Prognostička vrijednost ekspresije CD44 i neovaskularizacije određene endoglinom (CD05) u bolesnika s glioblasto-mom

Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Clinically useful molecular markers that help predict response to therapy and prognosis are still rare. The research was conducted in 55 patients with GBM, 26 (47.3%) women and 29 (52.7%) men, mean age 62.58 years. On immunohistochemical analysis, primary antibody to CD44 (dilution 1:50) and primary antibody to endoglin (CD105) (dilution 1:250) were used to evaluate neovascularization. Statisti-cal analysis showed negative correlation between CD44 and survival (p=0.023) (higher expression of CD44 was correlated with shorter survival), but there was no correlation between neovascularization de-termined by CD105 in GBM and patient survival. Thus, significant individual predictors of longer survival were lower expression of CD44 (p=0.004), higher Karnofsky score (p=0.045), and female gender (p=0.017). The results obtained suggested the possible role of CD44 in the progression and tumor neovas-cularization of GBM.Glioblastom multiforme (GBM) je najčešći i najagresivniji maligni primarni tumor mozga u ljudi. Postoje tek rijetki molekularni biljezi koji su klinički korisni te pomažu u predviđanju odgovora na terapiju i u prognozi bolesti. Istraži-vanje je provedeno kod 55 bolesnika s GBM, 26 (47,3%) žena i 29 (52,7%) muškaraca, prosječne dobi od 62,58 godina. U imunohistokemijskoj analizi je za procjenu neovaskularizacije korišteno primarno antitijelo prema CD44 (razrjeđenje 1:50) i primarno antitijelo prema endoglinu (CD105) (razrjeđenje 1:250). Statistička analiza je pokazala negativnu korelaciju između CD44 i preživljenja (p=0,023) (veća ekspresija CD44 je korelirala s kraćim preživlje-njem), ali nije bilo korelacije između neovaskularizacije (određene putem CD105) kod GBM i preživljenja ovih bole-snika. Tako su značajni pojedinačni prediktori dužeg preživljenja bili niža ekspresija CD44 (p=0,004), veći Karnof-skyjev zbir (p=0,045) i ženski spol (p=0,017). Dobiveni rezultati ukazuju na moguću ulogu CD44 u progresiji i tumor-skoj neovaskularizaciji kod GBM