6 research outputs found

    Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

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    To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

    The cost implications of refurbishment and demolish and built pathways for a dwelling energy upgrade

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    This paper attempts to compare the two pathways to reducing carbon in existing domestic stock with a focus on the cost implication through a case study of a 1980’s dwelling. The results show costs can vary significantly from project to project depending on the condition of the house, fabric, project scale, type of house, location etc. Moreover, the costs of rebuilding may be analogous to those of refurbishment and the performance greatly improved in some cases. However, a detailed assessment of the costs for either pathway for specific projects is recommended. On average a low energy new build is approximately 20% more expensive than a low energy retrofit. It can also be concluded that although large scale refurbishments are necessary for achieving the 2050 target, demolition and rebuilding of select buildings (depending on the condition and socio-economic context) can be carried out without the costs being prohibitive
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