Virtual Reality-Based Psychotherapy in Social Anxiety Disorder: fMRI Study Using a Self-Referential Task

Background: Although it has been well demonstrated that the efficacy of virtual reality therapy for social anxiety disorder is comparable to that of traditional cognitive behavioral therapy, little is known about the effect of virtual reality on pathological self-referential processes in individuals with social anxiety disorder. Objective: We aimed to determine changes in self-referential processing and their neural mechanisms following virtual reality treatment. Methods: We recruited participants with and without a primary diagnosis of social anxiety disorder to undergo clinical assessments (Social Phobia Scale and Post-Event Rumination Scale) and functional magnetic resonance imaging (fMRI) scans. Participants with social anxiety disorder received virtual reality-based exposure treatment for 6 sessions starting immediately after baseline testing. After the sixth session, participants with social anxiety disorder completed follow-up scans during which they were asked to judge whether a series of words (positive, negative, neutral) was relevant to them. Results: Of 25 individuals with social anxiety disorder who participated in the study, 21 completed the sessions and follow-up; 22 control individuals also participated. There were no significant differences in age (P=.36), sex (P=.71), or handedness (P=.51) between the groups. Whole-brain analysis revealed that participants in the social anxiety disorder group had increased neural responses during positive self-referential processing in the medial temporal and frontal cortexes compared with those in the control group. Participants in the social anxiety disorder group also showed increased left insular activation and decreased right middle frontal gyms activation during negative self-referential processing. After undergoing virtual reality based therapy, overall symptoms of the participants with social anxiety disorder were reduced, and these participants exhibited greater activity in a brain regions responsible for self-referential and autobiographical memory processes while viewing positive words during postintervention fMRI scans. Interestingly, the greater the blood oxygen level dependent changes related to positive self-referential processing, the lower the tendency to ruminate on the negative events and the lower the social anxiety following the virtual reality session. Compared with that at baseline, higher activation was also found within broad somatosensory areas in individuals with social anxiety disorder during negative self-referential processing following virtual reality therapy. Conclusions: These fMRI findings might reflect the enhanced physiological and cognitive processing in individuals with social anxiety disorder in response to self-referential information. They also provide neural evidence of the effect of virtual reality exposure therapy on social anxiety and self-derogation

Prediction of Specific Anxiety Symptoms and Virtual Reality Sickness Using In Situ Autonomic Physiological Signals During Virtual Reality Treatment in Patients With Social Anxiety Disorder: Mixed Methods Study

Background: Social anxiety disorder (SAD) is the fear of social situations where a person anticipates being evaluated negatively. Changes in autonomic response patterns are related to the expression of anxiety symptoms. Virtual reality (VR) sickness can inhibit VR experiences. Objective: This study aimed to predict the severity of specific anxiety symptoms and VR sickness in patients with SAD, using machine learning based on in situ autonomic physiological signals (heart rate and galvanic skin response) during VR treatment sessions. Methods: This study included 32 participants with SAD taking part in 6 VR sessions. During each VR session, the heart rate and galvanic skin response of all participants were measured in real time. We assessed specific anxiety symptoms using the Internalized Shame Scale (ISS) and the Post-Event Rumination Scale (PERS), and VR sickness using the Simulator Sickness Questionnaire (SSQ) during 4 VR sessions (#1, #2, #4, and #6). Logistic regression, random forest, and naive Bayes classification classified and predicted the severity groups in the ISS, PERS, and SSQ subdomains based on in situ autonomic physiological signal data. Results: The severity of SAD was predicted with 3 machine learning models. According to the F1 score, the highest prediction performance among each domain for severity was determined. The F1 score of the ISS mistake anxiety subdomain was 0.8421 using the logistic regression model, that of the PERS positive subdomain was 0.7619 using the naive Bayes classifier, and that of total VR sickness was 0.7059 using the random forest model. Conclusions: This study could predict specific anxiety symptoms and VR sickness during VR intervention by autonomic physiological signals alone in real time. Machine learning models can predict the severe and nonsevere psychological states of individuals based on in situ physiological signal data during VR interventions for real-time interactive services. These models can support the diagnosis of specific anxiety symptoms and VR sickness with minimal participant bias

“Emotional Exhaustion and Perceived Corporate Social Responsibility: A Case Study of a Port Logistics Organization”

