Multiple parietal reach regions in humans: cortical representations for visual and proprioceptive feedback during on-line reaching

Reaching toward a visual target involves at least two sources of information. One is the visual feedback from the hand as it approaches the target. Another is proprioception from the moving limb, which informs the brain of the location of the hand relative to the target even when the hand is not visible. Where these two sources of information are represented in the human brain is unknown. In the present study, we investigated the cortical representations for reaching with or without visual feedback from the moving hand, using functional magnetic resonance imaging. To identify reach-dominant areas, we compared reaching with saccades. Our results show that a reach-dominant region in the anterior precuneus (aPCu), extending into medial intraparietal sulcus, is equally active in visual and nonvisual reaching. A second region, at the superior end of the parieto-occipital sulcus (sPOS), is more active for visual than for nonvisual reaching. These results suggest that aPCu is a sensorimotor area whose sensory input is primarily proprioceptive, while sPOS is a visuomotor area that receives visual feedback during reaching. In addition to the precuneus, medial, anterior intraparietal, and superior parietal cortex were also activated during both visual and nonvisual reaching, with more anterior areas responding to hand movements only and more posterior areas responding to both hand and eye movements. Our results suggest that cortical networks for reaching are differentially activated depending on the sensory conditions during reaching. This indicates the involvement of multiple parietal reach regions in humans, rather than a single homogenous parietal reach region

Preliminary design of the Visible Spectro-Polarimeter for the Advanced Technology Solar Telescope

The Visible Spectro-Polarimeter (ViSP) is one of the first light instruments for the Advanced Technology Solar Telescope (ATST). It is an echelle spectrograph designed to measure three different regions of the solar spectrum in three separate focal planes simultaneously between 380 and 900 nm. It will use the polarimetric capabilities of the ATST to measure the full Stokes parameters across the line profiles. By measuring the polarization in magnetically sensitive spectral lines the magnetic field vector as a function of height in the solar atmosphere can be obtained, along with the associated variation of the thermodynamic properties. The ViSP will have a spatial resolution of 0.04 arcsec over a 2 arcmin field of view (at 600 nm). The minimum spectral resolving power for all the focal planes is 180,000. The spectrograph supports up to 4 diffraction gratings and is fully automated to allow for rapid reconfiguration.Comment: 8 pages, 5 figures, proceedings of SPIE Astronomical Telescopes + Instrumentation 2012 Conference 8446 (1-5 July 2012

THz generation using a reflective stair-step echelon

We present a novel method for THz generation in lithium niobate using a reflective stair-step echelon structure. The echelon produces a discretely tilted pulse front with less angular dispersion compared to a high groove-density grating. The THz output was characterized using both a 1-lens and 3-lens imaging system to set the tilt angle at room and cryogenic temperatures. Using broadband 800 nm pulses with a pulse energy of 0.95 mJ and a pulse duration of 70 fs (24 nm FWHM bandwidth, 39 fs transform limited width), we produced THz pulses with field strengths as high as 500 kV/cm and pulse energies as high as 3.1 $\mu$J. The highest conversion efficiency we obtained was 0.33%. In addition, we find that the echelon is easily implemented into an experimental setup for quick alignment and optimization.Comment: 19 pages, 4 figure

Characterization of Laser-Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy.

Background and objectivesPort wine stain (PWS) is a congenital vascular malformation of the human skin. Laser is the treatment of choice for PWS. Laser-resistant PWS is one crucial factor accounting for inadequate treatment outcome, which needs to be fully characterized. This study aims to quantitatively characterize the morphology of laser-resistant PWS blood vessels in the upper papillary dermis using in vivo reflectance confocal microscopy (RCM).Study design/materials and methodsA total of 42 PWS subjects receiving laser treatment from August 2016 through July 2018 were enrolled into this study. Thirty-three subjects had facial PWS; nine had extremity PWS. All subject's PWS received multiplex 585/1,064 nm laser treatment. RCM images were taken before and after treatment. The density, diameter, blood flow, and depth of PWS blood vessels were analyzed.ResultsWe found 44.4% PWS on the extremities (four out of nine subjects) were laser-resistant, which was significantly higher (P < 0.001) when compared with those PWS on the face (15.2%, 5 out of 33 subjects). The laser-resistant facial PWS blood vessels had significantly higher blood flow (1.35 ± 0.26 U vs. 0.89 ± 0.22 U, P < 0.001), larger blood vessel diameters (109.60 ± 18.24 µm vs. 84.36 ± 24.04 µm, P = 0.033) and were located deeper in the skin (106.01 ± 13.87 µm vs. 87.82 ± 12.57 µm, P < 0.001) in the skin when compared with laser-responsive PWS on the face. The average PWS blood vessel density (17.01 ± 4.63/mm2 vs. 16.61 ± 4.44/mm2 , P = 0.857) was not correlated to the laser resistance.ConclusionsLaser-resistant PWS blood vessels had significantly higher blood flow, larger diameters, and were located deeper in the skin. RCM can be a valuable tool for a prognostic evaluation on laser-resistant lesions before treatment, thereby providing guidance for tailored laser treatment protocols, which may improve the therapeutic outcome. The limitations for this study include relative small sample size and acquisitions of different blood vessels before and after 2 months of treatment. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc

