Online Reinforcement Learning of X-Haul Content Delivery Mode in Fog Radio Access Networks

We consider a Fog Radio Access Network (F-RAN) with a Base Band Unit (BBU) in the cloud and multiple cache-enabled enhanced Remote Radio Heads (eRRHs). The system aims at delivering contents on demand with minimal average latency from a time-varying library of popular contents. Information about uncached requested files can be transferred from the cloud to the eRRHs by following either backhaul or fronthaul modes. The backhaul mode transfers fractions of the requested files, while the fronthaul mode transmits quantized baseband samples as in Cloud-RAN (C-RAN). The backhaul mode allows the caches of the eRRHs to be updated, which may lower future delivery latencies. In contrast, the fronthaul mode enables cooperative C-RAN transmissions that may reduce the current delivery latency. Taking into account the trade-off between current and future delivery performance, this paper proposes an adaptive selection method between the two delivery modes to minimize the long-term delivery latency. Assuming an unknown and time-varying popularity model, the method is based on model-free Reinforcement Learning (RL). Numerical results confirm the effectiveness of the proposed RL scheme.Comment: 5 pages, 2 figure

Subinhibitory concentrations of trimethoprim and sulfamethoxazole prevent biofilm formation by Acinetobacter baumannii through inhibition of Csu pilus expression

ABSTRACT Acinetobacter baumannii is emerging as a multidrug-resistant nosocomial pathogen of increasing threat to human health worldwide. Pili are important bacterial virulence factors, playing a role in attachment to host cells and biofilm formation. The Csu pilus, which is assembled via the chaperone-usher secretion system, has been studied in A. baumannii ATCC 19606. Here we show that, in opposition to previous reports, the common laboratory strain ATCC 17978 produces Csu pili. We found that, although ATCC 17978 was resistant to sulfamethoxazole (Smx) and trimethoprim (Tmp), subinhibitory concentrations of these antibiotics abolished the expression of Csu and consequently produced a dramatic reduction in biofilm formation by ATCC 17978. Smx and Tmp acted synergistically to inhibit the enzymatic systems involved in the bacterial synthesis of tetrahydrofolate (THF), which is required for the synthesis of nucleotides. The effects of these antibiotics were partially relieved by exogenous THF addition, indicating that Smx and Tmp turn off Csu assembly by inducing folate stress. We propose that, for Acinetobacter , nanomolar concentrations of Smx and Tmp represent a “danger signal.” In response to this signal, Csu expression is repressed, allowing biofilm dispersal and escape from potentially inhibitory concentrations of antibiotics. The roles of antibiotics as signaling molecules are being increasingly acknowledged, with clear implications for both the treatment of bacterial diseases and the understanding of complex microbial interactions in the environment. </jats:p

Current-Induced Resonant Motion of a Magnetic Vortex Core: Effect of Nonadiabatic Spin Torque

The current-induced resonant excitation of a magnetic vortex core is investigated by means of analytical and micromagnetic calculations. We find that the radius and the phase shift of the resonant motion are not correctly described by the analytical equations because of the dynamic distortion of a vortex core. In contrast, the initial tilting angle of a vortex core is free from the distortion and determined by the nonadiabaticity of the spin torque. It is insensitive to experimentally uncontrollable current-induced in-plane Oersted field. We propose that a time-resolved imaging of the very initial trajectory of a core is essential to experimentally estimate the nonadiabaticity.Comment: 4 pages, 4 figure

Titanium oxide Films Prepared by Sputtering, Sol Gel and Dip Coating Methods for Photovoltaic Application

AbstractDye-sensitized solar cells (DSCs) without using transparent conducting oxides (TCO) electrode can be produced at much lower cost with a flexible structure. A new type of DSCs using flexible stainless steel mesh sheets based electrode is reported in this research. The working electrode of DSCs is processed with conductive and flexible stainless mesh coated with metal oxides (TiO2) layer either by sputtering, sol gel or dip coating methods. Structures of the TCO-less DSCs sample is a stainless mesh for working electrode/dye sensitized TiO2 layer/liquid type electrolyte with polymer film/Pt doped Ti plate for counter electrode. The metal oxide coated stainless mesh sample showed higher photo-current conversion efficiency in general. The best cell performance in this experiment showed the efficiency of 3.11% (Voc = 0.58V, Jsc = 11.98mA/cm2, ff = 0.45)

