Anisotropic superconducting properties of aligned Sm0.95_{0.95}La0.05_{0.05}FeAsO0.85_{0.85}F0.15_{0.15} microcrystalline powder

The Sm$_{0.95}$La$_{0.05}$FeAsO$_{0.85}$F$_{0.15}$ compound is a quasi-2D layered superconductor with a superconducting transition temperature T$_c$ = 52 K. Due to the Fe spin-orbital related anisotropic exchange coupling (antiferromagnetic or ferromagnetic fluctuation), the tetragonal microcrystalline powder can be aligned at room temperature using the field-rotation method where the tetragonal $\it{ab}$-plane is parallel to the aligned magnetic field B$_{a}$ and $\it{c}$-axis along the rotation axis. Anisotropic superconducting properties with anisotropic diamagnetic ratio $\chi_{c}/\chi_{ab}\sim$ 2.4 + 0.6 was observed from low field susceptibility $\chi$(T) and magnetization M(B$_{a}$). The anisotropic low-field phase diagram with the variation of lower critical field gives a zero-temperature penetration depth $\lambda_{c}$(0) = 280 nm and $\lambda_{ab}$(0) = 120 nm. The magnetic fluctuation used for powder alignment at 300 K may be related with the pairing mechanism of superconductivity at lower temperature.Comment: 4 pages, 6 figure

Thermal and electrical study on ac light-emitting diode with quantum wells under various cooling rate

Paper presented to the 10th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Florida, 14-16 July 2014.The conventional Shockley equation is inappropriate to describe the relationship between the current density and the forward voltage drop across the p-n junction in LED (light-emitting diode) with multiple quantum wells. In the present study, a semi-empirical model based on the existing experimental measurements is proposed to evaluate the forwards voltage drop under given current density and temperature. The numerical model then is employed to investigate the electrical and temperature fields on ac LED with multiple quantum wells under various cooling rate. The numerical results reveal that the temperature of the LED oscillates under ac electrical potential. The temperature increases due to the heat generation arising from the electrical current across the p-n junction when the electrical potential exceeds the threshold voltage. Otherwise, there is no electrical current and thus the temperature decreases due to the effect of the cooling device. Both light-emitting power and maximum temperature increase as expected when the applied ac electrical potential increases. Fortunately, the temperature of the LED can be efficiently controlled by increasing the cooling rate. Although increasing the cooling rate would decrease the light-emitting power, the influence is not significant.cf201

Applications of simulation technique on debris-flow hazard zone delineation: a case study in Hualien County, Taiwan

Debris flows pose severe hazards to communities in mountainous areas, often resulting in the loss of life and property. Helping debris-flow-prone communities delineate potential hazard zones provides local authorities with useful information for developing emergency plans and disaster management policies. In 2003, the Soil and Water Conservation Bureau of Taiwan proposed an empirical model to delineate hazard zones for all creeks (1420 in total) with potential of debris flows and utilized the model to help establish a hazard prevention system. However, the model does not fully consider hydrologic and physiographical conditions for a given creek in simulation. The objective of this study is to propose new approaches that can improve hazard zone delineation accuracy and simulate hazard zones in response to different rainfall intensity. In this study, a two-dimensional commercial model FLO-2D, physically based and taking into account the momentum and energy conservation of flow, was used to simulate debris-flow inundated areas. <br><br> Sensitivity analysis with the model was conducted to determine the main influence parameters which affect debris flow simulation. Results indicate that the roughness coefficient, yield stress and volumetric sediment concentration dominate the computed results. To improve accuracy of the model, the study examined the performance of the rainfall-runoff model of FLO-2D as compared with that of the HSPF (Hydrological Simulation Program Fortran) model, and then the proper values of the significant parameters were evaluated through the calibration process. Results reveal that the HSPF model has a better performance than the FLO-2D model at peak flow and flow recession period, and the volumetric sediment concentration and yield stress can be estimated by the channel slope. The validation of the model for simulating debris-flow hazard zones has been confirmed by a comparison of field evidence from historical debris-flow disaster data. The model can successfully replicate the influence zone of the debris-flow disaster event with an acceptable error and demonstrate a better result than the empirical model adopted by the Soil and Water Conservation Bureau of Taiwan

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Amyloid-β peptide (Aβ) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration. We have recently demonstrated that Aβ induced oligodendrocyte (OLG) apoptosis, suggesting a role in white matter pathology in AD. Here, we explore the molecular mechanisms involved in Aβ-induced OLG death, examining the potential role of ceramide, a known apoptogenic mediator. Both Aβ and ceramide induced OLG death. In addition, Aβ activated neutral sphingomyelinase (nSMase), but not acidic sphingomyelinase, resulting in increased ceramide generation. Blocking ceramide degradation with N-oleoyl-ethanolamine exacerbated Aβ cytotoxicity; and addition of bacterial sphingomyelinase (mimicking cellular nSMase activity) induced OLG death. Furthermore, nSMase inhibition by 3-O-methyl-sphingomyelin or by gene knockdown using antisense oligonucleotides attenuated Aβ-induced OLG death. Glutathione (GSH) precursors inhibited Aβ activation of nSMase and prevented OLG death, whereas GSH depletors increased nSMase activity and Aβ-induced death. These results suggest that Aβ induces OLG death by activating the nSMase–ceramide cascade via an oxidative mechanism

