Design and hardware evaluation of the optical-link system for the ATLAS Liquid Argon Calorimeter Phase-II Upgrade

An optical link system is being developed for the ATLAS Liquid Argon Calorimeter Phase-II upgrade. The optical link system is responsible for transmit the data of over 182 thousand detector channels from 1524 Front-End Boards (FEBs) through 26 optical fibers per FEB over 150 meters to the counting room and brings clocks, bunch crossing reset signals and slow control/monitoring signals back to the FEBs. The optical link system is based on the Low-Power GigaBit Transceivers (lpGBTs) and the Versatile optical Transceiver (VTRx+) modules, which both are being developed for the High-Luminosity LHC upgrade. An evaluation board is designed and the major functions of the optical link system are being evaluated. The design of the optical link system and the evaluation of major functions are presented in the paper.Comment: 12 pages, 8 figure

Optical Data Transmission ASICs for the High-Luminosity LHC (HL-LHC) Experiments

We present the design and test results of two optical data transmission ASICs for the High-Luminosity LHC (HL-LHC) experiments. These ASICs include a two-channel serializer (LOCs2) and a single-channel Vertical Cavity Surface Emitting Laser (VCSEL) driver (LOCld1V2). Both ASICs are fabricated in a commercial 0.25-um Silicon-on-Sapphire (SoS) CMOS technology and operate at a data rate up to 8 Gbps per channel. The power consumption of LOCs2 and LOCld1V2 are 1.25 W and 0.27 W at 8-Gbps data rate, respectively. LOCld1V2 has been verified meeting the radiation-tolerance requirements for HL-LHC experiments.Comment: 9 pages, 12 figure

Permeability evolution of fractured coal subject to confining stress and true triaxial stress loading: experiment and mathematical model

The accurate elucidation and prediction of coal permeability evolution under stress loading conditions are crucial for coalbed methane production. In this study, flow experiments were conducted on six cylindrical coal samples and four cubic coal samples under both confining and true triaxial stress loading conditions, respectively. The structure and characteristic parameters of the fractures inside each coal sample were obtained using the computed tomography scanning system and image processing technologies. The coal permeability under both types of loading processes was calculated through the transient pulse method. A mathematical model was developed to assess the evolution of coal permeability under true triaxial loading based on the current true triaxial permeability model and fractal theory. The results revealed that during the confining pressure loading, the coal permeability decreased exponentially with effective stress and was effectively described using the SD model. Additionally, the coal permeability initially rapidly decreased, followed by a gradual decrease, and eventually stabilized at a constant value. Particularly, during the first three loading steps, the fracture aperture and corresponding permeability of the six cylindrical coal samples decreased by ∼51.79%–57.83% and ∼38.06%–42.12%, respectively. However, during the final three loading steps, the fracture aperture and corresponding permeability of the six coal samples decreased by ∼18.26%–23.08% and ∼22.15%–26.93%, respectively. Moreover, owing to the various crossing angles of complex fracture networks with each principal stress, the effect of each principal stress on the coal permeability evolution was highly anisotropic during triaxial stress loading. Particularly, the permeability of the ST1 sample decreased by 43.08%, 14.84%, and 42.08% during the loading of each principal stress. Similarly, the permeability of the ST2 sample decreased by ∼65.74%, 14.29%, and 19.97%. The permeability reductions for the ST3 sample were ∼34.03%, 55.85%, and 10.12%, while those for the ST4 sample were ∼35.97%, 46.51%, and 17.52%. The SD model failed to describe these anisotropic effects. Compared with the SD model, the improved model, based on the current true triaxial permeability model and fractal theory, effectively described the anisotropic effect of each principal stress on the permeability of coal samples with complex fracture networks under triaxial stress conditions

Nerve growth factor alleviates arsenic-induced testicular injury by enhancing the function of Sertoli cells

Sertoli cells (SCs) maintain testicular homeostasis and promote spermatogenesis by forming the blood-testis barrier (BTB) and secreting growth factors. The pro-proliferative and anti-apoptotic effects of nerve growth factor (NGF) on SCs have been proved previously. It is still unclear whether the damage effect of arsenic on testis is related to the inhibition of NGF expression, and whether NGF can mitigate arsenic-induced testicular damage by decreasing the damage of SCs induced by arsenic. Here, the lower expression of NGF in testes of arsenic exposed mice (freely drinking water containing 15 mg/l of NaAsO2) was observed through detection of Western blot and Real-time PCR. Subsequently, hematoxylin and eosin (HE) staining, Evans blue staining and transmission electron microscopy were used to evaluate the pathology, BTB permeability and tight junction integrity in testes of control mice, arsenic exposed mice (freely drinking water containing 15 mg/l of NaAsO2) and arsenic + NGF treated mice (freely drinking water containing 15 mg/l of NaAsO2 + intraperitoneal injection with 30 μg/kg of NGF), respectively. Evidently, spermatogenic tubule epithelial cells in testis of arsenic exposed mice were disordered and the number of cell layers was reduced, accompanied by increased permeability and damaged integrity of the tight junction in BTB, but these changes were less obvious in testes of mice treated with arsenic + NGF. In addition, the sperm count, motility and malformation rate of mice treated with arsenic + NGF were also improved. On the basis of the above experiments, the viability and apoptosis of primary cultured SCs treated with arsenic (10 μM NaAsO2) or arsenic + NGF (10 μM NaAsO2 + 100 ng/mL NGF) were detected by Cell counting kit-8 (CCK8) and transferase-mediated DUTP-biotin nick end labeling (TUNEL) staining, respectively. It is found that NGF ameliorated the decline of growth activity and the increase of apoptosis in arsenic-induced SCs. This remarkable biological effect that NGF inhibited the increase of Bax expression and the decrease of Bcl-2 expression in arsenic-induced SCs was also determined by western blot and Real-time PCR. Moreover, the decrease in transmembrane resistance (TEER) and the expression of tight junction proteins ZO-1 and occludin was mitigated in SCs induced by arsenic due to NGF treatment. In conclusion, the above results confirmed that NGF could ameliorate the injury effects of arsenic on testis, which might be related to the function of NGF to inhibit arsenic-induced SCs injury

