effects of Textural Properties on the Response of a SnO2-Based Gas Sensor for the Detection of Chemical Warfare Agents

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    The sensing behavior of SnO2-based thick film gas sensors in a flow system in the presence of a very low concentration (ppb level) of chemical agent simulants such as acetonitrile, dipropylene glycol methyl ether (DPGME), dimethyl methylphosphonate (DMMP), and dichloromethane (DCM) was investigated. Commercial SnO2 [SnO2(C)] and nano-SnO2 prepared by the precipitation method [SnO2(P)] were used to prepare the SnO2 sensor in this study. In the case of DCM and acetonitrile, the SnO2(P) sensor showed higher sensor response as compared with the SnO2(C) sensors. In the case of DMMP and DPGME, however, the SnO2(C) sensor showed higher responses than those of the SnO2(P) sensors. In particular, the response of the SnO2(P) sensor increased as the calcination temperature increased from 400 °C to 800 °C. These results can be explained by the fact that the response of the SnO2-based gas sensor depends on the textural properties of tin oxide and the molecular size of the chemical agent simulant in the detection of the simulant gases (0.1–0.5 ppm)
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