172 research outputs found
CGOF++: Controllable 3D Face Synthesis with Conditional Generative Occupancy Fields
Capitalizing on the recent advances in image generation models, existing
controllable face image synthesis methods are able to generate high-fidelity
images with some levels of controllability, e.g., controlling the shapes,
expressions, textures, and poses of the generated face images. However,
previous methods focus on controllable 2D image generative models, which are
prone to producing inconsistent face images under large expression and pose
changes. In this paper, we propose a new NeRF-based conditional 3D face
synthesis framework, which enables 3D controllability over the generated face
images by imposing explicit 3D conditions from 3D face priors. At its core is a
conditional Generative Occupancy Field (cGOF++) that effectively enforces the
shape of the generated face to conform to a given 3D Morphable Model (3DMM)
mesh, built on top of EG3D [1], a recent tri-plane-based generative model. To
achieve accurate control over fine-grained 3D face shapes of the synthesized
images, we additionally incorporate a 3D landmark loss as well as a volume
warping loss into our synthesis framework. Experiments validate the
effectiveness of the proposed method, which is able to generate high-fidelity
face images and shows more precise 3D controllability than state-of-the-art
2D-based controllable face synthesis methods.Comment: This article is an extension of the NeurIPS'22 paper arXiv:2206.0836
Controllable 3D Face Synthesis with Conditional Generative Occupancy Fields
Capitalizing on the recent advances in image generation models, existing
controllable face image synthesis methods are able to generate high-fidelity
images with some levels of controllability, e.g., controlling the shapes,
expressions, textures, and poses of the generated face images. However, these
methods focus on 2D image generative models, which are prone to producing
inconsistent face images under large expression and pose changes. In this
paper, we propose a new NeRF-based conditional 3D face synthesis framework,
which enables 3D controllability over the generated face images by imposing
explicit 3D conditions from 3D face priors. At its core is a conditional
Generative Occupancy Field (cGOF) that effectively enforces the shape of the
generated face to commit to a given 3D Morphable Model (3DMM) mesh. To achieve
accurate control over fine-grained 3D face shapes of the synthesized image, we
additionally incorporate a 3D landmark loss as well as a volume warping loss
into our synthesis algorithm. Experiments validate the effectiveness of the
proposed method, which is able to generate high-fidelity face images and shows
more precise 3D controllability than state-of-the-art 2D-based controllable
face synthesis methods. Find code and demo at
https://keqiangsun.github.io/projects/cgof
Construction of a high-density genetic map using specific length amplified fragment markers and identification of a quantitative trait locus for anthracnose resistance in walnut (Juglans regia L.)
Antibody-drug conjugates in urinary tumors: clinical application, challenge, and perspectives
Urinary tumors primarily consist of kidney, urothelial, and prostate malignancies, which pose significant treatment challenges, particularly in advanced stages. Antibody-drug conjugates (ADCs) have emerged as a promising therapeutic approach, combining monoclonal antibody specificity with cytotoxic chemotherapeutic payloads. This review highlights recent advancements, opportunities, and challenges in ADC application for urinary tumors. We discuss the FDA-approved ADCs and other novel ADCs under investigation, emphasizing their potential to improve patient outcomes. Furthermore, we explore strategies to address challenges, such as toxicity management, predictive biomarker identification, and resistance mechanisms. Additionally, we examine the integration of ADCs with other treatment modalities, including immune checkpoint inhibitors, targeted therapies, and radiation therapy. By addressing these challenges and exploring innovative approaches, the development of ADCs may significantly enhance therapeutic options and outcomes for patients with advanced urinary tumor
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