The rare and the unexpected; Miller Fisher Syndrome

Miller Fisher Syndrome (MFS) is a rare variant of Guillain-Barré syndrome (GBS) which is an idiopathic neuromuscular paralysis. It is considered as autoimmune disease because there are antibodies which attack the nerve cell fibers resulting in paralysis of muscles. This disease exhibits a classic clinical triad of ataxia,areflexia, and ophthalmoplegiawhereas it could have more neurological symptoms.Basically it is diagnosed clinically but have a serological test for its confirmation i.e. anti-GQ1b antibody levels.Here, we report a stereotypical case of MFS with all of its cardinal symptoms with addition of some other symptoms like diplopia, ptosis of an eye and unilateral facial nerve palsy. This patient presented with all of these signs and symptoms preceded by an upper respiratory tract illness. The suspected diagnosis was aided with itsserological marker anti-GQ1b antibody levels and nerve conduction studies(NCS)/electromyographic(EMG)studies and the patient was successfully treated with multiple sessions of plasmapheresis and reduction in severity of the disease was noticed

Neuromyelitis Optica (nmo); A case report

Devic’s disease or syndrome also known as Neuromyelitis optica (NMO) which is a demyelinating central nervous system (immune-mediated) ailment that predominantly targets the optic nerves and spinal cord. NMO-IgG seropositivity & longitudinally extensive spinal-cord lesions typically represents the Devic’s disease & differentiates it from Multiple Sclerosis (MS).Treatment for NMO is based upon its presentation such as for acute phase(steroids, IVIG etc), prevention of relapse (steroid sparing immunosuppression etc) and symptom based therapy (e.g spasticity etc). Here, we present a case of NMO in a young female (26 years old), married patient who presented to us with total vision loss, urinary & fecal incontinence & paraplegia. She was being treated as a case of Multiple Sclerosis (MS) several years ago but we further investigated & found NMO-IgG seropositivity and other findings in the history that conforms the diagnostic criteria of NMOSD for this patient. Furthermore, the patient was treated with IV glucocorticoids for its acute phase of disease & sent home when symptoms of transverse myelitis improved

AN INVESTIGATION INTO THREE DIMENSIONAL TURBULENT FLOW OF NEWTONIAN LIQUID IN STIRRED TANKS MIXERS

The present work is concerned with the theoretical and experimental investigation of flow pattern of Newtonian fluid in liquid mixing process in stirred tank with flat blade impeller. A threedimensional model for mixing process was simulated. The effected parameters are rotation speed and impeller diameter. Continuity, momentum, and turbulent equations were solved by ANSYS package software 5.4 code with FLOTRAN/CFD based on Finite Element method. In the experimental work, two visualization methods are used in this work, the first method is the acidbase reaction visualization method and the second is the particle distribution visualization method. Different chemical materials were used in the first method, NaOH as a base, 2 4 H SO as acid and Methyl red as indicator, while polymer particles were used in the second method. The results of 3D model showed that the speed rotation directly affected the mixing zones, where the speed reduction by half decreasing the mixing zones approximately by half. Also the impeller diameter increasing clearly affected the mixing process where the mixing zones concentrated directly above and below the impeller. In the experimental work, the acid-base reaction visualization method showed that the mixing zones decreased due to the rotation speed reduction depend on the red and yellow colors, which describe the good mixing and poor mixing zones respectively. The mixing zones were concentrated directly above and below the impeller due to the impeller diameter increasing,. The particles distribution method showed that the mixing zones decreased due to the speed reduction, while the mixing zones concentrated directly above and below the impeller due to the impeller diameter increasing. The results showed a good agreement between the theoretical and experimental works in studying the effect of rotating speed, and impeller diameter