345 research outputs found
A novel frequency response analysis model applicable to high-penetration wind power grid
The decoupling relationship and low inertia characteristics of wind turbine generator system (WTGS) make the system frequency response more complex. In order to evaluate the frequency stability of high-penetration wind power grid, it is significant to establish an exactly frequency response analysis model. Due to the features of wide spatial distribution and large number of WTGS in the power grid, the wind speed and actual operating state faced by WTGS in different regions have obvious discrepancy, which makes the traditional frequency response models that merely considers the single operating state of WTGS have evident limitations. Therefore, in order to consider the discrepancy of frequency regulation characteristics caused by the spatial dispersion of WTGS, an improved frequency response modeling method which can take into account the frequency regulation characteristics of multiple wind speeds is proposed. This method uses small signal analysis theory and fuzzy control method to construct an improved equivalent aggregation model of WTGS. Combining this model with the typical system frequency response (SFR) model, a novel frequency response model considering different wind conditions and different frequency regulation characteristics of WTGSs is established. Finally, an improved IEEE-118 bus system is used for case analysis to verify the correctness and superiority of the proposed method for high-penetration wind power grid. (C) 2022 The Authors. Published by Elsevier Ltd
Sequential recommender systems: Challenges, progress and prospects
© 2019 International Joint Conferences on Artificial Intelligence. All rights reserved. The emerging topic of sequential recommender systems (SRSs) has attracted increasing attention in recent years. Different from the conventional recommender systems (RSs) including collaborative filtering and content-based filtering, SRSs try to understand and model the sequential user behaviors, the interactions between users and items, and the evolution of users' preferences and item popularity over time. SRSs involve the above aspects for more precise characterization of user contexts, intent and goals, and item consumption trend, leading to more accurate, customized and dynamic recommendations. In this paper, we provide a systematic review on SRSs. We first present the characteristics of SRSs, and then summarize and categorize the key challenges in this research area, followed by the corresponding research progress consisting of the most recent and representative developments on this topic. Finally, we discuss the important research directions in this vibrant area
Modeling multi-purpose sessions for next-item recommendations via mixture-channel purpose routing networks
© 2019 International Joint Conferences on Artificial Intelligence. All rights reserved. A session-based recommender system (SBRS) suggests the next item by modeling the dependencies between items in a session. Most of existing SBRSs assume the items inside a session are associated with one (implicit) purpose. However, this may not always be true in reality, and a session may often consist of multiple subsets of items for different purposes (e.g., breakfast and decoration). Specifically, items (e.g., bread and milk) in a subset have strong purpose-specific dependencies whereas items (e.g., bread and vase) from different subsets have much weaker or even no dependencies due to the difference of purposes. Therefore, we propose a mixture-channel model to accommodate the multi-purpose item subsets for more precisely representing a session. To address the shortcomings in existing SBRSs, this model recommends more diverse items to satisfy different purposes. Accordingly, we design effective mixture-channel purpose routing networks (MCPRNs) with a purpose routing network to detect the purposes of each item and assign them into the corresponding channels. Moreover, a purpose-specific recurrent network is devised to model the dependencies between items within each channel for a specific purpose. The experimental results show the superiority of MCPRN over the state-of-the-art methods in terms of both recommendation accuracy and diversity
Intention Nets: Psychology-Inspired User Choice Behavior Modeling for Next-Basket Prediction
Human behaviors are complex, which are often observed as a sequence of heterogeneous actions. In this paper, we take user choices for shopping baskets as a typical case to study the complexity of user behaviors. Most of existing approaches often model user behaviors in a mechanical way, namely treating a user action sequence as homogeneous sequential data, such as hourly temperatures, which fails to consider the complexity in user behaviors. In fact, users' choices are driven by certain underlying intentions (e.g., feeding the baby or relieving pain) according to Psychological theories. Moreover, the durations of intentions to drive user actions are quite different; some of them may be persistent while others may be transient. According to Psychological theories, we develop a hierarchical framework to describe the goal, intentions and action sequences, based on which, we design Intention Nets (IntNet). In IntNet, multiple Action Chain Nets are constructed to model the user actions driven by different intentions, and a specially designed Persistent-Transient Intention Unit models the different intention durations. We apply the IntNet to next-basket prediction, a recent challenging task in recommender systems. Extensive experiments on real-world datasets show the superiority of our Psychology-inspired model IntNet over the state-of-the-art approaches.</jats:p
Intention2Basket: A neural intention-driven approach for dynamic next-basket planning