Angular Dependence of X-ray Absorption Spectrum for Field-aligned Fe-based Superconductors

Anisotropic Fe K-edge and As K-edge X-ray absorption near edge spectrum (XANES) measurements on superconducting (T_c = 52 K) (Sm_{0.95}La_{0.05})FeAs(O_{0.85}F_{0.15}) field-aligned microcrystalline powder are presented. The angular dependence of Fe pre-edge peak (dipole transition of Fe-1s electrons to Fe-3d/As-4p hybrid bands) relative to the tetragonal ab-plane of aligned powder indicates larger density of state (DOS) along the c-axis, and is consistent with the LDA band structure calculation. The anisotropic Fe K-edge spectra exhibit a chemical shift to lower energy compared to FeO which are closely related to the itinerant character of Fe^{2+}-3d^6 orbitals. The anisotropic As K-edge spectra are more or less the mirror images of Fe K-edge due to the symmetrical Fe-As hybridiztion in the FeAs layer. Angular dependence of As main peak (dipole transition of As-1s electrons to higher energy hybrid bands) was observed suggesting character of As-4d e_g orbitals.Comment: 4 pages, 6 figures, accepted 9/11/2009 Physical Review B (B15

Dentin Sialophosphoprotein (DSPP) Gene-Silencing Inhibits Key Tumorigenic Activities in Human Oral Cancer Cell Line, OSC2

We determined recently that dentin sialophosphoprotein (DSPP), a member of the SIBLING (Small integrin-binding ligand N-linked glycoproteins) family of phosphoglycoproteins, is highly upregulated in human oral squamous cell carcinomas (OSCCs) where upregulation is associated with tumor aggressiveness. To investigate the effects of DSPP-silencing on the tumorigenic profiles of the oral cancer cell line, OSC2, short-hairpin RNA (shRNA) interference was employed to silence DSPP in OSC2 cells.Multiple regions of DSPP transcript were targeted for shRNA interference using hDSP-shRNA lentiviral particles designed to silence DSPP gene expression. Control shRNA plasmid encoding a scrambled sequence incapable of degrading any known cellular mRNA was used for negative control. Following puromycin selection of stable lines of DSSP-silenced OSC2 cells, phenotypic hallmarks of oral carcinogenesis were assayed by western blot and RT-PCR analyses, MTT (cell-viability), colony-formation, modified Boyden-Chamber (migration and invasion), and flow cytometry (cell-cycle and apoptosis) analyses. DSPP-silenced OSC2 cells showed altered cell morphology, reduced viability, decreased colony-formation ability, decreased migration and invasion, G0/G1 cell-cycle arrest, and increased tumor cell sensitivity to cisplatin-induced apoptosis. Furthermore, MMP-2, MMP-3, MMP-9, VEGF, Ki-67, p53, and EGFR were down-regulated. There was a direct correlation between the degree of DSPP-silencing and MMP suppression, as indicated by least squares regression: MMP-2 {(y = 0.850x, p<0.001) (y = 1.156x, p<0.001)}, MMP-3 {(y = 0.994x, p<0.001) (y = 1.324x, p = 0.004)}, and MMP-9 {(y = 1.248x, p = 0.005, y = 0.809, p = 0.013)}.DSPP-silencing in OSC2 cell decreased salient hallmarks of oral tumorigenesis and provides the first functional evidence of a potential key role for DSPP in oral cancer biology. The down-regulation of MMP-2, MMP-3, MMP-9, p53 and VEGF in DSPP-silenced OSC2 cells provides a significant functional/molecular framework for deciphering the mechanisms of DSPP activities in oral cancer biology

Realization of the farad from the dc quantum Hall effect with digitally-assisted impedance bridges

A new traceability chain for the derivation of the farad from dc quantum Hall effect has been implemented at INRIM. Main components of the chain are two new coaxial transformer bridges: a resistance ratio bridge, and a quadrature bridge, both operating at 1541 Hz. The bridges are energized and controlled with a polyphase direct-digital-synthesizer, which permits to achieve both main and auxiliary equilibria in an automated way; the bridges and do not include any variable inductive divider or variable impedance box. The relative uncertainty in the realization of the farad, at the level of 1000 pF, is estimated to be 64E-9. A first verification of the realization is given by a comparison with the maintained national capacitance standard, where an agreement between measurements within their relative combined uncertainty of 420E-9 is obtained.Comment: 15 pages, 11 figures, 3 table