Gut microbiota alterations are associated with functional outcomes in patients of acute ischemic stroke with non-alcoholic fatty liver disease

IntroductionPatients with acute ischemic stroke (AIS) with non-alcoholic fatty liver disease (NAFLD) frequently have poor prognosis. Many evidences suggested that the changes in gut microbiota may play an important role in the occurrence and development of AIS patients with NAFLD. The purpose of this study was to explore microbial characteristics in patients of AIS with NAFLD, and the correlation between gut microbiota and functional outcomes.MethodsThe patients of AIS were recruited and divided into NAFLD group and non-NAFLD group. The stool samples and clinical information were collected. 16 s rRNA sequencing was used to analyze the characteristics of gut microbiota. The patients of AIS with NAFLD were followed-up to evaluate the functional outcomes of disease. The adverse outcomes were determined by modified Rankin scale (mRS) scores at 3 months after stroke. The diagnostic performance of microbial marker in predicting adverse outcomes was assessed by recipient operating characteristic (ROC) curves.ResultsOur results showed that the composition of gut microbiota between non-NAFLD group and NAFLD group were different. The characteristic bacteria in the patients of AIS with NAFLD was that the relative abundance of Dorea, Dialister, Intestinibacter and Flavonifractor were decreased, while the relative abundance of Enorma was increased. Moreover, the characteristic microbiota was correlated with many clinical parameters, such as mRS scores, mean arterial pressure and fasting blood glucose level. In addition, ROC models based on the characteristic microbiota or the combination of characteristic microbiota with independent risk factors could distinguish functional dependence patients and functional independence patients in AIS with NAFLD (area under curve is 0.765 and 0.882 respectively).ConclusionThese findings revealed the microbial characteristics in patients of AIS with NAFLD, and further demonstrated the predictive capability of characteristic microbiota for adverse outcomes in patients of AIS with NAFLD

Statistical Bias Correction For Creating Coherent Total Ozone Record From Omi And Omps Observations

A long-term coherent total column ozone (TCO) record is essential to ozone layer variability assessment, especially the detection of early signs of ozone recovery after years of depletion. Because of differences in satellite platforms and instruments design, calibration, and retrieval algorithms, however, significant cross-mission biases are observed between multiple sensor TCO observations in the common time-space domain. To attain a coherent TCO record, observed cross-mission biases should be accurately addressed prior to the data-merging scheme. In this study, a modified statistical bias correction method was proposed based on the quantile-quantile adjustment to remove apparent cross-mission TCO biases between the Ozone Monitoring Instrument (OMI) and Ozone Mapping and Profiler Suite (OMPS). To evaluate the effectiveness of this modified algorithm, the overall inconsistency (OI), a unique time-series similarity measure, was proposed to quantify the improvements of consistency (or similarity) between cross-mission TCO time series data before and after bias correction. Common observations during the overlapped time period of 2012-2015 were used to characterize the systematic bias between OMPS and OMI through the modified bias correction method. TCO observations from OMI during 2004-2015 were then projected to the OMPS level by removing associated cross-mission biases. This modified bias correction scheme significantly improved the overall consistency, with an average improvement of 90% during the overlapped time period at the global scale. In addition to the evaluation of consistency improvements before and after bias correction, impacts of cross-mission biases on long-term trend estimations were also investigated. Comparisons of derived trends from the merged TCO time series before and after bias correction across 38 ground-based stations indicate that cross-mission biases not only affect magnitudes of estimated trends, but also result in different phases of trends. Further comparisons of estimated seasonal TCO trends before and after bias correction at the global scale suggest that trends derived from the bias-corrected time series are more accurate than those without bias correction. Overall, the bias correction scheme developed in this study is essential for preparing an accurate long-term TCO record representative of trend analysis to support future assessment of ozone recovery at the global scale

An Intercomparison Of Multidecadal Observational And Reanalysis Data Sets For Global Total Ozone Trends And Variability Analysis

A four-step adaptive ozone trend estimation scheme is proposed by integrating multivariate linear regression (MLR) and ensemble empirical mode decomposition (EEMD) to analyze the long-term variability of total column ozone from a set of four observational and reanalysis total ozone data sets, including the rarely explored ERA-Interim total ozone reanalysis, from 1979 to 2009. Consistency among the four data sets was first assessed, indicating a mean relative difference of 1% and root-mean-square error around 2% on average, with respect to collocated ground-based total ozone observations. Nevertheless, large drifts with significant spatiotemporal inhomogeneity were diagnosed in ERA-Interim after 1995. To emphasize long-term trends, natural ozone variations associated with the solar cycle, quasi-biennial oscillation, volcanic aerosols, and El Niño-Southern Oscillation were modeled with MLR and then removed from each total ozone record, respectively, before performing EEMD analyses. The resulting rates of change estimated from the proposed scheme captured the long-term ozone variability well, with an inflection time of 2000 clearly detected. The positive rates of change after 2000 suggest that the ozone layer seems to be on a healing path, but the results are still inadequate to conclude an actual recovery of the ozone layer, and more observational evidence is needed. Further investigations suggest that biases embedded in total ozone records may significantly impact ozone trend estimations by resulting in large uncertainty or even negative rates of change after 2000

Tricyclic Diester and 2,5-Furandicarboxylic Acid for the Synthesis of Biobased Hydrolysis Copolyesters with High Glass Transition Temperatures