Recent Results on Searches for Pentaquark States from STAR at RHIC

We present results on pentaquark searches from nuclear collisions at RHIC with the STAR detector system. An intriguing peak has been observed in the invariant mass distribution of $pK^{+}+\overline{p}K^{-}$ from 18.6 Million d+Au collision events at $\sqrt{s_{_{NN}}} = 200$~GeV. The peak centers at a mass $1528 \pm 2 \pm 5$~MeV/c$^{2}$ and the FWHM $\sim15$ MeV/c$^{2}$ limited by detector responses. The statistical significance of the peak is $4.2\sigma$. Such a state if confirmed is manifestly exotic and implies a family of isospin one states. A weak signal of less statistical significance ($\sim3\sigma$) has been observed in 5.6M Au+Au collision events at 62.4 GeV. Searches in 10.7M Au+Au collision events at 200 GeV yield no significant signal. The Au+Au results neither confirm nor rule out the d+Au observation as a possible state.Comment: To appear in proceedings of International Conference on QCD and Hadron Physics at Beijing, June 200

Markov quantum fields on a manifold

We study scalar quantum field theory on a compact manifold. The free theory is defined in terms of functional integrals. For positive mass it is shown to have the Markov property in the sense of Nelson. This property is used to establish a reflection positivity result when the manifold has a reflection symmetry. In dimension d=2 we use the Markov property to establish a sewing operation for manifolds with boundary circles. Also in d=2 the Markov property is proved for interacting fields.Comment: 14 pages, 1 figure, Late

Superfluid Bosons and Flux Liquids: Disorder, Thermal Fluctuations, and Finite-Size Effects

The influence of different types of disorder (both uncorrelated and correlated) on the superfluid properties of a weakly interacting or dilute Bose gas, as well as on the corresponding quantities for flux line liquids in high-temperature superconductors at low magnetic fields are reviewed, investigated and compared. We exploit the formal analogy between superfluid bosons and the statistical mechanics of directed lines, and explore the influence of the different "imaginary time" boundary conditions appropriate for a flux line liquid. For superfluids, we discuss the density and momentum correlations, the condensate fraction, and the normal-fluid density as function of temperature for two- and three-dimensional systems subject to a space- and time-dependent random potential as well as conventional point-, line-, and plane-like defects. In the case of vortex liquids subject to point disorder, twin boundaries, screw dislocations, and various configurations of columnar damage tracks, we calculate the corresponding quantities, namely density and tilt correlations, the ``boson'' order parameter, and the tilt modulus. The finite-size corrections due to periodic vs. open "imaginary time" boundary conditions differ in interesting and important ways. Experimental implications for vortex lines are described briefly.Comment: 78 pages, RevTex, 4 figures included (sorry, there are no ps-files for the remaining 2 figures; if needed, please send mail to [email protected]); brief erratum appended (2 pages

Management of an Accessory Bile Duct Leak Following Pancreaticoduodenectomy: A Novel Approach Utilizing a Percutaneous and Endoscopic Rendezvous.

Biliary leaks are uncommon but morbid complications of pancreaticoduodenectomies, which have historically been managed with percutaneous drainage, reoperation, or a combination of both. We report a de novo percutaneous-endoscopic hepaticojejunostomy from an anomalous right hepatic duct injured during pancreaticoduodenectomy to the afferent bowel limb. The percutaneous-endoscopic hepaticojejunostomy was stented to allow for tract formation with successful stent removal after 5.5 months. One year after the creation of the percutaneous-endoscopic hepaticojejunostomy, the patient remains clinically well without evidence of biliary leak or obstruction

Adaptive locomotion of artificial microswimmers

Bacteria can exploit mechanics to display remarkable plasticity in response to locally changing physical and chemical conditions. Compliant structures play a striking role in their taxis behavior, specifically for navigation inside complex and structured environments. Bioinspired mechanisms with rationally designed architectures capable of large, nonlinear deformation present opportunities for introducing autonomy into engineered small-scale devices. This work analyzes the effect of hydrodynamic forces and rheology of local surroundings on swimming at low Reynolds number, identifies the challenges and benefits of utilizing elastohydrodynamic coupling in locomotion, and further develops a suite of machinery for building untethered microrobots with self-regulated mobility. We demonstrate that coupling the structural and magnetic properties of artificial microswimmers with the dynamic properties of the fluid leads to adaptive locomotion in the absence of on-board sensors

Transition amplitudes and sewing properties for bosons on the Riemann sphere

We consider scalar quantum fields on the sphere, both massive and massless. In the massive case we show that the correlation functions define amplitudes which are trace class operators between tensor products of a fixed Hilbert space. We also establish certain sewing properties between these operators. In the massless case we consider exponential fields and have a conformal field theory. In this case the amplitudes are only bilinear forms but still we establish sewing properties. Our results are obtained in a functional integral framework.Comment: 33 page