Examples of Berezin-Toeplitz Quantization: Finite sets and Unit Interval

We present a quantization scheme of an arbitrary measure space based on overcomplete families of states and generalizing the Klauder and the Berezin-Toeplitz approaches. This scheme could reveal itself as an efficient tool for quantizing physical systems for which more traditional methods like geometric quantization are uneasy to implement. The procedure is illustrated by (mostly two-dimensional) elementary examples in which the measure space is a $N$-element set and the unit interval. Spaces of states for the $N$-element set and the unit interval are the 2-dimensional euclidean $\R^2$ and hermitian \C^2 planes

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

Deep brain stimulation (DBS) is a promising therapy for patients with refractory depression. However, key questions remain with regard to which brain target(s) should be used for stimulation, and which mechanisms underlie the therapeutic effects. Here, we investigated the effect of DBS, with low- and high-frequency stimulation (LFS, HFS), in different brain regions (ventromedial prefrontal cortex, vmPFC; cingulate cortex, Cg; nucleus accumbens (NAc) core or shell; lateral habenula, LHb; and ventral tegmental area) on a variety of depressive-like behaviors using rat models. In the naive animal study, we found that HFS of the Cg, vmPFC, NAc core and LHb reduced anxiety levels and increased motivation for food. In the chronic unpredictable stress model, there was a robust depressive-like behavioral phenotype. Moreover, vmPFC HFS, in a comparison of all stimulated targets, produced the most profound antidepressant effects with enhanced hedonia, reduced anxiety and decreased forced-swim immobility. In the following set of electrophysiological and histochemical experiments designed to unravel some of the underlying mechanisms, we found that vmPFC HFS evoked a specific modulation of the serotonergic neurons in the dorsal raphe nucleus (DRN), which have long been linked to mood. Finally, using a neuronal mapping approach by means of c-Fos expression, we found that vmPFC HFS modulated a brain circuit linked to the DRN and known to be involved in affect. In conclusion, HFS of the vmPFC produced the most potent antidepressant effects in naive rats and rats subjected to stress by mechanisms also including the DRN.postprin

De Sitter Waves and the Zero Curvature Limit

We show that a particular set of global modes for the massive de Sitter scalar field (the de Sitter waves) allows to manage the group representations and the Fourier transform in the flat (Minkowskian) limit. This is in opposition to the usual acceptance based on a previous result, suggesting the appearance of negative energy in the limit process. This method also confirms that the Euclidean vacuum, in de Sitter spacetime, has to be preferred as far as one wishes to recover ordinary QFT in the flat limit.Comment: 9 pages, latex no figure, to appear in Phys. Rev.

Adhesive Contact to a Coated Elastic Substrate

We show how the quasi-analytic method developed to solve linear elastic contacts to coated substrates (Perriot A. and Barthel E. {\em J. Mat. Res.}, {\bf 2004}, {\em 19}, 600) may be extended to adhesive contacts. Substrate inhomogeneity lifts accidental degeneracies and highlights the general structure of the adhesive contact theory. We explicit the variation of the contact variables due to substrate inhomogeneity. The relation to other approaches based on Finite Element analysis is discussed

A simple proof of Kotake-Narasimhan theorem in some classes of ultradifferentiable functions