The reluctance of a polyester with high glass transition temperature (Tg) and mechanical properties to hydrolyze is a well-known fact, for instance, the high hydrolysis resistance of aromatic polyesters based on terephthalic acid and 2,5-furandicarboxylic acid (FDCA). The synthesis of polyesters that have a high Tg (>100 °C) and a fast hydrolytic degradation quality at the same time is a valuable topic. Herein, a renewable rigid diester, N,N′-trans-1,4-cyclohexane-bis(pyrrolidone-4-methyl carboxylate) (CBPC), was obtained via Michael addition. CBPC was copolymerized with FDCA and ethylene glycol to prepare a series of copolyesters PECxEFy with a high Mn over 30 kDa. PECxEFy showed a Tg range of 75.2–109.2 °C which outdistanced the most biobased polyesters. The thermal stability of all PECxEFy remained unchanged with the introduction of CBPC. Moreover, PECxEFy presented superior mechanical performances which were matching or exceeding those of commercial polyethylene terephthalate (PET) and polylactic acid (PLA). PECxEFy was stable in air but was able to undergo noticeable hydrolytic degradation, proving their enhanced degradability. And the regulation between CBPC and FDCA composition can be leveraged to adjust the degradation and environmental durability of PECxEFy, up to practical applications. Computational studies systematically revealed the relationship between CBPC with a tricyclic structure and the improved Tg and hydrolyzation properties. The outstanding thermal and mechanical performances and hydrolysis of these copolyesters appear to be promising candidates for renewable alternatives to industrial petrochemical polyesters

Effect of early mobilization combined with early nutrition on acquired weakness in critically ill patients (EMAS): A dual-center, randomized controlled trial.

AimThe study aimed to investigate the effect of early mobilization combined with early nutrition (EMN) on intensive care unit-acquired weakness (ICU-AW) in intensive care unit (ICU) settings compared with early mobilization (EM) or routine care.MethodsA prospective, dual-center, randomized controlled trial was conducted. The control group underwent standard care without a pre-established routine for mobilization and nutrition. The EM group underwent early, individualized, progressive mobilization within 24 h of ICU admission. The EMN group underwent early mobilization, similar to the EM group plus guideline-based early nutrition (within 48 h of ICU admission). The primary outcome was the occurrence of ICU-AW at discharge from the ICU. Secondary outcomes included muscle strength, functional independence, organ failure, nutritional status, duration of mechanical ventilation (MV), length of ICU stay, and ICU mortality at ICU discharge.ResultsA total of 150 patients were enrolled and equally distributed into the three groups. Patients undergoing routine care only were more susceptible to ICU-AW upon ICU discharge than those in the EM or EMN groups (16% vs. 2%; p = 0.014 for both), and had a lower Barthel Index than others (control vs. EM/EMN: 57.5 vs 70.0; p = 0.022). The EMN group had improved muscle strength (p = 0.028) and better nutritional status than the control group (p = 0.031). Both interventions were associated with a lower ICU-AW (EM vs. control: p = 0.027, OR [95% CI] = 0.066 [0.006-0.739]; EMN vs. control: p = 0.016, OR [95% CI] = 0.065 [0.007-0.607]).ConclusionEM and EMN had positive effects. There was little difference between the effects of EM and EMN, except for muscle strength improvement. Both EM and EMN may lead to a lower occurrence of ICU-AW and better functional independence than standard care. EMN might benefit nutritional status more than usual care and promote improvement in muscle strength

Feeling the Insight: Uncovering Somatic Markers of the "aha" Experience

Whether internal insight can be recognized by experiencing (somatic feeling) remains an unexplored problem. This study investigated the issue by examining potential somatic markers of the &quot;aha&quot; experience occurring at the moment of sudden insight. Participants were required to solve a set of compound remote associates (CRA) problems and were simultaneously monitored via electrodermal and cardiovascular recordings. The &quot;aha&quot;-related psychological components and somatic markers were determined by contrasting insightful solutions with non-insightful solutions. Results showed that the &quot;aha&quot; experience was an amalgam entailing positive affects and approached cognition accompanied by a greater mean skin conductance response (mSCR) amplitude and a marginally accelerated heart rate than the &quot;no-aha&quot; one. These results confirm and extend findings of the multidimensionality of the &quot;aha&quot; feeling and offer the first direct evidence of somatic markers, particularly an electrodermal signature of an &quot;aha&quot; feeling, which suggests a sudden insight could likely be experienced by individuals&#39; external soma.</p

Hydrothermal Conversion of Red Mud into Magnetic Adsorbent for Effective Adsorption of Zn(II) in Water

Red mud, a Fe-rich waste generated from the aluminum industry, was recovered as an adsorbent for wastewater treatment. The separation process of red mud from water after adsorption, including centrifugation and filtration, was complicated. This study demonstrated an alternative option to recycle red mud for preparing magnetic adsorbent via a facile hydrothermal route using ascorbic acid as reductant. Red mud is weakly magnetized and consists of andradite, muscovite, hematite, and cancrinite. After hydrothermal treatment, andradite in red mud was reductively dissolved by ascorbic acid, and transformed into magnetite and morimotoite. With increasing hydrothermal temperature, the dissolution of andradite accelerated, and the crystallite size of magnetite increased. When the hydrothermal temperature reached 200 &#176;C, the prepared adsorbent P-200 showed a desirable saturation magnetization of 4.1 Am2/kg, and could be easily magnetically separated from water after adsorption. The maximum adsorption capacity of P-200 for Zn2+ was 89.6 mg/g, which is eight-fold higher than that of the raw red mud. The adsorption of Zn2+ by P-200 fitted the Langmuir model, where cation exchange was the main adsorption mechanism. The average distribution coefficient of Zn2+ at low ppm level was 16.81 L/g for P-200, higher than those of the red mud (0.3 L/g) and the prepared P-120 (1.48 L/g) and P-270 (5.48 L/g), demonstrating that P-200 had the best adsorption capacity for Zn2+ and can be served as a practical adsorbent for real-world applications. To our knowledge, this is the first study to report the conversion of red mud into a magnetic adsorbent under mild conditions