46 research outputs found
Preliminary performance measurements of bolometers for the Planck high-frequency instrument
We report on the characterization of bolometers fabricated at the Jet Propulsion Laboratory for the High Frequency Instrument (HFI) of the joint ESA/NASA Herschel/Planck mission to be launched in 2007. The HFI is a multicolor focal plane which consists of 48 bolometers operated at 100mK. Each bolometer is mounted to a feedhorn-filter assembly which defines one of six frequency bands centered between 100-857GHz. Four detectors in each of six bands are coupled to both linear polarizations and thus measure the total intensity. In addition, eight detectors in each of 3 bands (143, 217, and 353GHz) couple only to a single linear polarization and thus provide measurements of the Stokes parameters, Q and U, as well the total intensity. The detectors are required to achieve a Noise Equivalent Power (NEP) at or below the background limit ∼ 10^(-17)W/√Hz for the telescope and time constants of a few ms, short enough to resolve point sources as the 5 to 9 arc-minute beams move across the sky in great circles at 1 rpm. The bolometers are tested at 100mK in a commercial dilution refrigerator with a custom built thermal control system to regulate the heat sink with precision < 100nK/√Hz. The 100mK tests include dark electrical characterization of the load curves, optical and electrical measurement of the thermal time constants and measurement of the noise spectral density from 0.01 to 10Hz for up to 24 bolometers simultaneously
Is the macronutrient intake of formula-fed infants greater than breast-fed infants in early infancy
Faster weight gain early in infancy may contribute to a greater risk of later obesity in formula-fed compared to breast-fed infants. One potential explanation for the difference in weight gain is higher macronutrient intake in formula-fed infants during the first weeks of life. A systematic review was conducted using Medline to assess the macronutrient and energy content plus volume of intake in breast-fed and formula-fed infants in early infancy. All studies from healthy, term, singleton infants reporting values for the composition of breast milk during the first month of life were included. The energy content of colostrum (mean, SEM: 53.6 ± 2.5 kcal/100 mL), transitional milk (57.7 ± 4.2 kcal/100 mL), and mature milk (65.2 ± 1.1 kcal/100 mL) was lower than conventional infant formula (67 kcal/100 mL) on all days analyzed. The protein concentration of colostrum (2.5 ± 0.2 g/100 mL) and transitional milk (1.7 ± 0.1 g/100 mL) was higher than formula (1.4 g/100 mL), while the protein content of mature milk (1.3 ± 0.1 g/100 mL) was slightly lower. Formula-fed infants consume a higher volume and more energy dense milk in early life leading to faster growth which could potentially program a greater risk of long-term obesity
Is the macronutrient intake of formula-fed infants greater than breast-fed infants in early infancy
Faster weight gain early in infancy may contribute to a greater risk of later obesity in formula-fed compared to breast-fed infants. One potential explanation for the difference in weight gain is higher macronutrient intake in formula-fed infants during the first weeks of life. A systematic review was conducted using Medline to assess the macronutrient and energy content plus volume of intake in breast-fed and formula-fed infants in early infancy. All studies from healthy, term, singleton infants reporting values for the composition of breast milk during the first month of life were included. The energy content of colostrum (mean, SEM: 53.6 ± 2.5 kcal/100 mL), transitional milk (57.7 ± 4.2 kcal/100 mL), and mature milk (65.2 ± 1.1 kcal/100 mL) was lower than conventional infant formula (67 kcal/100 mL) on all days analyzed. The protein concentration of colostrum (2.5 ± 0.2 g/100 mL) and transitional milk (1.7 ± 0.1 g/100 mL) was higher than formula (1.4 g/100 mL), while the protein content of mature milk (1.3 ± 0.1 g/100 mL) was slightly lower. Formula-fed infants consume a higher volume and more energy dense milk in early life leading to faster growth which could potentially program a greater risk of long-term obesity
Preliminary performance measurements of bolometers for the Planck high-frequency instrument
We report on the characterization of bolometers fabricated at the Jet Propulsion Laboratory for the High Frequency Instrument (HFI) of the joint ESA/NASA Herschel/Planck mission to be launched in 2007. The HFI is a multicolor focal plane which consists of 48 bolometers operated at 100mK. Each bolometer is mounted to a feedhorn-filter assembly which defines one of six frequency bands centered between 100-857GHz. Four detectors in each of six bands are coupled to both linear polarizations and thus measure the total intensity. In addition, eight detectors in each of 3 bands (143, 217, and 353GHz) couple only to a single linear polarization and thus provide measurements of the Stokes parameters, Q and U, as well the total intensity. The detectors are required to achieve a Noise Equivalent Power (NEP) at or below the background limit ∼ 10^(-17)W/√Hz for the telescope and time constants of a few ms, short enough to resolve point sources as the 5 to 9 arc-minute beams move across the sky in great circles at 1 rpm. The bolometers are tested at 100mK in a commercial dilution refrigerator with a custom built thermal control system to regulate the heat sink with precision < 100nK/√Hz. The 100mK tests include dark electrical characterization of the load curves, optical and electrical measurement of the thermal time constants and measurement of the noise spectral density from 0.01 to 10Hz for up to 24 bolometers simultaneously
Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder
An unanticipated and tremendous amount of the noncoding sequence of the human genome is transcribed. Long noncoding RNAs (lncRNAs) constitute a significant fraction of non-protein-coding transcripts; however, their functions remain enigmatic. We demonstrate that deletions of a small noncoding differentially methylated region at 16q24.1, including lncRNA genes, cause a lethal lung developmental disorder, alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV), with parent-of-origin effects. We identify overlapping deletions 250 kb upstream of FOXF1 in nine patients with ACD/MPV that arose de novo specifically on the maternally inherited chromosome and delete lung-specific lncRNA genes. These deletions define a distant cis-regulatory region that harbors, besides lncRNA genes, also a differentially methylated CpG island, binds GLI2 depending on the methylation status of this CpG island, and physically interacts with and up-regulates the FOXF1 promoter. We suggest that lung-transcribed 16q24.1 lncRNAs may contribute to long-range regulation of FOXF1 by GLI2 and other transcription factors. Perturbation of lncRNA-mediated chromatin interactions may, in general, be responsible for position effect phenomena and potentially cause many disorders of human development