The Role of Organizational Buy-in in Employee Retention

This study examined the role of organizational buy-in, the acceptance and willingness to actively support and participate in the organizations plans, in the relationship between job satisfaction and intent to stay. Furthermore, this study proposed that job position would moderate the influence of organizational buy-in, as those in higher positions may be more invested in the organiation’s strategy. Two models were tested – a moderated moderation model, and a double moderated model. Support was found for the double moderated model. Organizational buy-in acted as a buffer between job satisfaction and intent to stay, such that those who have low job satisfaction but high organizational buy-in have a higher intent to stay than those with low job satisfaction and low organizational buy-in. Alternatively, position amplified the relationship between job satisfaction and intent to stay. When job satisfaction is low, those in higher job positions have a lower intent to stay than those in lower job positions. Implications and future research are discussed. This study bridges the gap between industrial organizational research and business strategy by examining how attitudes about the strategy influences the behavior of those charged with executing it. It combines one of the oldest relationships in HR management literature, job satisfaction and attrition risk, with one of the newest areas of research in organizational behavior literature, organizational strategy. Findings suggest that an employee’s buy-in to the organization’s mission and strategy influences their attrition risk and a strong strategy can be a competitive advantage for retaining talent

RNA interference of gonadotropin-inhibitory hormone gene induces arousal in songbirds.

Gonadotropin-inhibitory hormone (GnIH) was originally identified in quail as a hypothalamic neuropeptide inhibitor of pituitary gonadotropin synthesis and release. However, GnIH neuronal fibers do not only terminate in the median eminence to control anterior pituitary function but also extend widely in the brain, suggesting it has multiple roles in the regulation of behavior. To identify the role of GnIH neurons in the regulation of behavior, we investigated the effect of RNA interference (RNAi) of the GnIH gene on the behavior of white-crowned sparrows, a highly social songbird species. Administration of small interfering RNA against GnIH precursor mRNA into the third ventricle of male and female birds reduced resting time, spontaneous production of complex vocalizations, and stimulated brief agonistic vocalizations. GnIH RNAi further enhanced song production of short duration in male birds when they were challenged by playbacks of novel male songs. These behaviors resembled those of breeding birds during territorial defense. The overall results suggest that GnIH gene silencing induces arousal. In addition, the activities of male and female birds were negatively correlated with GnIH mRNA expression in the paraventricular nucleus. Density of GnIH neuronal fibers in the ventral tegmental area was decreased by GnIH RNAi treatment in female birds, and the number of gonadotropin-releasing hormone neurons that received close appositions of GnIH neuronal fiber terminals was negatively correlated with the activity of male birds. In summary, GnIH may decrease arousal level resulting in the inhibition of specific motivated behavior such as in reproductive contexts

A Qualitative Evaluation of the 4-H Record Book in Light of the PYD Concepts: Belonging, Mastery, Independence, and Generosity

The highlights of a study of the 4-H Record Book (RB) in light of the four positive youth development (PYD) concepts: belonging, mastery, independence, and generosity are discussed in this paper. Utilizing qualitative methods we interviewed 21 participants (14 leaders, 9 recent 4-H alumni) from 9 states. Results describe the ways in which participants perceived that the RB (a) supports the four PYD concepts (e.g., “RB fosters independence through the goal setting, monitoring, and appraising process”) and (b) does not support, or should be revised to support the concept (e.g., “RB competitions may hinder mastery”). Our results support the RB as a PYD intervention but we recommend that states/counties consider these results when revising RBs. In light of concerns about age and developmental appropriateness, we suggest that the most pressing question is whether or not the traditionally formatted RB is appropriate for all 4-Hers. We encourage RB committees to engage professionals with developmental expertise (e.g., educators) in RB revisions

BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Background: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. Methods: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. Findings: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52–1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03–4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [<1%], adjusted OR 5·58 [1·22–25·50]; p=0·024). Interpretation: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. Funding: None

A Qualitative Evaluation of the 4-H Record Book in Light of the PYD Concepts: Belonging, Mastery, Independence, and Generosity

The highlights of a study of the 4-H Record Book (RB) in light of the four positive youth development (PYD) concepts: belonging, mastery, independence, and generosity are discussed in this paper. Utilizing qualitative methods we interviewed 21 participants (14 leaders, 9 recent 4-H alumni) from 9 states. Results describe the ways in which participants perceived that the RB (a) supports the four PYD concepts (e.g., “RB fosters independence through the goal setting, monitoring, and appraising process”) and (b) does not support, or should be revised to support the concept (e.g., “RB competitions may hinder mastery”). Our results support the RB as a PYD intervention but we recommend that states/counties consider these results when revising RBs. In light of concerns about age and developmental appropriateness, we suggest that the most pressing question is whether or not the traditionally formatted RB is appropriate for all 4-Hers. We encourage RB committees to engage professionals with developmental expertise (e.g., educators) in RB revisions

Fluid-Attenuated Inversion Recovery Hyperintense Ischemic Stroke Predicts Less Favorable 90-Day Outcome after Intravenous Thrombolysis.

