Učinak dodataka prehrani acetaminofena i vitamina C na stres i upalni odgovor u korejske autohtone pasmine goveda cijepljene protiv slinavke i šapa - kratko priopćenje

This study evaluated the effect of a combination of acetaminophen and vitamin C (CAV) for reduction of stress and inflammatory responses in calves vaccinated with foot-and-mouth disease (FMD) vaccine. Twenty-five calves were divided into five groups of 5 calves. The negative control was non-vaccination and non-drug treatment. The positive control, and experimental groups I, II and III were vaccinated with FMD vaccine and treated with CAV at concentrations of 0.0, 0.5, 1.0 and 2.0 kg/ton feed, respectively, for five consecutive days post-vaccination. On day 5 post-treatment, serum cortisols and tumor necrosis factor-α (TNF-α) were significantly decreased in all treatment groups compared with the positive control (P<0.05). However, there was no significant difference in serum cortisol and TNF-α levels between experimental groups I and II and the negative control. The results from this study suggest that CAV may be a useful drug for control of the stress and inflammation caused by FMD vaccination in calves.U ovom se radu istražuje učinak kombinacije acetaminofena i vitamina C (CAV) na smanjenje stresa i upalnog odgovora u teladi cijepljene protiv slinavke i šapa. Ukupno 25 životinja podijeljeno je u pet skupina po pet životinja. Životinje u negativnoj kontrolnoj skupini nisu cijepljene i nisu dobile dodatke prehrani. Životinje u pozitivnoj kontrolnoj skupini i pokusnim skupinama I, II i III cijepljene su cjepivom protiv slinavke i šapa i dobile su dodatak prehrani CAV u koncentracijama od 0,0, 0,5, 1,0 i 2,0 kg/toni hrane, pet uzastopnih dana poslije cijepljenja. Peti dan nakon tretmana serumski kortizol i faktor nekroze tumora alfa (TNF-α) bili su znakovito smanjeni u svim pokusnim skupinama u usporedbi s pozitivnom kontrolnom skupinom (P<0,05). Nije bilo znakovite razlike u vrijednostima serumskog kortizola i TNF-α između pokusne skupine 1 i 2 i negativne kontrolne skupine. Rezultati ovoga istraživanja upućuju na to da bi CAV mogao biti koristan u kontroli stresa i upale uzrokovane cjepivom protiv slinavke i šapa u teladi

Analysis of patterns of livestock movements in the Cattle Corridor of Uganda for risk-based surveillance of infectious diseases

IntroductionThe knowledge of animal movements is key to formulating strategic animal disease control policies and carrying out targeted surveillance. This study describes the characteristics of district-level cattle, small ruminant, and pig trade networks in the Cattle Corridor of Uganda between 2019 and 2021.MethodologyThe data for the study was extracted from 7,043 animal movement permits (AMPs) obtained from the Ministry of Agriculture, Animal Industry and Fisheries (MAAIF) of Uganda. Most of the data was on cattle (87.2%), followed by small ruminants (11.2%) and pigs (1.6%). Two types of networks representing animal shipments between districts were created for each species based on monthly (n = 30) and seasonal (n = 10) temporal windows. Measures of centrality and cohesiveness were computed for all the temporal windows and our analysis identified the most central districts in the networks.ResultsThe median in-degree for monthly networks ranged from 0–3 for cattle, 0–1 for small ruminants and 0–1 for pigs. The highest median out-degrees for cattle, small ruminant and pig monthly networks were observed in Lira, Oyam and Butambala districts, respectively. Unlike the pig networks, the cattle and small ruminant networks were found to be of small-world and free-scale topologies.DiscussionThe cattle and small ruminant trade movement networks were also found to be highly connected, which could facilitate quick spread of infectious animal diseases across these networks. The findings from this study highlighted the significance of characterizing animal movement networks to inform surveillance, early detection, and subsequent control of infectious animal disease outbreaks