In an era of economic crisis, and at the shadow of major ethical scandals in organizations, Corporate Social Responsibility (CSR) strategy has emerged as a crucial element to reestablish the bond between corporations and all other stakeholders such as the local community, society and labor force. Crisis makes employees more stressful, since they work on unwarranted jobs causing them emotional exhaustion. This study aims to examine the association between employee emotional exhaustion and perceived corporate social responsibility (CSR). For this purpose, this study conducted a survey which examines if CSR (ethical, social, environmental dimensions) is negatively related to emotional exhaustion of employees on a sample of 93 employees of a port logistics management services organization. A structured questionnaire was developed in order to measure emotional exhaustion and employee perceptions about CSR activities. Building on the claim that employee perceptions of CSR activities may significantly related to emotional state, this paper examines three CSR dimensions (social, ethical and environmental) and emotional exhaustion. The results of this study indicate that environmental CSR exerts a negative significant effect on Emotional exhaustion. These finding will be of great value as they can contribute on understanding the impact of environmental CSR on emotional exhaustion with detrimental effects on employees’ productivity, job performance, and creativity. The importance of CSR environmental aspects and the relative strategies guiding CSR impact on emotional exhaustion affecting job-related outcomes are also discussed

TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution

R-loops are three-stranded, RNA???DNA hybrid, nucleic acid structures produced due to inappropriate processing of newly transcribed RNA or transcription-replication collision (TRC). Although R-loops are important for many cellular processes, their accumulation causes genomic instability and malignant diseases, so these structures are tightly regulated. It was recently reported that R-loop accumulation is resolved by methyltransferase-like 3 (METTL3)-mediated m6A RNA methylation under physiological conditions. However, it remains unclear how R-loops in the genome are recognized and induce resolution signals. Here, we demonstrate that tonicity-responsive enhancer binding protein (TonEBP) recognizes R-loops generated by DNA damaging agents such as ultraviolet (UV) or camptothecin (CPT). Single-molecule imaging and biochemical assays reveal that TonEBP preferentially binds a R-loop via both 3D collision and 1D diffusion along DNA in vitro. In addition, we find that TonEBP recruits METTL3 to R-loops through the Rel homology domain (RHD) for m6A RNA methylation. We also show that TonEBP recruits RNaseH1 to R-loops through a METTL3 interaction. Consistent with this, TonEBP or METTL3 depletion increases R-loops and reduces cell survival in the presence of UV or CPT. Collectively, our results reveal an R-loop resolution pathway by TonEBP and m6A RNA methylation by METTL3 and provide new insights into R-loop resolution processes

Seismic Strengthening of RC Structures Using Wall-Type Kagome Damping System

In this study, the Kagome truss damper, a metallic wire structures, was introduced and its mechanical properties were investigated through theoretical analyses and experimental tests. The yield strength of the Kagome damper is dependent on the geometric shape and diameter of the metallic wire. The Kagome damper has higher resistance to plastic buckling as well as lower anisotropy. Cyclic shear loading tests were conducted to investigate the energy dissipation capacity and stiffness/strength degradation by repeated loadings. The hysteretic properties obtained from the tests suggest that a modification of the ideal truss model with a hinged connection could be used to predict the yield strength and stiffness of the damper. For seismic retrofitting of a low-rise RC moment frame system, a wall-type Kagome damping system (WKDS) was proposed. The effectiveness of the proposed system was verified by conducting cyclic loading tests using a RC frame with/without the WKDS (story drift ratio limit 1.0%). The test results indicated that both the strength and stiffness of the RC frame increased to the target level and that its energy dissipation capacity was significantly enhanced. Nonlinear static and dynamic analyses were carried out to validate that the existing building structure can be effectively retrofitted using the proposed WKDS

Seismic Performance of Story-Added Type Buildings Remodeled with Story Seismic Isolation Systems

Story-added type apartments have recently been introduced as an option to resolve the housing supply shortage in areas that are undergoing rapid industrialization and urbanization. However, the infrastructure of old apartment buildings (>20 years old) makes it difficult to introduce convenient facilities and recent technologies such as those involving the Internet of Things and augmented realities. Applying housing technologies to existing older apartments can increase housing supply and potentially address the aforementioned issues. However, story-added building remodeling increases the weight of existing buildings, necessitating seismic reinforcement, which is the major obstacle when performing vertical building extensions. This study presents methods for lowering seismic loads associated with vertical augmentation of buildings while improving the seismic performance. A model of a vertically extended building with three additional stories constructed on top of an existing 15-story apartment building was used. The applied seismic isolation system decreased the maximum response acceleration on top of the remodeled building by approximately 70% and 65% in the X-direction and Y-direction, respectively, while decreasing the base shear plane by approximately 30% in both the X- and Y-directions in comparison with forces on a non-seismically isolated building. These results demonstrate that the use of a seismic isolation system can significantly reduce seismic loads