LncRNA RP11-86H7.1 promotes airway inflammation induced by TRAPM2.5 by acting as a ceRNA of miRNA-9-5p to regulate NFKB1 in HBECS

Abstract Traffic-related air pollution particulate matter 2.5 (TRAPM2.5), is involved in chronic obstructive pulmonary disease (COPD), which is characterized by airway inflammation. Specifically, these harmful particles or gases can increase chronic airway inflammation. Some recent studies have shown that lncRNAs are closely related to COPD and participate in the regulation of airway inflammation. However, the precise mechanisms remain unknown. In the present study, we investigated the effect of TRAPM2.5 on airway inflammation in human bronchial epithelial cells (HBECs) and the underlying mechanisms mediated by a lncRNA. After exposure to TRAPM2.5, the novel lncRNA RP11-86H7.1 was markedly upregulated in HBECs. Functional assays indicated that the lncRNA RP11-86H7.1 was required for the TRAPM2.5-induced expression of inflammatory factors in HBECs. A mechanistic study demonstrated that lncRNA RP11-86H7.1 might participate in TRAPM2.5-induced inflammatory responses by activating the NF-κB signaling pathway. Moreover, the lncRNA RP11-86H7.1 can promote the inflammatory response by acting as a competing endogenous RNA of miR-9-5p, reversing the inhibitory effect of its target gene NFKB1, and sustaining NF-κB activation. In summary, our study elucidates the pro-inflammatory roles of the lncRNA RP11-86H7.1–miR-9-5p–NFKB1 regulatory network in airway inflammation induced by TRAPM2.5 and indicates that the components of this network might serve as novel diagnostic biomarkers and potential therapeutic targets

A facile way to fabricate double-shell pomegranate-like porous carbon microspheres for high-performance Li-ion batteries

We report for the first time a facile preparation of double-shell pomegranate-like porous carbon microspheres (PCMs) by a modified templating technique. The microsized PCMs are encapsulated within integrated carbon coating layers and composed of interconnected nanosized hollow carbon spheres, giving rise to a special double-shell structure. Calcium carbonate (CaCO 3 ) is employed as the primary sacrificial template and acetylene as the carbon precursor via chemical vapor deposition (CVD). The PCMs exhibit an initial coulombic efficiency of 91% and a reversible capacity of 650 mA h g -1 at a current density of 200 mA g -1 after 500 cycles. Moreover, PCMs show excellent rate capability with capacities of 580 and 520 mA h g -1 at current densities of 1000 and 2000 mA g -1 , respectively. The outstanding electrochemical properties of PCMs are originated from their unique structure. The inner interconnected porous carbon framework encapsulated by a self-supporting outer carbon coating shell provides more lithium ion storage sites, high electronic conductivity and fast ion diffusion. Most importantly, different from the previous studies, the introduction of the carbon coating layers on the outer surface of the whole microsphere can effectively strengthen the mechanical properties and prevent the electrolyte ingress, limiting the formation of extra solid-electrolyte interface films

Comparison of the clinical efficacy between single-agent and dual-agent concurrent chemoradiotherapy in the treatment of unresectable esophageal squamous cell carcinoma: a multicenter retrospective analysis

Abstract Background Some Chinese patients with esophageal squamous cell carcinomaare often treated with single-agent concurrent chemoradiotherapy. However, no results have been reported from randomized controlled clinical trials comparing single-agent with double-agent concurrent chemoradiotherapy. It therefore remains unclear whether these regimens are equally clinically effective. In this study, we retrospectively analyzed and compared the therapeutic effects of single-agent and double-agent concurrent chemoradiotherapy in patients with unresectable esophageal squamous cell carcinoma. Methods This study enrolled 168 patients who received definitive concurrent chemoradiotherapy for locally advanced unresectable esophageal squamous carcinoma at 10 hospitals between 2010 and 2015. We evaluated survival time and toxicity. The Kaplan-Meier method was used to estimate survival data. The log-rank test was used in univariate analysis A Cox proportional hazards regression model was used to conduct a multivariate analysis of the effects of prognostic factors on survival. Results In this study, 100 (59.5%) and 68 patients (40.5%) received single-agent and dual-agent combination chemoradiotherapy, respectively. The estimate 5-year progression-free survival (PFS) rate and overall survival (OS) rate of dual-agent therapy was higher than that of single-agent therapy (52.5% and 40.9%, 78.2% and 60.7%, respectively), but there were no significant differences (P = 0.367 and 0.161, respectively). Multivariate analysis showed that sex, age,and radiotherapy dose had no significant effects on OS or PFS. Only disease stage was associated with OS and PFS in the multivariable analysis (P = 0.006 and 0.003, respectively). In dual-agent group, the incidence of acute toxicity and the incidence of 3 and4 grade toxicity were higher than single-agent group. Conclusion The 5-year PFS and OS rates of dual-agent therapy were higher than those of single-agent concurrent chemoradiotherapy for patients with unresectable esophageal squamous cell carcinoma; however, there were no significant differences in univariate analysis and multivariable analysis. Single-agent concurrent chemotherapy had less toxicity than a double-drug regimen. Therefore, we suggest that single therapis not inferior to dual therapy y. In the future, we aim to confirm our hypothesis through a prospective randomized study