INTRODUCTION: The absence of an ischemic lesion on MRI fluid-attenuated inversion recovery (FLAIR) is helpful in predicting stroke onset within 4.5 h. However, some ischemic strokes become visible on FLAIR within 4.5 h. We hypothesized that the early lesion visibility on FLAIR may predict stroke outcome 90 days after intravenous (IV) thrombolysis, independent of time. MATERIALS AND METHODS: We analyzed data from acute ischemic stroke patients presenting over the last 10 years who were screened with MRI and treated with IV thrombolysis within 4.5 h from onset. Three independent readers assessed whether ischemic lesions seen on diffusion-weighted imaging were also FLAIR positive based on visual inspection. Multivariable regression analyses were used to obtain an adjusted odds ratio of favorable clinical and radiological outcomes based on FLAIR positivity. RESULTS: Of 297 ischemic stroke patients, 25% had lesion visibility on initial FLAIR. The interrater agreement for the FLAIR positivity assessment was 84% (κ = 0.604, 95% CI: 0.557-0.652). Patients with FLAIR-positive lesions had more right hemispheric strokes (57 vs. 41%, p = 0.045), were imaged later (129 vs. 104 min, p = 0.036), and had less frequent favorable 90-day functional outcome (49 vs. 63%, p = 0.028), less frequent early neurologic improvement (30 vs. 58%, p = 0.001), and more frequent contrast extravasation to the cerebrospinal fluid space (44 vs. 26%, p = 0.008). CONCLUSIONS: Early development of stroke lesion on FLAIR within 4.5 h of onset is associated with reduced likelihood of favorable 90-day outcome after IV thrombolysis

Effect of GnIH RNAi on the activity of white-crowned sparrows.

<p>Spontaneous resting time of control male (SCM), experimental male (SEM), control female (SCF), and experimental female (SEF) birds in 10 minutes; and the resting time of control male (PCM), experimental male (PEM), control female (PCF), and experimental female (PEF) birds in 10 minutes averaged from their responses to four male song playbacks. The columns and the vertical lines represent the mean ± SEM (n = 8). ***, <i>P</i><0.001 vs SCM, ††, <i>P</i><0.01 vs SCF by one-way ANOVA followed by Fisher’s PLSD.</p

Effect of GnIH RNAi on GnIH precursor mRNA and GnIH expression.

<p><b><i>A,</i></b> Expression of GnIH precursor mRNA positive cells in the paraventricular nucleus of control male (a, CM), control female (b, CF), experimental male (c, EM), and experimental female (d, EF). Bar = 50 µm. <b><i>B,</i></b> The product of the cell number and the mean density of <i>in situ</i> hybridization signal from three most populated sections containing GnIH precursor mRNA positive cells in CM, EM, CF, and EF bird brain. The columns and the vertical lines represent the mean ± SEM (n = 8). *, <i>P</i><0.05 CM vs EM, CF vs EF by two-tailed Student’s <i>t</i>-test. <b><i>C,</i></b> Effect of GnIH RNAi on GnIH concentration in the diencephalon. GnIH concentration in the diencephalon was significantly reduced in GnIH siRNA administered birds (GnIH RNAi, n = 7) compared to vehicle (n = 4) and control RNA (n = 5) administered birds. The columns and the vertical lines represent the mean ± SEM. *, <i>P</i><0.05 vehicle or control vs. GnIH RNAi by one-way ANOVA followed by Fisher’s PLSD.</p

Relationships between the resting time and the GnIH neuronal system.

<p><b><i>A</i></b>, Relationship between the resting time and GnIH mRNA level in the PVN of male birds. Closed circles indicate the results of control birds, whereas open circles indicate the results of experimental birds. N = 15, R = 0.51, *, <i>P</i><0.05 by two-sided Pearson’s correlation test. <b><i>B</i></b>, Relationship between the resting time and GnIH mRNA level in the PVN of female birds. N = 15, R = 0.63, *, <i>P</i><0.05 by two-sided Pearson’s correlation test. <b><i>C</i></b>, Relationship between the resting time and the number of GnRH-I neurons with close appositions of GnIH-ir neuronal fiber terminal like structures in male birds. N = 15, R = 0.78, ***, <i>P</i><0.001 by two-sided Pearson’s correlation test. <b><i>D</i></b>, Relationship between the resting time and the number of GnRH-II neurons with close appositions of GnIH-ir neuronal fiber terminal like structures in male birds. N = 15, R = 0.55, *, <i>P</i><0.05 by two-sided Pearson’s correlation test.</p