Circumstellar chemistry

The study of the outer envelopes of cool evolved stars has become an active area of research. The physical properties of CS envelopes are presented. Observations of many wavelengths bands are relevant. A summary of observations and a discussion of theoretical considerations concerning the chemistry are summarized. Recent theoretical considerations show that the thermal equilibrium model is of limited use for understanding the chemistry of the outer CS envelopes. The theoretical modeling of the chemistry of CS envelopes provides a quantitive test of chemical concepts which have a broader interest than the envelopes themselves

Simultaneous observations of active galactic nuclei with IUE

The IUE observations of four active nuclei were coordinated with radio, infrared, and X-ray measurements to obtain simultaneous determinations of their continuous spectra. The results for the BL Lac objects 0735+178 and I Zw 187 indicate sufficient UV and X-ray fluxes to ionize any gas. Comparison of the X-ray measurements with the extrapolated optical UV continuum show a definite X-ray excess for I Zw 187 but none for the other BL Lac object

The Shapes of AGB Envelopes as Probes of Binary Companions

We describe how the large scale geometry of the circumstellar envelopes of asymptotic giant branch stars can be used to probe the presence of unseen stellar companions. A nearby companion modifies the mass loss by gravitationally focusing the wind towards the orbital plane, and thereby determines the shape of the envelope at large distances from the star. Using available simulations, we develop a prescription for the observed shapes of envelopes in terms of the binary parameters, envelope orientation, and type of observation. The prescription provides a tool for the analysis of envelope images at optical, infrared, and millimetre wavelengths, which can be used to constrain the presence of companions in well observed cases. We illustrate this approach by examining the possible role of binary companions in triggering the onset of axi-symmetry in planetary nebula formation. If interaction with the primary leads to axi-symmetry, the spherical halos widely seen around newly formed nebulae set limits on the companion mass. Only low mass objects may orbit close to the primary without observable shaping effects: they remain invisible until the interaction causes a sudden change in the mass loss geometry.Comment: 11 pages, 7 figures, to appear in MNRA

An automatic data system for vibration modal tuning and evaluation

A digitally based automatic modal tuning and analysis system developed to provide an operational capability beginning at 0.1 hertz is described. The elements of the system, which provides unique control features, maximum operator visibility, and rapid data reduction and documentation, are briefly described; and the operational flow is discussed to illustrate the full range of capabilities and the flexibility of application. The successful application of the system to a modal survey of the Skylab payload is described. Information about the Skylab test article, coincident-quadrature analysis of modal response data, orthogonality, and damping calculations is included in the appendixes. Recommendations for future application of the system are also made

Exploring the role of water in molecular recognition: predicting protein ligandability using a combinatorial search of surface hydration sites

The interaction between any two biological molecules must compete with their interaction with water molecules. This makes water the most important molecule in medicine, as it controls the interactions of every therapeutic with its target. A small molecule binding to a protein is able to recognize a unique binding site on a protein by displacing bound water molecules from specific hydration sites. Quantifying the interactions of these water molecules allows us to estimate the potential of the protein to bind a small molecule. This is referred to as ligandability. In the study, we describe a method to predict ligandability by performing a search of all possible combinations of hydration sites on protein surfaces. We predict ligandability as the summed binding free energy for each of the constituent hydration sites, computed using inhomogeneous fluid solvation theory. We compared the predicted ligandability with the maximum observed binding affinity for 20 proteins in the human bromodomain family. Based on this comparison, it was determined that effective inhibitors have been developed for the majority of bromodomains, in the range from 10 to 100 nM. However, we predict that more potent inhibitors can be developed for the bromodomains BPTF and BRD7 with relative ease, but that further efforts to develop inhibitors for ATAD2 will be extremely challenging. We have also made predictions for the 14 bromodomains with no reported small molecule K d values by isothermal titration calorimetry. The calculations predict that PBRM1(1) will be a challenging target, while others such as TAF1L(2), PBRM1(4) and TAF1(2), should be highly ligandable. As an outcome of this work, we assembled a database of experimental maximal K d that can serve as a community resource assisting medicinal chemistry efforts focused on BRDs. Effective prediction of ligandability would be a very useful tool in the drug discovery process.Work in the DJH laboratory is supported by the Medical Research Council under grant ML/L007266/1. All calculations were performed using the Darwin Supercomputer of the University of Cambridge High Performance Computing Service (http://www.hpc.cam.ac.uk/) provided by Dell Inc. using Strategic Research Infrastructure Funding from the Higher Education Funding Council for England, and were funded by the EPSRC under grants EP/F032773/1 and EP/J017639/1

High Resolution CO and H2 Molecular Line Imaging of a Cometary Globule in the Helix Nebula

We report high resolution imaging of a prominent cometary globule in the Helix nebula in the CO J=1-0 (2.6 mm) and H2 v=1-0 S(1) (2.12 micron) lines. The observations confirm that globules consist of dense condensations of molecular gas embedded in the ionized nebula. The head of the globule is seen as a peak in the CO emission with an extremely narrow line width (0.5 km/s) and is outlined by a limb-brightened surface of H2 emission facing the central star and lying within the photo-ionized halo. The emission from both molecular species extends into the tail region. The presence of this extended molecular emission provides new constraints on the structure of the tails, and on the origin and evolution of the globules.Comment: 12 pages, 3 figures. To appear in The Astrophysical Journal Letter

Solid state television camera system Patent

Solid state television camera system consisting of monolithic semiconductor mosaic sensor and molecular digital readout system

EFFECTIVENESS OF SQUIRREL FENCING FOR PROTECTING PECAN GROVES

During 1994, we tested the hypothesis that an energized, high-tensile wire fence prevents fox squirrels (Sciurus niger) from crossing into a pecan (Carya illinoensis) grove. When the fence was energized, we recorded fewer (P = 0.03) trips across the fence by squirrels (n - 19) and fewer (P \u3c 0.001) telemetry fix-points in the pecan grove. Effective squirrel fencing may offer wildlife managers an alternative method of damage prevention. Ecological ramifications to target and non-target species are discussed

VLA Observations of H I in the Helix Nebula (NGC 7293)

We report the detection of 21-cm line emission from H I in the planetary nebula NGC 7293 (the Helix). The observations, made with the Very Large Array, show the presence of a ring of atomic hydrogen that is associated with the outer portion of the ionized nebula. This ring is most probably gas ejected in the AGB phase that has been subsequently photodissociated by radiation from the central star. The H I emission spreads over about 50 km/s in radial velocity. The mass in H I is approximately 0.07 solar masses, about three times larger than the mass in molecular hydrogen and comparable with the mass in ionized hydrogen.Comment: 19 pages, 9 figure

Advanced stratified charge rotary aircraft engine design study

A technology base of new developments which offered potential benefits to a general aviation engine was compiled and ranked. Using design approaches selected from the ranked list, conceptual design studies were performed of an advanced and a highly advanced engine sized to provide 186/250 shaft Kw/HP under cruise conditions at 7620/25,000 m/ft altitude. These are turbocharged, direct-injected stratified charge engines intended for commercial introduction in the early 1990's. The engine descriptive data includes tables, curves, and drawings depicting configuration, performance, weights and sizes, heat rejection, ignition and fuel injection system descriptions, maintenance requirements, and scaling data for varying power. An engine-airframe integration study of the resulting engines in advanced airframes was performed on a comparative basis with current production type engines. The results show airplane performance, costs, noise & installation factors. The rotary-engined airplanes display substantial improvements over the baseline, including 30 to 35% lower fuel usage