Inclusion and Exclusion Criterion of the Parent Study.

<p>Inclusion and Exclusion Criterion of the Parent Study.</p

Study Population and Exclusion Criteria.

<p>Study Population and Exclusion Criteria.</p

Demographics of Supine vs. Prone Groups.

<p>* Sample sizes for supine and prone were 37 and 31, respectively.</p><p>Data are presented as mean (± SD), median [IQR] or N(%).</p><p>Demographics of Supine vs. Prone Groups.</p

Supine vs. Prone: Comparison of Desaturation at 3 Thresholds.

<p>*Data are presented as median [IQR] time in minutes spent below the threshold and percent of total patients who experienced any time under the threshold.</p><p>Supine vs. Prone: Comparison of Desaturation at 3 Thresholds.</p

Supplemental Material - A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin-Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay

Supplemental Material for A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin–Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay by Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo, and Natalie K. Smith in Seminars in Cardiothoracic and Vascular Anesthesia</p

Supplemental Material - A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin-Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay

Supplemental Material for A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin-Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay by Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo, and Natalie K. Smith in Seminars in Cardiothoracic and Vascular Anesthesia</p

Image_1_Alzheimer’s Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes.pdf

ObjectivesMultiple risk loci for late-onset Alzheimer’s disease (LOAD) have been identified. Type 2 diabetes (T2D) is a risk factor for cognitive decline, dementia and Alzheimer’s disease (AD). We investigated the association of polygenic risk score (PRS) for LOAD with overall cognitive functioning and longitudinal decline, among older adults with T2D.MethodsThe study included 1046 Jewish participants from the Israel Diabetes and Cognitive Decline (IDCD) study, aged ≥ 65 years, diagnosed with T2D, and cognitively normal at baseline. The PRS included variants from 26 LOAD associated loci (at genome-wide significance level), and was calculated with and without APOE. Outcome measures, assessed in 18 months intervals, were global cognition and the specific domains of episodic memory, attention/working memory, executive functions, and language/semantic categorization. Random coefficient models were used for analysis, adjusting for demographic variables, T2D-related characteristics, and cardiovascular factors. Additionally, in a subsample of 202 individuals, we analyzed the association of PRS with the volumes of total gray matter, frontal lobe, hippocampus, amygdala, and white matter hyperintensities. Last, the association of PRS with amyloid beta (Aβ) burden was examined in 44 participants who underwent an 18F-flutemetamol PET scan.ResultsThe PRS was not significantly associated with overall functioning or decline in global cognition or any of the specific cognitive domains. Similarly, following correction for multiple testing, there was no association with Aβ burden and other brain imaging phenotypes.ConclusionOur results suggest that the cumulative effect of LOAD susceptibility loci is not associated with a greater rate of cognitive decline in older adults with T2D, and other pathways may underlie this link.</p