Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study.

To validate associations between MRI features and gene expression profiles in retinoblastoma, thereby evaluating the repeatability of radiogenomics in retinoblastoma. In this retrospective multicenter cohort study, retinoblastoma patients with gene expression data and MRI were included. MRI features (scored blinded for clinical data) and matched genome-wide gene expression data were used to perform radiogenomic analysis. Expression data from each center were first separately processed and analyzed. The end product normalized expression values from different sites were subsequently merged by their Z-score to permit cross-sites validation analysis. The MRI features were non-parametrically correlated with expression of photoreceptorness (radiogenomic analysis), a gene expression signature informing on disease progression. Outcomes were compared to outcomes in a previous described cohort. Thirty-six retinoblastoma patients were included, 15 were female (42%), and mean age was 24 (SD 18) months. Similar to the prior evaluation, this validation study showed that low photoreceptorness gene expression was associated with advanced stage imaging features. Validated imaging features associated with low photoreceptorness were multifocality, a tumor encompassing the entire retina or entire globe, and a diffuse growth pattern (all p < 0.05). There were a number of radiogenomic associations that were also not validated. A part of the radiogenomic associations could not be validated, underlining the importance of validation studies. Nevertheless, cross-center validation of imaging features associated with photoreceptorness gene expression highlighted the capability radiogenomics to non-invasively inform on molecular subtypes in retinoblastoma. Radiogenomics may serve as a surrogate for molecular subtyping based on histopathology material in an era of eye-sparing retinoblastoma treatment strategies. • Since retinoblastoma is increasingly treated using eye-sparing methods, MRI features informing on molecular subtypes that do not rely on histopathology material are important. • A part of the associations between retinoblastoma MRI features and gene expression profiles (radiogenomics) were validated. • Radiogenomics could be a non-invasive technique providing information on the molecular make-up of retinoblastoma

Implicit response-irrelevant number information triggers the SNARC effect : Evidence using a neural overlap paradigm

Peer reviewedPostprin

Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy

We review HB stars in a broad astrophysical context, including both variable and non-variable stars. A reassessment of the Oosterhoff dichotomy is presented, which provides unprecedented detail regarding its origin and systematics. We show that the Oosterhoff dichotomy and the distribution of globular clusters (GCs) in the HB morphology-metallicity plane both exclude, with high statistical significance, the possibility that the Galactic halo may have formed from the accretion of dwarf galaxies resembling present-day Milky Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the second-parameter problem is presented. A technique is proposed to estimate the HB types of extragalactic GCs on the basis of integrated far-UV photometry. The relationship between the absolute V magnitude of the HB at the RR Lyrae level and metallicity, as obtained on the basis of trigonometric parallax measurements for the star RR Lyrae, is also revisited, giving a distance modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are studied. Finally, the conductive opacities used in evolutionary calculations of low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and Space Scienc

Lower Hybrid Heating and Current Drive on the Alcator C-Mod Tokamak

On the Alcator C-Mod tokamak, lower hybrid current drive (LHCD) is being used to modify the current profile with the aim of obtaining advanced tokamak (AT) performance in plasmas with parameters similar to those that would be required on ITER. To date, power levels in excess of 1 MW at a frequency of 4.6 GHz have been coupled into a variety of plasmas. Experiments have established that LHCD on C-Mod behaves globally as predicted by theory. Bulk current drive efficiencies, n20IlhR/Plh ~ 0.25, inferred from magnetics and MSE are in line with theory. Quantitative comparisons between local measurements, MSE, ECE and hard x-ray bremsstrahlung, and theory/simulation using the GENRAY, TORIC-LH CQL3D and TSC-LSC codes have been performed. These comparisons have demonstrated the off-axis localization of the current drive, its magnitude and location dependence on the launched n|| spectrum, and the use of LHCD during the current ramp to save volt-seconds and delay the peaking of the current profile. Broadening of the x-ray emission profile during ICRF heating indicates that the current drive location can be controlled by the electron temperature, as expected. In addition, an alteration in the plasma toroidal rotation profile during LHCD has been observed with a significant rotation in the counter current direction. Notably, the rotation is accompanied by peaking of the density and temperature profiles on a current diffusion time scale inside of the half radius where the LH absorption is taking place