[EN] We give a simple proof of a general theorem of Kotake-Narasimhan for elliptic operators in the setting of ultradifferentiable functions in the sense of Braun, Meise and Taylor. We follow the ideas of Komatsu. Based on an example of Metivier, we also show that the ellipticity is a necessary condition for the theorem to be true.C. Boiti and D. Jornet were partially supported by the INdAM-GNAMPA Projects 2014 and 2015. D. Jornet was partially supported by MINECO, Project MTM2013-43540-PBoiti, C.; Jornet Casanova, D. (2017). A simple proof of Kotake-Narasimhan theorem in some classes of ultradifferentiable functions. Journal of Pseudo-Differential Operators and Applications. 8(2):297-317. https://doi.org/10.1007/s11868-016-0163-yS29731782Boiti, C., Jornet, D.: The problem of iterates in some classes of ultradifferentiable functions. Oper. Theory Adv. Appl. Birkhauser Basel 245, 21–33 (2015)Boiti, C., Jornet, D.: A characterization of the wave front set defined by the iterates of an operator with constant coefficients. arXiv:1412.4954Boiti, C., Jornet, D., Juan-Huguet, J.: Wave front set with respect to the iterates of an operator with constant coefficients. Abstr. Appl. Anal. 2014, 1–17 Article ID 438716 (2014). doi: 10.1155/2014/438716Bolley, P., Camus, J., Mattera, C.: Analyticité microlocale et itérés d’operateurs hypoelliptiques. Séminaire Goulaouic-Schwartz, 1978–1979, Exp No. 13, École Polytech, PalaiseauBonet, J., Meise, R., Melikhov, S.N.: A comparison of two different ways of define classes of ultradifferentiable functions. Bull. Belg. Math. Soc. Simon Stevin 14, 425–444 (2007)Braun, R.W., Meise, R., Taylor, B.A.: Ultradifferentiable functions and Fourier analysis. Result. Math. 17, 206–237 (1990)Fernández, C., Galbis, A.: Superposition in classes of ultradifferentiable functions. Publ. Res. I Math. Sci. 42(2), 399–419 (2006)Jornet Casanova, D.: Operadores Pseudodiferenciales en Clases no Casianalíticas de Tipo Beurling. Universitat Politècnica de València (2004). doi: 10.4995/Thesis/10251/54953Juan-Huguet, J.: Iterates and hypoellipticity of partial differential operators on non-quasianalytic classes. Integr. Equ. Oper. Theory 68, 263–286 (2010)Juan-Huguet, J.: A Paley–Wiener type theorem for generalized non-quasianalytic classes. Stud. Math. 208(1), 31–46 (2012)Komatsu, H.: A characterization of real analytic functions. Proc. Jpn Acad. 36, 90–93 (1960)Komatsu, H.: On interior regularities of the solutions of principally elliptic systems of linear partial differential equations. J. Fac. Sci. Univ. Tokyo Sect. 1, 9, 141–164 (1961)Komatsu, H.: A proof of Kotaké and Narasimhan’s theorem. Proc. Jpn Acad. 38(9), 615–618 (1962)Kotake, T., Narasimhan, M.S.: Regularity theorems for fractional powers of a linear elliptic operator. Bull. Soc. Math. Fr. 90, 449–471 (1962)Kumano-Go, H.: Pseudo-Differential Operators. The MIT Press, Cambridge, London (1982)Langenbruch, M.: P-Funktionale und Randwerte zu hypoelliptischen Differentialoperatoren. Math. Ann. 239(1), 55–74 (1979)Langenbruch, M.: Fortsetzung von Randwerten zu hypoelliptischen Differentialoperatoren und partielle Differentialgleichungen. J. Reine Angew. Math. 311/312, 57–79 (1979)Langenbruch, M.: On the functional dimension of solution spaces of hypoelliptic partial differential operators. Math. Ann. 272, 217–229 (1985)Langenbruch, M.: Bases in solution sheaves of systems of partial differential equations. J. Reine Angew. Math. 373, 1–36 (1987)Lions, J.L., Magenes, E.: Problèmes aux limites non homogènes et applications, vol. 3. Dunod, Paris (1970)Métivier, G.: Propriété des itérés et ellipticité. Commun. Part. Differ. Eq. 3(9), 827–876 (1978)Nelson, E.: Analytic vectors. Ann. Math. 70, 572–615 (1959)Newberger, E., Zielezny, Z.: The growth of hypoelliptic polynomials and Gevrey classes. Proc. Am. Math. Soc. 39(3), 547–552 (1973)Oldrich, J.: Sulla regolarità delle soluzioni delle equazioni lineari ellittiche nelle classi di Beurling. (Italian) Boll. Un. Mat. Ital. (4) 2, 183–195 (1969)Petzsche, H.-J., Vogt, D.: Almost analytic extension of ultradifferentiable functions and the boundary values of holomorphic functions. Math. Ann. 267(1), 17–35 (1984

A characterization of the wave front set defined by the iterates of an operator with constant coefficients