User purchase behaviours are complex and dynamic, which are usually observed as multiple choice actions across a sequence of shopping baskets. Most of the existing next-basket prediction approaches model user actions as homogeneous sequence data without considering complex and heterogeneous user intentions, impeding deep understanding of user behaviours from the perspective of human inside drivers and thus reducing the prediction performance. Psychological theories have indicated that user actions are essentially driven by certain underlying intentions (e.g., diet and entertainment). Moreover, different intentions may influence each other while different choices usually have different utilities to accomplish an intention. Inspired by such psychological insights, we formalize the next-basket prediction as an Intention Recognition, Modelling and Accomplishing problem and further design the Intention2Basket (Int2Ba in short) model. In Int2Ba, an Intention Recognizer, a Coupled Intention Chain Net, and a Dynamic Basket Planner are specifically designed to respectively recognize, model and accomplish the heterogeneous intentions behind a sequence of baskets to better plan the next-basket. Extensive experiments on real-world datasets show the superiority of Int2Ba over the state-of-the-art approaches
Graph Learning based Recommender Systems: A Review
Recent years have witnessed the fast development of the emerging topic of Graph Learning based Recommender Systems (GLRS). GLRS employ advanced graph learning approaches to model users' preferences and intentions as well as items' characteristics for recommendations. Differently from other RS approaches, including content-based filtering and collaborative filtering, GLRS are built on graphs where the important objects, e.g., users, items, and attributes, are either explicitly or implicitly connected. With the rapid development of graph learning techniques, exploring and exploiting homogeneous or heterogeneous relations in graphs are a promising direction for building more effective RS. In this paper, we provide a systematic review of GLRS, by discussing how they extract important knowledge from graph-based representations to improve the accuracy, reliability and explainability of the recommendations. First, we characterize and formalize GLRS, and then summarize and categorize the key challenges and main progress in this novel research area
Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer
Lung cancer is the leading cause of cancer deaths worldwide, with a five-year overall survival rate of only 15%. Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein inhibiting PP2A in many human malignancies. However, whether CIP2A can be a new drug target for lung cancer is largely unclear.Normal and malignant lung tissues were derived from 60 lung cancer patients from southern China. RT-PCR, Western blotting and immunohistochemistry were used to evaluate the expression of CIP2A. We found that among the 60 patients, CIP2A was undetectable or very low in paratumor normal tissues, but was dramatically elevated in tumor samples in 38 (63.3%) patients. CIP2A overexpression was associated with cigarette smoking. Silencing CIP2A by siRNA inhibited the proliferation and clonogenic activity of lung cancer cells. Intriguingly, we found a natural compound, rabdocoetsin B which is extracted from a Traditional Chinese Medicinal herb Rabdosia coetsa, could induce down-regulation of CIP2A and inactivation of Akt pathway, and inhibit proliferation and induce apoptosis in a variety of lung cancer cells.Our findings strongly indicate that CIP2A could be an effective target for lung cancer drug development, and the therapeutic potentials of CIP2A-targeting agents warrant further investigation
ETISEQ – an algorithm for automated elution time ion sequencing of concurrently fragmented peptides for mass spectrometry-based proteomics
<p>Abstract</p> <p>Background</p> <p>Concurrent peptide fragmentation (i.e. shotgun CID, parallel CID or MS<sup>E</sup>) has emerged as an alternative to data-dependent acquisition in generating peptide fragmentation data in LC-MS/MS proteomics experiments. Concurrent peptide fragmentation data acquisition has been shown to be advantageous over data-dependent acquisition by providing greater detection dynamic range and providing more accurate quantitative information. Nevertheless, concurrent peptide fragmentation data acquisition remains to be widely adopted due to the lack of published algorithms designed specifically to process or interpret such data acquired on any mass spectrometer.</p> <p>Results</p> <p>An algorithm called Elution Time Ion Sequencing (ETISEQ), has been developed to enable automated conversion of concurrent peptide fragmentation data acquisition data to LC-MS/MS data. ETISEQ generates MS/MS-like spectra based on the correlation of precursor and product ion elution profiles. The performance of ETISEQ is demonstrated using concurrent peptide fragmentation data from tryptic digests of standard proteins and whole influenza virus. It is shown that the number of unique peptides identified from the digests is broadly comparable between ETISEQ processed concurrent peptide fragmentation data and the data-dependent acquired LC-MS/MS data.</p> <p>Conclusion</p> <p>The ETISEQ algorithm has been designed for easy integration with existing MS/MS analysis platforms. It is anticipated that it will popularize concurrent peptide fragmentation data acquisition in proteomics laboratories.</p
Identical twins:one with anti-glomerular basement membrane glomerulonephritis,the other with systemic lupus erythematosus
Limits on WWZ and WW\gamma couplings from p\bar{p}\to e\nu jj X events at \sqrt{s} = 1.8 TeV
We present limits on anomalous WWZ and WW-gamma couplings from a search for
WW and WZ production in p-bar p collisions at sqrt(s)=1.8 TeV. We use p-bar p
-> e-nu jjX events recorded with the D0 detector at the Fermilab Tevatron
Collider during the 1992-1995 run. The data sample corresponds to an integrated
luminosity of 96.0+-5.1 pb^(-1). Assuming identical WWZ and WW-gamma coupling
parameters, the 95% CL limits on the CP-conserving couplings are
-0.33<lambda<0.36 (Delta-kappa=0) and -0.43<Delta-kappa<0.59 (lambda=0), for a
form factor scale Lambda = 2.0 TeV. Limits based on other assumptions are also
presented.Comment: 11 pages, 2 figures, 2 table
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