On determination of the geometric cosmological constant from the OPERA experiment of superluminal neutrinos

The recent OPERA experiment of superluminal neutrinos has deep consequences in cosmology. In cosmology a fundamental constant is the cosmological constant. From observations one can estimate the effective cosmological constant $\Lambda_{eff}$ which is the sum of the quantum zero point energy $\Lambda_{dark energy}$ and the geometric cosmological constant $\Lambda$. The OPERA experiment can be applied to determine the geometric cosmological constant $\Lambda$. It is the first time to distinguish the contributions of $\Lambda$ and $\Lambda_{dark energy}$ from each other by experiment. The determination is based on an explanation of the OPERA experiment in the framework of Special Relativity with de Sitter space-time symmetry.Comment: 7 pages, no figure

Prevalence of Pediculus Capitis Infestation Among School Children of Chinese Refugees Residing in Mountainous Areas of Northern Thailand

An epidemiologic survey of Pediculus capitis infestation among Akka aboriginal and Han children of Chinese refugees living in mountainous areas at elevations of 1,100 to 1,400 m in Chiang-Rai Province of northern Thailand was conducted during January 2003. Of the 303 children examined, 43 (14.2%) had P. capitis infestation. The overall infestation rate for P. capitis in Akka children (29.3%, 12/41) was significantly higher than that in Han children (11.8%, 31/262; c2 = 8.161, p = 0.002). The prevalence in Akka (52.2%, 12/23) and Han girls (19.7%, 31/157) was higher than that in Akka (0%) and Han boys (0%), respectively (p < 0.001), and the prevalence was higher in Akka girls than in Han girls (c2 = 10.978, p = 0.001). The high prevalence of P. capitis infestation among these girls was possibly due to poor environmental hygiene and unavailability of sufficient water

Superluminal Neutrinos from Special Relativity with de Sitter Space-time Symmetry

We explore the recent OPERA experiment of superluminal neutrinos in the framework of Special Relativity with de Sitter space-time symmetry (dS-SR). According to Einstein a photon is treated as a massless particle in the framework of Special Relativity. In Special Relativity (SR) we have the universal parameter $c$, the photon velocity $c_{photon}$ and the phase velocity of a light wave in vacuum $c_{wave}=\lambda\nu$. Due to the null experiments of Michelson-Morley we have $c=c_{wave}$. The parameter $c_{photon}$ is determined by the Noether charges corresponding to the space-time symmetries of SR. In Einstein's Special Relativity (E-SR) we have $c=c_{photon}$. In dS-SR, i.e. the Special Relativity with SO(4,1) de Sitter space-time symmetry, we have $c_{photon}>c$. In this paper, the OPERA datum are examined in the framework of dS-SR. We show that OPREA anomaly is in agreement with the prediction of dS-SR with $R\simeq 1.95\times 10^{12}l.y.$ Based on the $p$-$E$ relation of dS-SR, we also prove that the Cohen and Glashow's argument of possible superluminal neutrino's Cherenkov-like radiation is forbidden. We conclude that OPERA and ICARUS results are consistent and they are explained in the dS-SR framework.Comment: 14 pages, 2 figure

Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy

Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered. Fuzi, the lateral roots of Aconitum carmichaelii, shows unique efficacy in reviving Yang for resuscitation, which has been widely used in clinics. As a main cardiotonic component of Fuzi, mesaconine has been proven effective in various cardiomyopathy models. Here, we aimed to define a previously unrevealed cardioprotective mechanism of mesaconine-mediated restoration of obstructive mitophagy. The functional implications of mesaconine were evaluated in doxorubicin (DOX)-induced heart failure models. DOX-treated mice showed characteristic cardiac dysfunction, ectopic myocardial energy disorder, and impaired mitophagy in cardiomyocytes, which could be remarkably reversed by mesaconine. The cardioprotective effect of mesaconine was primarily attributed to its ability to promote the restoration of mitophagy in cardiomyocytes, as evidenced by elevated expression of PINK1, a key mediator of mitophagy induction. Silencing PINK1 or deactivating mitophagy could completely abolish the protective effects of mesaconine. Together, our findings suggest that the cardioprotective effects of mesaconine appear to be dependent on the activation of PINK1-induced mitophagy and that mesaconine may constitute a promising therapeutic agent for the treatment of heart failure

A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol

Menthol is a widely-used cooling and flavoring agent derived from mint leaves. In the peripheral nervous system, menthol regulates sensory transduction by activating TRPM8 channels residing specifically in primary sensory neurons. Although behavioral studies have implicated menthol actions in the brain, no direct central target of menthol has been identified. Here we show that menthol reduces the excitation of rat hippocampal neurons in culture and suppresses the epileptic activity induced by pentylenetetrazole injection and electrical kindling in vivo. We found menthol not only enhanced the currents induced by low concentrations of GABA but also directly activated GABAA receptor (GABAAR) in hippocampal neurons in culture. Furthermore, in the CA1 region of rat hippocampal slices, menthol enhanced tonic GABAergic inhibition although phasic GABAergic inhibition was unaffected. Finally, the structure-effect relationship of menthol indicated that hydroxyl plays a critical role in menthol enhancement of tonic GABAAR. Our results thus reveal a novel cellular mechanism that may underlie the ambivalent perception and psychophysical effects of menthol and underscore the importance of tonic inhibition by GABAARs in regulating neuronal activity

Demonstration of laser-produced neutron diagnostic by radiative capture gamma-rays

We report a new scenario of time-of-flight (TOF) technique in which fast neutrons and delayed gamma-ray signals were both recorded in a millisecond time window in harsh environments induced by high-intensity lasers. The delayed gamma signals, arriving far later than the original fast neutron and often being ignored previously, were identified to be the results of radiative captures of thermalized neutrons. The linear correlation between gamma photon number and the fast neutron yield shows that these delayed gamma events can be employed for neutron diagnosis. This method can reduce the detecting efficiency dropping problem caused by prompt high-flux gamma radiation, and provides a new way for neutron diagnosing in high-intensity laser-target interaction experiments

Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo

Synaptic long-term depression (LTD) is believed to underlie critical mnemonic processes in the adult hippocampus. The roles of the metabotropic and ionotropic actions of glutamate in the induction of synaptic LTD by electrical low-frequency stimulation (LFS) in the living adult animal is poorly understood. Here we examined the requirement for metabotropic glutamate (mGlu) and NMDA receptors in LTD induction in anaesthetized adult rats. LTD induction was primarily dependent on NMDA receptors and required the involvement of both the ion channel function and GluN2B subunit of the receptor. Endogenous mGlu5 receptor activation necessitated the local application of relatively high doses of either competitive or non-competitive NMDA receptor antagonists to block LTD induction. Moreover, boosting endogenous glutamate activation of mGlu5 receptors with a positive allosteric modulator lowered the threshold for NMDA receptor-dependent LTD induction by weak LFS. The present data provide support in the living animal that NMDA receptor-dependent LTD is boosted by endogenously released glutamate activation of mGlu5 receptors. Given the predominant perisynaptic location of mGlu5 receptors, the present findings emphasize the need to further evaluate the contribution and mechanisms of these receptors in NMDA receptor-dependent synaptic plasticity in the adult hippocampus in vivo