Hypoglycemic Effect of Selected Herbal Extracts on Streptozotocin Induced Diabetic Rats

Abstract: This study was carried out to investigate the most effective compounds extracted from approved selected antidiabetic plants on control blood glucose, serum insulin, lipid profile level and protective effect against oxidative stress in streptozotocin induced diabetic rats. Method: 70 albino rats were divided into 7 groups 10 rats each. Group ² normal control, group Ï diabetic control, group Ø received essential onion oil (100mg/kg b.w. orally), group ²V received alkaloids of lupin (100mg/kg b.w. orally), group V, group V² received anthocyanins of cinnamon and mulberry respectively (16 mg/kg b.w. orally) and group VÏ received their combination together (58 mg/kg b.w. orally) for 21 days. At the end of experiment Blood glucose, insulin levels, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol were estimated. Oxidative stress biomarkers represented in the amount of thiobarbituric acid reactive substances (TBARS) and nitric oxide were determined. Liver and kidney removed for histopathological examination. Results: All isolated compound improved diabetes status but the most potent antidiabetic effect was observed in combination of all compounds. W hile onion essential oil had both antioxdiabetic and antioxidant effect. Conculsion: These results suggest that administration of the combined drug and essential onion oil used as antidiabetic agent and improved diabetic status