Seismic Performance of Story-Added Type Buildings Remodeled with Story Seismic Isolation Systems

Story-added type apartments have recently been introduced as an option to resolve the housing supply shortage in areas that are undergoing rapid industrialization and urbanization. However, the infrastructure of old apartment buildings (>20 years old) makes it difficult to introduce convenient facilities and recent technologies such as those involving the Internet of Things and augmented realities. Applying housing technologies to existing older apartments can increase housing supply and potentially address the aforementioned issues. However, story-added building remodeling increases the weight of existing buildings, necessitating seismic reinforcement, which is the major obstacle when performing vertical building extensions. This study presents methods for lowering seismic loads associated with vertical augmentation of buildings while improving the seismic performance. A model of a vertically extended building with three additional stories constructed on top of an existing 15-story apartment building was used. The applied seismic isolation system decreased the maximum response acceleration on top of the remodeled building by approximately 70% and 65% in the X-direction and Y-direction, respectively, while decreasing the base shear plane by approximately 30% in both the X- and Y-directions in comparison with forces on a non-seismically isolated building. These results demonstrate that the use of a seismic isolation system can significantly reduce seismic loads

Performance Evaluation of Seismic Isolation System by Installation Location in Lighthouse Structures

The purpose of this study is to evaluate the applicability of seismic isolation devices for marine accidents under seismic loads. The lighthouse structure is a very important facility when the ship approaches the port. However, it is necessary to reinforce the structure to protect it from earthquake. This study presents isolation technology as a method to enhance the seismic performance of lighthouse structures built before seismic design criteria were established. This paper analyzed improvement of seismic performance in three cases of seismic isolation by applying the proposed method of isolation technology. In Case 1, the entire lighthouse structure is isolated, and in Case 2, only the lighthouse lens, the most important component of the lighthouse structure, has been isolated to assure constructability and economy. In Case 3, isolation effect was analyzed by comparing Case 1 and Case 2 with lighthouse structures

When Do Service Employees Suffer More from Job Insecurity? The Moderating Role of Coworker and Customer Incivility

The present study examines the effect of service employees’ job insecurity on job performance through emotional exhaustion. We identified workplace incivility (i.e., coworker and customer incivility) as a boundary condition that strengthens the positive relationship between job insecurity and emotional exhaustion. To test this moderating effect, we collected online panel surveys from 264 Korean service employees at two time points three months apart. As predicted, the positive relationship between job insecurity and job performance was partially mediated by emotional exhaustion. Of the two forms of workplace incivility, only coworker incivility exerted a significant moderating effect on the job insecurity–emotional exhaustion relationship, such that this relationship was more pronounced when service employees experienced a high level of coworker incivility than when coworker incivility was low. Coworker incivility further moderated the indirect effect of job insecurity on job performance through emotional exhaustion. These findings have theoretical implications for job insecurity research and managerial implications for practitioners

Corporate Brand Trust as a Mediator in the Relationship between Consumer Perception of CSR, Corporate Hypocrisy, and Corporate Reputation

The aim of this research is to investigate the relationship between consumer perception of Corporate Social Responsibility (CSR), corporate brand trust, corporate hypocrisy, and corporate reputation. Based on the one-to-one interview method using a structured questionnaire of 560 consumers in South Korea, the proposed model was estimated by structural equation modeling analysis. The model suggests that consumer perception of CSR influences consumer attitudes toward a corporation (i.e., perceived corporate hypocrisy and corporate reputation) by developing corporate brand trust. This in turn further enhances corporate reputation while decreasing corporate hypocrisy. The findings of our study demonstrate that consumer perception of CSR is an antecedent to corporate brand trust, which fully mediates the relationship between consumer perception of CSR and corporate reputation. In addition, corporate brand trust has the role of partial mediator in the relationship between consumer perception of CSR and corporate hypocrisy. These results imply that to better understand the relationship between consumer perception of CSR and consumer attitudes toward a corporation, it is necessary to consider corporate brand trust as an important mediating variable. The theoretical and practical implications of this study are discussed, together with its limitations and potential for future research