[EN] We characterize the wave front set WF*P (u) with respect to the iterates of a linear partial differential operator with constant coefficients of a classical distribution u is an element of D '(Omega), Omega an open subset in R-n. We use recent Paley-Wiener theorems for generalized ultradifferentiable classes in the sense of Braun, Meise and Taylor. We also give several examples and applications to the regularity of operators with variable coefficients and constant strength. Finally, we construct a distribution with prescribed wave front set of this type.The authors were partially supported by FAR2011 (Universita di Ferrara), "Fondi per le necessita di base della ricerca" 2012 and 2013 (Universita di Ferrara) and the INDAM-GNAMPA Project 2014 "Equazioni Differenziali a Derivate Parziali di Evoluzione e Stocastiche" The research of the second author was partially supported by MINECO of Spain, Project MTM2013-43540-P.Boiti, C.; Jornet Casanova, D. (2017). A characterization of the wave front set defined by the iterates of an operator with constant coefficients. Revista de la Real Academia de Ciencias Exactas Físicas y Naturales Serie A Matemáticas. 111(3):891-919. https://doi.org/10.1007/s13398-016-0329-8S8919191113Albanese, A.A., Jornet, D., Oliaro, A.: Quasianalytic wave front sets for solutions of linear partial differential operators. Integr. Equ. Oper. Theory 66, 153–181 (2010)Boiti, C., Jornet, D.: The problem of iterates in some classes of ultradifferentiable functions. In: “Operator Theory: Advances and Applications”. Birkhauser, Basel. 245, 21–32 (2015)Boiti, C., Jornet, D., Juan-Huguet, J.,: Wave front set with respect to the iterates of an operator with constant coefficients. Abstr. Appl. Anal., 1–17 (2014). doi: 10.1155/2014/438716 (Article ID 438716)Bolley, P., Camus, J., Mattera, C.: Analyticité microlocale et itérés d’operateurs hypoelliptiques. In: Séminaire Goulaouic–Schwartz, 1978–79, Exp N.13. École Polytech., PalaiseauBonet, J., Fernández, C., Meise, R.: Characterization of the $$\omega$$ ω -hypoelliptic convolution operators on ultradistributions. Ann. Acad. Sci. Fenn. Math. 25, 261–284 (2000)Bonet, J., Meise, R., Melikhov, S.N.: A comparison of two different ways to define classes of ultradifferentiable functions. Bull. Belg. Math. Soc. Simon Stevin 14, 425–444 (2007)Braun, R.W., Meise, R., Taylor, B.A.: Ultradifferentiable functions and Fourier analysis. Result. Math. 17, 206–237 (1990)Fernández, C., Galbis, A., Jornet, D.: $$\omega$$ ω -hypoelliptic differential operators of constant strength. J. Math. Anal. Appl. 297, 561–576 (2004)Fernández, C., Galbis, A., Jornet, D.: Pseudodifferential operators of Beurling type and the wave front set. J. Math. Anal. Appl. 340, 1153–1170 (2008)Hörmander, L.: On interior regularity of the solutions of partial differential equations. Comm. Pure Appl. Math. XI, 197–218 (1958)Hörmander, L.: Uniqueness theorems and wave front sets for solutions of linear partial differential equations with analytic coefficients. Comm. Pure Appl. Math. 24, 671–704 (1971)Hörmander, L.: The Analysis of Linear Partial Differential Operators I. Springer, Berlin (1990)Hörmander, L.: The Analysis of Linear Partial Differential Operators II. Springer, Berlin (1983)Juan-Huguet, J.: Iterates and hypoellipticity of partial differential operators on non-quasianalytic classes. Integr. Equ. Oper. Theory 68, 263–286 (2010)Juan-Huguet, J.: A Paley–Wiener type theorem for generalized non-quasianalytic classes. Studia Math. 208(1), 31–46 (2012)Komatsu, H.: A characterization of real analytic functions. Proc. Jpn. Acad. 36, 90–93 (1960)Kotake, T., Narasimhan, M.S.: Regularity theorems for fractional powers of a linear elliptic operator. Bull. Soc. Math. France 90, 449–471 (1962)Langenbruch, M.: P-Funktionale und Randwerte zu hypoelliptischen Differentialoperatoren. Math. Ann. 239(1), 55–74 (1979)Langenbruch, M.: Fortsetzung von Randwerten zu hypoelliptischen Differentialoperatoren und partielle Differentialgleichungen. J. Reine Angew. Math. 311/312, 57–79 (1979)Langenbruch, M.: On the functional dimension of solution spaces of hypoelliptic partial differential operators. Math. Ann. 272, 217–229 (1985)Langenbruch, M.: Bases in solution sheaves of systems of partial differential equations. J. Reine Angew. Math. 373, 1–36 (1987)Métivier, G.: Propriété des itérés et ellipticité. Comm. Partial Differ. Equ. 3(9), 827–876 (1978)Newberger, E., Zielezny, Z.: The growth of hypoelliptic polynomials and Gevrey classes. Proc. Amer. Math. Soc. 39(3), 547–552 (1973)Rodino, L.: On the problem of the hypoellipticity of the linear partial differential equations. In: Buttazzo, G. (ed.) Developments in Partial Differential Equations and Applications to Mathematical Physics. Plenum Press, New York (1992)Rodino, L.: Linear partial differential operators in Gevrey spaces. World Scientific, Singapore (1993)Zanghirati, L.: Iterates of a class of hypoelliptic operators and generalized Gevrey classes. Boll. U.M.I. Suppl. 1, 177–195 (1980

