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Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice
The aim of the present study was to evaluate the protective activity of aqueous extract
from Platycodon grandiflorum (BC703) on thioacetamide (TA)-induced
hepatotoxicity in mice. We found that BC703 significantly decreased mortality and the
change in serum transaminase following TA administration. The group treated with BC703 at
doses of 1, 5, and 10β
mg/kg produced significant hepatoprotective effects against
TA-induced liver damage by decreasing the activities of serum enzymes, nitric oxide and
lipid peroxidation in dose-dependent manners. Histopathological studies further
substantiated the protective effect of BC703. These results show the hepatoprotective
activity of aqueous extract from Platycodon grandiflorum on
thioacetamide-induced fulminant hepatic failure