UniM2^2AE: Multi-modal Masked Autoencoders with Unified 3D Representation for 3D Perception in Autonomous Driving

Masked Autoencoders (MAE) play a pivotal role in learning potent representations, delivering outstanding results across various 3D perception tasks essential for autonomous driving. In real-world driving scenarios, it's commonplace to deploy multiple sensors for comprehensive environment perception. While integrating multi-modal features from these sensors can produce rich and powerful features, there is a noticeable gap in MAE methods addressing this integration. This research delves into multi-modal Masked Autoencoders tailored for a unified representation space in autonomous driving, aiming to pioneer a more efficient fusion of two distinct modalities. To intricately marry the semantics inherent in images with the geometric intricacies of LiDAR point clouds, the UniM$^2$AE is proposed. This model stands as a potent yet straightforward, multi-modal self-supervised pre-training framework, mainly consisting of two designs. First, it projects the features from both modalities into a cohesive 3D volume space, ingeniously expanded from the bird's eye view (BEV) to include the height dimension. The extension makes it possible to back-project the informative features, obtained by fusing features from both modalities, into their native modalities to reconstruct the multiple masked inputs. Second, the Multi-modal 3D Interactive Module (MMIM) is invoked to facilitate the efficient inter-modal interaction during the interaction process. Extensive experiments conducted on the nuScenes Dataset attest to the efficacy of UniM$^2$AE, indicating enhancements in 3D object detection and BEV map segmentation by 1.2\%(NDS) and 6.5\% (mIoU), respectively. Code is available at https://github.com/hollow-503/UniM2AE.Comment: Code available at https://github.com/hollow-503/UniM2A

Anomalous Transport in Sketched Nanostructures at the LaAlO3/SrTiO3 Interface

The oxide heterostructure LaAlO3/SrTiO3 supports a two-dimensional electron liquid with a variety of competing phases including magnetism, superconductivity and weak antilocalization due to Rashba spin-orbit coupling. Further confinement of this 2D electron liquid to the quasi-one-dimensional regime can provide insight into the underlying physics of this system and reveal new behavior. Here we describe magnetotransport experiments on narrow LaAlO3/SrTiO3 structures created by a conductive atomic force microscope lithography technique. Four-terminal local transport measurements on ~10-nm-wide Hall bar structures yield longitudinal resistances that are comparable to the resistance quantum h/e2 and independent of the channel length. Large nonlocal resistances (as large as 10^4 ohms) are observed in some but not all structures with separations between current and voltage that are large compared to the 2D mean-free path. The nonlocal transport is strongly suppressed by the onset of superconductivity below ~200 mK. The origin of these anomalous transport signatures is not understood, but may arise from coherent transport defined by strong spin-orbit coupling and/or magnetic interactions

Staged open reduction and internal fixation with double-locking plates to treat bilateral distal femur periprosthetic fractures after total knee arthroplasty: A case report

BackgroundThe incidence of periprosthetic fractures after total knee arthroplasty (TKA) increases in parallel with the number of procedures. Comminuted fractures along the primary fracture line extending to the edge of the prosthesis are challenging, and bilateral fractures are rarely reported, especially with open injuries.Case presentationA 65-year-old female had undergone bilateral TKA in our hospital 5 years before admission. She was admitted with a traumatic bilateral Rorabeck type II B distal femur periprosthetic fracture (closed right, open left, Gustilo II) and was treated with bilateral staged open reduction and internal fixation (ORIF) with double-locking plates. The patient experienced a prolonged delayed fracture union and finally healed around 21 months postoperatively. The function was satisfactory after 4 years of follow-up.ConclusionORIF with double-locking plates can be used to treat Rorabeck II B periprosthetic fracture where the primary fracture line extends beyond the edge of the prosthesis; however, there may be delayed healing or nonunion. Patients need to undergo long-term rehabilitation and endure long disability times and require good rehabilitation nursing care. Once they achieve bone healing, the treatment achieves bone preservation and substantial prosthesis survival

Immobilization of lipase on chitosan beads for removal of pitch particles from whitewater during papermaking

Pitch deposits originating from alkaline peroxide bleaching of mechanical pulps can seriously decrease the runnability of the paper machine when efforts have been made to increase the reuse of process water. In order to degrade pitch particles present in whitewater, lipase was immobilized on chitosan beads using a binary method. The operational stability of the immobilized lipase and its efficacy for treating whitewater were also preliminary studied. The results showed that the highest activity of immobilized lipase was achieved by using 0.5% 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) for activation and 0.0025% glutaraldehyde for cross-linking chitosan. The immobilized lipase also exhibited very good operational stability, and the pitch particles present in whitewater could be reduced by 66.8% after treatment with the immobilized lipase

Advances in CRISPR/Cas gene therapy for inborn errors of immunity

Inborn errors of immunity (IEIs) are a group of inherited disorders caused by mutations in the protein-coding genes involved in innate and/or adaptive immunity. Hematopoietic stem cell transplantation (HSCT) is a mainstay definitive therapy for many severe IEIs. However, the lack of HLA-matched donors increases the risk of developing severe immunological complications. Gene therapy provides long-term clinical benefits and could be an attractive therapeutic strategy for IEIs. In this review, we describe the development and evolution of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated proteins (Cas) gene-editing systems, including double-strand break (DSB)-based gene editing and DSB-free base editing or prime editing systems. Here, we discuss the advances in and issues associated with CRISPR/Cas gene editing tools and their potential as therapeutic alternatives for IEIs. We also highlight the progress of preclinical studies for the treatment of human genetic diseases, including IEIs, using CRISR/Cas and ongoing clinical trials based on this versatile technology