New Integrable Sectors in Skyrme and 4-dimensional CP^n Model

The application of a weak integrability concept to the Skyrme and $CP^n$ models in 4 dimensions is investigated. A new integrable subsystem of the Skyrme model, allowing also for non-holomorphic solutions, is derived. This procedure can be applied to the massive Skyrme model, as well. Moreover, an example of a family of chiral Lagrangians providing exact, finite energy Skyrme-like solitons with arbitrary value of the topological charge, is given. In the case of $CP^n$ models a tower of integrable subsystems is obtained. In particular, in (2+1) dimensions a one-to-one correspondence between the standard integrable submodel and the BPS sector is proved. Additionally, it is shown that weak integrable submodels allow also for non-BPS solutions. Geometric as well as algebraic interpretations of the integrability conditions are also given.Comment: 23 page

Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of gemcitabine- or capecitabine-based chemoradiation for locally advanced pancreatic cancer

background: SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. methods: Eligibility: histologically proven LAPC less than or equal to7 cm. Following 12 weeks of induction GEMCAP chemotherapy (three cycles: GEM 1000 mg m−2 days 1, 8, 15; CAP 830 mg m−2 days 1–21 q28 days) patients with stable/responding disease, tumour less than or equal to6 cm, and WHO Performance Status 0–1 were randomised to receive one cycle GEMCAP followed by CAP (830 mg m−2 b.d. on weekdays only) or GEM (300 mg m−2 weekly) with radiation (50.4 Gy per 28 fractions). results: One-hundred fourteen patients (28 UK centres) were registered between 24 December 2009 and 25 October 2011, and 74 were randomised (CAP-RT=36; GEM-RT=38). At the time of this analysis, 105 of the 114 patients had died and the surviving 9 patients had been followed up for a median of 10.9 months (IQR: 2.9–18.7). Updated median OS was 17.6 months (95% CI: 14.6–22.7) in the CAP-CRT arm and 14.6 months (95% CI: 11.1–16.0) in the GEM-CRT arm (intention-to-treat adjusted hazard ratio (HR): 0.68 (95% CI: 0.38–1.21, P=0.185)); median progression-free survival (PFS) was 12.0 months (95% CI: 10.0–15.2) in the CAP-CRT arm and 10.4 months (95% CI: 8.8–12.7) in the GEM-CRT arm (intention-to-treat adjusted HR: 0.60 (95% CI: 0.32–1.14, P=0.120)). In baseline multivariable model, age greater than or equal to65 years, better performance status, CA19.9<613 IU l−1, and shorter tumour diameter predicted improved OS. CAP-CRT, age greater than or equal to65 years, better performance status, CA19.9 <46 IU ml−1 predicted improved OS and PFS in the pre-radiotherapy model. Nine-month PFS was highly predictive of OS. conclusions: CAP-CRT remains the superior regimen. SCALOP showed that patients with CA19.9 <46 IU ml−1 after induction chemotherapy are more likely to benefit from CRT

A comprehensive categorical and bibliometric analysis of published research articles on pediatric pain from 1975 to 2010

The field of pediatric pain research began in the mid-1970s and has undergone significant growth and development in recent years as evidenced by the variety of books, conferences, and journals on the topic and also the number of disciplines engaged in work in this area. Using categorical and bibliometric meta-trend analysis, this study offers a synthesis of research on pediatric pain published between 1975 and 2010 in peer-reviewed journals. Abstracts from 4256 articles, retrieved from Web of Science, were coded across 4 categories: article type, article topic, type and age of participants, and pain stimulus. The affiliation of the first author and number of citations were also gathered. The results suggest a significant increase in the number of publications over the time period investigated, with 96% of the included articles published since 1990 and most research being multiauthored publications in pain-focused journals. First authors were most often from the United States and affiliated with a medical department. Most studies were original research articles; the most frequent topics were pain characterization (39.86%), pain intervention (37.49%), and pain assessment (25.00%). Clinical samples were most frequent, with participants most often characterized as children (6-12 years) or adolescents (13-18 years) experiencing chronic or acute pain. The findings provide a comprehensive overview of contributions in the field of pediatric pain research over 35 years and offers recommendations for future research in the area. &copy; 2015 International Association for the Study of Pain