Age-related changes in cervical sagittal range of motion and alignment

Study Design Retrospective cohort study. Objective To compare sagittal cervical range of motion (ROM) and alignment in young versus middle-aged adults. Methods One hundred four asymptomatic adults were selected randomly out of 791 subjects who underwent lateral cervical radiographs in neutral, flexion, and extension positions. They were divided into two groups: young (age 20 to 29, 52 people) and middle-aged adults (age 50 to 59, 52 people). We determined the ROMs of upper cervical (occipital–C2 angle), midcervical (C2–C7 angle), and cervicothoracic spine (cervicosternal angle). We compared the alignment differences of the two groups by calculating the distances between C2 and C7 plumb lines, and C2 central-offset distance. Results In neutral position, there was no significant difference between young and middle-aged adults. However, in flexion, C2–C7 angle, distance between C2–C7 plumb lines, and C2 central-offset distance decreased with age. In extension, C2–C7 angle and C2 central-offset distance decreased with age. During flexion and extension, midcervical ROM and the range of C2 central-offset distance decreased in the middle-aged group. However, there was no difference between the two age groups in the ROM of the upper cervical and the cervicothoracic regions during flexion and extension. Conclusion We found that, despite of the presence of age-related cervical alignment changes, the only difference between the two groups was in the sagittal ROM of the midcervical spine during flexion and extension. Only the ROM of the midcervical spine appears to change significantly, consistent with findings that these levels are most likely to develop both symptomatic and asymptomatic degenerative changes

Mutant p53 succumbs to starvation

While the wild type form of p53 possesses strong tumor-suppressive activities, the p53 proteins that are commonly mutated in cancer often endow more malignant properties to the cancers they inhabit. There are several lines of evidence supporting such oncogenic gain of function of mutant p53. Compared with p53-null mice, knock-in mice harboring mutant p53 proteins display different and more metastatic tumor spectra. Such mutant proteins are frequently present at far higher levels than the wild-type protein in tumors; in fact, the p53 protein present in the knock-in mice accumulates in tumors despite being inherently unstable in normal tissues,3 suggesting that stabilization of mutant p53 protein is required for its oncogenic activity. Consistently, knockdown of mutant p53 protein in human cancer cell lines leads to reduced cell proliferation, invasion, motility, tumorigenicity and resistance to anticancer drugs. Since epidemiological studies indicate that high levels of mutant p53 proteins correlate with tumor aggressiveness and poorer outcomes, it is important to understand how mutant p53 is stabilized in tumors and how it can be eliminated. This article proposes questions brought up by earlier studies on mutant p53 proteins

Delayed surgical intervention in central cord syndrome with cervical stenosis

Study Design Review of the literature. Objective It is generally accepted that surgical treatment is necessary for central cord syndrome (CCS) with an underlying cervical stenosis. However, the surgical timing for decompression is controversial in spondylotic cervical CCS. The purpose of this study is to review the results of early and delayed surgery in patients with spondylotic cervical CCS. Methods MEDLINE was searched for English-language articles on CCS. There were 1,653 articles from 1940 to 2012 regarding CCS, 5 of which dealt with the timing of surgery for spondylotic cervical CCS. Results All five reports regarding the surgical timing of spondylotic cervical CCS were retrospective. Motor improvement, functional independence measures, and walking ability showed similar improvement in early and late surgery groups in the studies with follow-up longer than 1 year. However, greater improvement was seen in the early surgery group in the studies with follow-up shorter than 1 year. The complication rates did not show a difference between the early and late surgery groups. However, there are controversies regarding the length of intensive care unit stay or hospital stay for the two groups. Conclusions There was no difference in motor improvement, functional independence, walking ability, and complication rates between early and late surgery for spondylotic cervical CCS