Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)

To ensure that homeostasis of the immune system is maintained, the sensitivity of lymphocytes to Fas-mediated apoptosis is differentially regulated during their activation. The molecular mechanisms that link the activation program of lymphocytes to changes in sensitivity to Fas-mediated apoptosis have, however, not been fully characterized. In these studies, we have investigated whether Fas-mediated apoptosis can be regulated by interferon regulatory factor 4 (IRF-4), a lymphoid-restricted member of the IRF family of transcription factors. IRF-4 expression is upregulated during lymphocyte activation and IRF-4–deficient mice have defects in both lymphocyte activation and homeostasis. Here, we show that stable expression of IRF-4 in a human lymphoid cell line that normally lacks IRF-4 leads to a significantly enhanced apoptotic response on Fas receptor engagement. A systematic examination of the downstream effectors of Fas signaling in IRF-4–transfected cells demonstrates an increased activation of caspase-8, as well as an increase in Fas receptor polarization. We demonstrate that IRF-4–deficient mice display defects in activation-induced cell death, as well as superantigen-induced deletion, and that these defects are accompanied by impairments in Fas receptor polarization. These data suggest that IRF-4, by modulating the efficiency of the Fas-mediated death signal, is a novel participant in the regulation of lymphoid cell apoptosis

Methological quality of systematic reviews and meta-analyses on acupuncture for stroke: a review of review

Objective: To assess the methodological quality of systematic reviews and meta-analyses regarding acupuncture intervention for stroke and the primary studies within them. Methods: Two researchers searched PubMed, Cumulative index to Nursing and Allied Health Literature, Embase, ISI Web of Knowledge, Cochrane, Allied and Complementary Medicine, Ovid Medline, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang and Traditional Chinese Medical Database to identify systematic reviews and meta-analyses about acupuncture for stroke published from the inception to December 2016. Review characteristics and the criteria for assessing the primary studies within reviews were extracted. The methodological quality of the reviews was assessed using adapted Oxman and Guyatt Scale. The methodological quality of primary studies was also assessed. Results: Thirty-two eligible reviews were identified, 15 in English and 17 in Chinese. The English reviews were scored higher than the Chinese reviews (P=0.025), especially in criteria for avoiding bias and the scope of search. All reviews used the quality criteria to evaluate the methodological quality of primary studies, but some criteria were not comprehensive. The primary studies, in particular the Chinese reviews, had problems with randomization, allocation concealment, blinding, dropouts and withdrawals, intent-to-treat analysis and adverse events. Conclusions: Important methodological flaws were found in Chinese systematic reviews and primary studies. It was necessary to improve the methodological quality and reporting quality of both the systematic reviews published in China and primary studies on acupuncture for stroke

Efficient superdense coding in the presence of non-Markovian noise

Many quantum information tasks rely on entanglement, which is used as a resource, for example, to enable efficient and secure communication. Typically, noise, accompanied by loss of entanglement, reduces the efficiency of quantum protocols. We develop and demonstrate experimentally a superdense coding scheme with noise, where the decrease of entanglement in Alice's encoding state does not reduce the efficiency of the information transmission. Having almost fully dephased classical two-photon polarization state at the time of encoding with concurrence $0.163\pm0.007$, we reach values of mutual information close to $1.52\pm 0.02$ ($1.89\pm 0.05$) with 3-state (4-state) encoding. This high efficiency relies both on non-Markovian features, that Bob exploits just before his Bell-state measurement, and on very high visibility ($99.6\%\pm0.1\%$) of the Hong-Ou-Mandel interference within the experimental set-up. Our proof-of-principle results with measurements on mutual information pave the way for exploiting non-Markovianity to improve the efficiency and security of quantum information processing tasks.Comment: 6 pages, 4 figures. V2: Minor change

Preparation of multiphoton high-dimensional GHZ state

Multipartite high-dimensional entanglement presents different physics from multipartite two-dimensional entanglement. However, how to prepare multipartite high-dimensional entanglement is still a challenge with linear optics. In this paper, a multiphoton GHZ state with arbitrary dimensions preparation protocol is proposed in optical systems. In this protocol, we use auxiliary entanglements to realize a high-dimensional entanglement gate, so that high-dimensional entangled pairs can be connected into a multipartite high-dimensional GHZ state. Specifically, we give an example of using photons' path degree of freedom to prepare a 4-particle 3-dimensional GHZ state. Our method can be extended to other degrees of freedom and can generate arbitrary GHZ entanglement in any dimension.Comment: 8 pages, 2 figure