Indonesian earthquake: Earthquake risk from co-seismic stress.

Following the massive loss of life caused by the Sumatra-Andaman earthquake in Indonesia and its tsunami, the possibility of a triggered earthquake on the contiguous Sunda trench subduction zone is a real concern. We have calculated the distributions of co-seismic stress on this zone, as well as on the neighbouring, vertical strike-slip Sumatra fault, and find an increase in stress on both structures that significantly boosts the already considerable earthquake hazard posed by them. In particular, the increased potential for a large subduction-zone event in this region, with the concomitant risk of another tsunami, makes the need for a tsunami warning system in the Indian Ocean all the more urgent.John McCloskey, Suleyman S.Nalbant, Sandy Steac

Predictive response-relevant clustering of expression data provides insights into disease processes

This article describes and illustrates a novel method of microarray data analysis that couples model-based clustering and binary classification to form clusters of ;response-relevant' genes; that is, genes that are informative when discriminating between the different values of the response. Predictions are subsequently made using an appropriate statistical summary of each gene cluster, which we call the ;meta-covariate' representation of the cluster, in a probit regression model. We first illustrate this method by analysing a leukaemia expression dataset, before focusing closely on the meta-covariate analysis of a renal gene expression dataset in a rat model of salt-sensitive hypertension. We explore the biological insights provided by our analysis of these data. In particular, we identify a highly influential cluster of 13 genes-including three transcription factors (Arntl, Bhlhe41 and Npas2)-that is implicated as being protective against hypertension in response to increased dietary sodium. Functional and canonical pathway analysis of this cluster using Ingenuity Pathway Analysis implicated transcriptional activation and circadian rhythm signalling, respectively. Although we illustrate our method using only expression data, the method is applicable to any high-dimensional datasets

Probabilities from Entanglement, Born's Rule from Envariance

I show how probabilities arise in quantum physics by exploring implications of {\it environment - assisted invariance} or {\it envariance}, a recently discovered symmetry exhibited by entangled quantum systems. Envariance of perfectly entangled ``Bell-like'' states can be used to rigorously justify complete ignorance of the observer about the outcome of any measurement on either of the members of the entangled pair. For more general states, envariance leads to Born's rule, $p_k \propto |\psi_k|^2$ for the outcomes associated with Schmidt states. Probabilities derived in this manner are an objective reflection of the underlying state of the system -- they represent experimentally verifiable symmetries, and not just a subjective ``state of knowledge'' of the observer. Envariance - based approach is compared with and found superior to pre-quantum definitions of probability including the {\it standard definition} based on the `principle of indifference' due to Laplace, and the {\it relative frequency approach} advocated by von Mises. Implications of envariance for the interpretation of quantum theory go beyond the derivation of Born's rule: Envariance is enough to establish dynamical independence of preferred branches of the evolving state vector of the composite system, and, thus, to arrive at the {\it environment - induced superselection (einselection) of pointer states}, that was usually derived by an appeal to decoherence. Envariant origin of Born's rule for probabilities sheds a new light on the relation between ignorance (and hence, information) and the nature of quantum states.Comment: Figure and an appendix (Born's rule for continuous spectra) added. Presentation improved. (Comments still welcome...

Decoherence, einselection, and the quantum origins of the classical

Decoherence is caused by the interaction with the environment. Environment monitors certain observables of the system, destroying interference between the pointer states corresponding to their eigenvalues. This leads to environment-induced superselection or einselection, a quantum process associated with selective loss of information. Einselected pointer states are stable. They can retain correlations with the rest of the Universe in spite of the environment. Einselection enforces classicality by imposing an effective ban on the vast majority of the Hilbert space, eliminating especially the flagrantly non-local "Schr\"odinger cat" states. Classical structure of phase space emerges from the quantum Hilbert space in the appropriate macroscopic limit: Combination of einselection with dynamics leads to the idealizations of a point and of a classical trajectory. In measurements, einselection replaces quantum entanglement between the apparatus and the measured system with the classical correlation.Comment: Final version of the review, with brutally compressed figures. Apart from the changes introduced in the editorial process the text is identical with that in the Rev. Mod. Phys. July issue. Also available from http://www.vjquantuminfo.or

Kinematic behavior of southern Alaska constrained by westward decreasing postglacial slip rates on the Denali Fault, Alaska

Long-term slip rates for the Denali Fault in southern Alaska are derived using ^(10)Be cosmogenic radionuclide (CRN) dating of offset glacial moraines at two sites. Correction of ^(10)Be CRN model ages for the effect of snow shielding uses historical, regional snow cover data scaled to the site altitudes. To integrate the time variation of snow cover, we included the relative changes in effective wetness over the last 11 ka, derived from lake-level records and δ^(18)O variations from Alaskan lakes. The moraine CRN model ages are normally distributed around an average of 12.1 ± 1.0 ka (n = 22, ± 1σ). The slip rate decreases westward from ~13 mm/a at 144°49′W to about 7 mm/a at 149°26′W. The data are consistent with a kinematic model in which southern Alaska translates northwestward at a rate of ~14 mm/a relative to a stable northern Alaska with no rotation. This suggests progressive slip partitioning between the Denali Fault and the active fold and thrust belt at the northern front of the Alaska range, with convergence rates increasing westward from ~4 mm/a to 11 mm/a between ~149°W and 145°W. As the two moraines sampled for this study were emplaced synchronously, our suggestion of a westward decrease in the slip rate of the Denali Fault relies largely upon the measured offsets at both sites, regardless of any potential systematic uncertainty in the CRN model ages

The serotonin receptor 3E variant is a risk factor for female IBS-D

Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT3 receptor family. 5-HT3Rs are encoded by HTR3 genes and control GI function, and peristalsis and secretion, in particular. Moreover, 5-HT3R antagonists are beneficial in the treatment of diarrhea predominant IBS (IBS-D). We previously reported on functionally relevant SNPs in HTR3A c.-42C > T (rs1062613), HTR3C p.N163K (rs6766410), and HTR3E c.*76G > A (rs56109847 = rs62625044) being associated with IBS-D, and the HTR3B variant p.Y129S (rs1176744) was also described within the context of IBS. We performed a multi-center study to validate previous results and provide further evidence for the relevance of HTR3 genes in IBS pathogenesis. Therefore, genotype data of 2682 IBS patients and 9650 controls from 14 cohorts (Chile, Germany (2), Greece, Ireland, Spain, Sweden (2), the UK (3), and the USA (3)) were taken into account. Subsequent meta-analysis confirmed HTR3E c.*76G > A (rs56109847 = rs62625044) to be associated with female IBS-D (OR = 1.58; 95% CI (1.18, 2.12)). Complementary expression studies of four GI regions (jejunum, ileum, colon, sigmoid colon) of 66 IBS patients and 42 controls revealed only HTR3E to be robustly expressed. On top, HTR3E transcript levels were significantly reduced in the sigma of IBS patients (p = 0.0187); more specifically, in those diagnosed with IBS-D (p = 0.0145). In conclusion, meta-analysis confirmed rs56109847 = rs62625044 as a risk factor for female IBS-D. Expression analysis revealed reduced HTR3E levels in the sigmoid colon of IBS-D patients, which underlines the relevance of HTR3E in the pathogenesis of IBS-D

Homogenization of nonlinearly elastic materials, microscopic bifurcation and macroscopic loss of rank-one convexity

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46162/1/205_2004_Article_BF00380256.pd

Twenty-three unsolved problems in hydrology (UPH) – a community perspective

This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through on-line media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focussed on process-based understanding of hydrological variability and causality at all space and time scales. Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come