De Sitter ground state of scalar-tensor gravity and its primordial perturbation

Scalar-tensor gravity is one of the most competitive gravity theory to Einstein's relativity. We reconstruct the exact de Sitter solution in scalar-tensor gravity, in which the non-minimal coupling scalar is rolling along the potential. This solution may have some relation to the early inflation and present acceleration of the universe. We investigated its primordial quantum perturbation around the adiabatic vacuum. We put forward for the first time that exact de Sitter generates non-exactly scale invariant perturbations. In the conformal coupling case, this model predicts that the tensor mode of the perturbation (gravity wave) is strongly depressed.Comment: 9 page

Variable Modified Chaplygin Gas in Anisotropic Universe with Kaluza-Klein Metric

In this work, we have consider Kaluza-Klein Cosmology for anisotropic universe where the universe is filled with variable modified chaplygin gas (VMCG). Here we find normal scalar field $\phi$ and the self interacting potential $V(\phi)$ to describe the VMCG Cosmology. Also we graphically analyzed the geometrical parameters named {\it statefinder parameters} in anisotropic Kaluza-Klein model. Next, we consider a Kaluza-Klein model of interacting VMCG with dark matter in the Einstein gravity framework. Here we construct the three dimensional autonomous dynamical system of equations for this interacting model with the assumption that the dark energy and the dark matter are interact between them and for that we also choose the interaction term. We convert that interaction terms to its dimensionless form and perform stability analysis and solve them numerically. We obtain a stable scaling solution of the equations in Kaluza-Klein model and graphically represent solutions.Comment: 11 pages, 13 figure

Inter-generational transmission in a minority language setting: Stop consonant production by Bangladeshi heritage children and adults

Aims and objectives: The purpose of this study was to gain a better understanding of speech development across successive generations of heritage language users, examining how cross-linguistic, developmental and socio-cultural factors affect stop consonant production. Design: To this end, we recorded Sylheti and English stop productions of two sets of Bangladeshi heritage families: (1) first-generation adult migrants from Bangladesh and their (second-generation) UK-born children, and (2) second-generation UK-born adult heritage language users and their (third-generation) UK-born children. Data and analysis: The data were analysed auditorily, using whole-word transcription, and acoustically, examining voice onset time. Comparisons were then made in both languages across the four groups of participants, and cross-linguistically. Findings: The results revealed non-native productions of English stops by the first-generation migrants but largely target-like patterns by the remaining sets of participants. The Sylheti stops exhibited incremental changes across successive generations of speakers, with the third-generation children’s productions showing the greatest influence from English. Originality: This is one of few studies to examine both the host and heritage language in an ethnic minority setting, and the first to demonstrate substantial differences in heritage language accent between age-matched second- and third-generation children. The study shows that current theories of bilingual speech learning do not go far enough in explaining how speech develops in heritage language settings. Implications: These findings have important implications for the maintenance, transmission and long-term survival of heritage languages, and show that investigations need to go beyond second-generation speakers, in particular in communities that do not see a steady influx of new migrants

UV stable, Lorentz-violating dark energy with transient phantom era

Phantom fields with negative kinetic energy are often plagued by the vacuum quantum instability in the ultraviolet region. We present a Lorentz-violating dark energy model free from this problem and show that the crossing of the cosmological constant boundary w=-1 to the phantom equation of state is realized before reaching a de Sitter attractor. Another interesting feature is a peculiar time-dependence of the effective Newton's constant; the magnitude of this effect is naturally small but may be close to experimental limits. We also derive momentum scales of instabilities at which tachyons or ghosts appear in the infrared region around the present Hubble scale and clarify the conditions under which tachyonic instabilities do not spoil homogeneity of the present/future Universe.Comment: 22 pages, 7 figures; Presentation modified substantially, results and conclusions unchanged. Journal versio

Exhaustive Sampling of Docking Poses Reveals Binding Hypotheses for Propafenone Type Inhibitors of P-Glycoprotein

Overexpression of the xenotoxin transporter P-glycoprotein (P-gp) represents one major reason for the development of multidrug resistance (MDR), leading to the failure of antibiotic and cancer therapies. Inhibitors of P-gp have thus been advocated as promising candidates for overcoming the problem of MDR. However, due to lack of a high-resolution structure the concrete mode of interaction of both substrates and inhibitors is still not known. Therefore, structure-based design studies have to rely on protein homology models. In order to identify binding hypotheses for propafenone-type P-gp inhibitors, five different propafenone derivatives with known structure-activity relationship (SAR) pattern were docked into homology models of the apo and the nucleotide-bound conformation of the transporter. To circumvent the uncertainty of scoring functions, we exhaustively sampled the pose space and analyzed the poses by combining information retrieved from SAR studies with common scaffold clustering. The results suggest propafenone binding at the transmembrane helices 5, 6, 7 and 8 in both models, with the amino acid residue Y307 playing a crucial role. The identified binding site in the non-energized state is overlapping with, but not identical to, known binding areas of cyclic P-gp inhibitors and verapamil. These findings support the idea of several small binding sites forming one large binding cavity. Furthermore, the binding hypotheses for both catalytic states were analyzed and showed only small differences in their protein-ligand interaction fingerprints, which indicates only small movements of the ligand during the catalytic cycle

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others