Manpower Planning: Goals, Methods, and a Suggested Stragegy for CETA Prime Sponsors

The purpose of this thesis is to provide information concerning government planning to reduce unemployment with the U. S. The research presented here is directed toward the individual with some interest in manpower planning at the most localized level of government. As a part of the above objective, this work seeks to familiarize the individual with the history of government efforst in the area of employment, the CETA program, and a perspective of future local planning in the area of manpower services. Chapter I of this thesis is an introduction which outlines the purposes, scope, and limitations of this study. Chapter II discusses the current problem of unemployment within the U.S. and the major issues concerning the role of government in dealing with the problem. Chapter III presents a brief history of U. S. employment and government legislation up through the reauthorization of the Comprehensive Employment and Training Act in 1978. Chapter IV delineates some of the major decisions which are within the purview of local manpower planners and the correlations between these decision and levels of program success or failure. Chapter V, the final chapter of the thesis, proposes a basic strategy for future manpower planning at the local level, based upon the research included in the first four chapters

Learning with a Purpose: Academic Service-Learning Curriculum

The Dwight D. Eisenhower Professional Development Program is authorized under Title II of P. L. 103-382. It provides institutions of higher education the opportunity to partner with K-12 teachers and administrators to assist with professional development through sustained, high-quality professional development activities in mathematics, science, reading, and other areas of the core academic curriculum. The Dwight D. Eisenhower Professional Development project shared here was undertaken by Eastern Michigan University and Romulus Community Schools to provide Romulus teachers professional development to integrate the teaching methodology of academic service-learning into their mathematics and science curriculum. The goal was to increase academic achievement and civic participation. This monograph contains sample units and lesson plans produced by teachers who participated in this grant

Emission spectrochemical analysis of impurities in plutonium dioxide.

A description is given of a method used at the A.A.E.C. Research Establishment for the analysis of impurities in plutonium dioxide. Plutonium is separated from its impurities by adsorption on to anion - exchange resin. The effluent containing the impurities is spectrographically analyzed using a graphite spark technique. Pyrolytic graphite electrodes which are non-porous and do not require sealing are used in preference to the normal greased electrodes which are unsuitable for the analysis of acidic solutions. The plutonium is analyzed for Fe, Al, Mg, Mn, Ni, Cr, Pb, Cd, Co, Ca, Sn, Mo, and Zn using vanadium as internal standard. The overall precision of the method is estimated to be + 20 per cent

Validation of the GENEA accelerometer

Purpose: The study aims were: 1) to assess the technical reliability and validity of the GENEA using a mechanical shaker; 2) to perform a GENEA value calibration to develop thresholds for sedentary and light-, moderate-, and vigorous-intensity physical activity; and 3) to compare the intensity classification of the GENEA with two widely used accelerometers. Methods: A total of 47 GENEA accelerometers were attached to a shaker and vertically accelerated, generating 15 conditions of varying acceleration and/or frequency. Reliability was calculated using SD and intrainstrument and interinstrument coefficients of variation, whereas validity was assessed using Pearson correlation with the shaker acceleration as the criterion. Next, 60 adults wore a GENEA on each wrist and on the waist (alongside an ActiGraph and RT3 accelerometer) while completing 10-12 activity tasks. A portable metabolic gas analyzer provided the criterion measure of physical activity. Analyses involved the use of Pearson correlations to establish criterion and concurrent validity and receiver operating characteristic curves to establish intensity cut points. Results: The GENEA demonstrated excellent technical reliability (CVintra = 1.4%, CVinter = 2.1%) and validity (r = 0.98, P < 0.001) using the mechanical shaker. The GENEA demonstrated excellent criterion validity using V̇O as the criterion (left wrist, r = 0.86; right wrist, r = 0.83; waist, r = 0.87), on par with the waist-worn ActiGraph and RT3. The GENEA demonstrated excellent concurrent validity compared with the ActiGraph (r = 0.92) and the RT3 (r = 0.97). The waist-worn GENEA had the greatest classification accuracy (area under the receiver operating characteristic curve (AUC) = 0.95), followed by the left (AUC = 0.93) and then the right wrist (AUC = 0.90). The accuracy of the waist-worn GENEA was virtually identical with that of the ActiGraph (AUC = 0.94) and RT3 (AUC = 0.95). CONCLUSION:: The GENEA is a reliable and valid measurement tool capable of classifying the intensity of physical activity in adults. © 2011 by the American College of Sports Medicine

VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG

<p>Abstract</p> <p>Background</p> <p>This work tests the hypothesis that increased levels of vascular endothelial growth factor (VEGF) observed during bladder inflammation modulates nerve plasticity.</p> <p>Methods</p> <p>Chronic inflammation was induced by intravesical instillations of Bacillus Calmette-Guérin (BCG) into the urinary bladder and the density of nerves expressing the transient receptor potential vanilloid subfamily 1 (TRPV1) or pan-neuronal marker PGP9.5 was used to quantify alterations in peripheral nerve plasticity. Some mice were treated with B20, a VEGF neutralizing antibody to reduce the participation of VEGF. Additional mice were treated systemically with antibodies engineered to specifically block the binding of VEGF to NRP1 (anti-NRP1^B) and NRP2 (NRP2^B), or the binding of semaphorins to NRP1 (anti-NRP1 ^A) to diminish activity of axon guidance molecules such as neuropilins (NRPs) and semaphorins (SEMAs). To confirm that VEGF is capable of inducing inflammation and neuronal plasticity, another group of mice was instilled with recombinant VEGF₁₆₅or VEGF₁₂₁into the urinary bladder.</p> <p>Results</p> <p>The major finding of this work was that chronic BCG instillation resulted in inflammation and an overwhelming increase in both PGP9.5 and TRPV1 immunoreactivity, primarily in the sub-urothelium of the urinary bladder. Treatment of mice with anti-VEGF neutralizing antibody (B20) abolished the effect of BCG on inflammation and nerve density.</p> <p>NRP1^Aand NRP1^Bantibodies, known to reduce BCG-induced inflammation, failed to block BCG-induced increase in nerve fibers. However, the NRP2^Bantibody dramatically potentiated the effects of BCG in increasing PGP9.5-, TRPV1-, substance P (SP)-, and calcitonin gene-related peptide (CGRP)-immunoreactivity (IR). Finally, instillation of VEGF₁₂₁or VEGF₁₆₅into the mouse bladder recapitulated the effects of BCG and resulted in a significant inflammation and increase in nerve density.</p> <p>Conclusions</p> <p>For the first time, evidence is being presented supporting that chronic BCG instillation into the mouse bladder promotes a significant increase in peripheral nerve density that was mimicked by VEGF instillation. Effects of BCG were abolished by pre-treatment with neutralizing VEGF antibody. The present results implicate the VEGF pathway as a key modulator of inflammation and nerve plasticity, introduces a new animal model for investigation of VEGF-induced nerve plasticity, and suggests putative mechanisms underlying this phenomenon.</p

Endosymbiosis: Lessons in Conflict Resolution

Endosymbiotic bacteria live within a host species. There are many and diverse examples of such relationships, the study of which provides important lessons for ecology and evolutio

Intravenous vortioxetine to accelerate onset of effect in major depressive disorder: a 7-day randomized, double-blind, placebo-controlled exploratory study

Publisher Copyright: © 2020 Lippincott Williams and Wilkins. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.This 7-day randomized, double-blind, placebo-controlled fixed-dose study (NCT03766867) explored the potential for accelerating the onset of antidepressant efficacy of single-dose intravenous (IV) vortioxetine at oral vortioxetine treatment initiation. Patients (ages 18-65 years) hospitalized per standard-of-care with major depressive disorder, who were currently treated with a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor for a major depressive episode [Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥ 30], received one dose of single-blind IV placebo (1-day placebo lead-in period) before being randomly switched to either single-dose IV vortioxetine 25 mg plus daily oral vortioxetine 10 mg (n = 39), or IV placebo plus daily oral placebo (n = 41). In the placebo lead-in period, patients improved slightly by 0.6 MADRS-6 point; however, at day 1 after randomization, both treatment groups had improved by approximately 3 MADRS-6 points (mean difference =-0.8; P = 0.263), the study thus not meeting its primary endpoint. Similar results were seen for other outcomes except a numerically larger improvement in anxiety symptoms with vortioxetine vs placebo. Pharmacokinetic data confirmed that IV vortioxetine facilitated reaching steady-state plasma concentration within 24 h. IV plus oral vortioxetine was well tolerated, with low levels of nausea as the most common adverse event.publishersversionPeer reviewe

Incentive compatibility and conflict resolution in international river basins: A case study of the Nile basin

10.1029/2005WR004238Water Resources Research422WRER