Design of a partial peptide mimetic of anginex with antiangiogenic and anticancer activity

Based on structure-activity relationships of the angiostatic ß-sheet-forming peptide anginex, we have designed a mimetic, 6DBF7, which inhibits angiogenesis and tumor growth in mice. 6DBF7 is composed of a ß-sheet-inducing dibenzofuran (DBF)-turn mimetic and two short key amino acid sequences from anginex. This novel antiangiogenic molecule is more effective in vivo than parent anginex. In a mouse xenograft model for ovarian carcinoma, 6DBF7 is observed to reduce tumor growth by up to 80%. It is suggested that the activity is based on antiangiogenesis, because in vitro tube formation is inhibited, and because treatment of tumor-bearing mice led to a significant reduction in microvessel density within the tumor. This partial peptide mimetic is the first endothelial cell-specific molecule designed as a substitute for an angiostatic inhibitory peptide

Design of a partial peptide mimetic of anginex with antiangiogenic and anticancer activity

Based on structure-activity relationships of the angiostatic ß-sheet-forming peptide anginex, we have designed a mimetic, 6DBF7, which inhibits angiogenesis and tumor growth in mice. 6DBF7 is composed of a ß-sheet-inducing dibenzofuran (DBF)-turn mimetic and two short key amino acid sequences from anginex. This novel antiangiogenic molecule is more effective in vivo than parent anginex. In a mouse xenograft model for ovarian carcinoma, 6DBF7 is observed to reduce tumor growth by up to 80%. It is suggested that the activity is based on antiangiogenesis, because in vitro tube formation is inhibited, and because treatment of tumor-bearing mice led to a significant reduction in microvessel density within the tumor. This partial peptide mimetic is the first endothelial cell-specific molecule designed as a substitute for an angiostatic inhibitory peptide

Incidence of Fusarium verticillioides and levels of fumonisin B1 and B2 in corn in Turkey

A total of 100 corn samples conforming collected from local farmers and markets from districts of Samsun, Turkey, were analyzed for Fusarium fumonisin B-1 and B-2 contamination. Ninety-three corn samples were found to contain F. verticillioides, 52 samples fumonisin B-1, and 25 samples fumonisin B-2. Fumonisin B-1 contamination ranged from 0.05 to 25.72 mg/kg and B-2 from 0.05 to 5.7 mg/kg, respectively. This figure indicated widespread contamination of fumonisin B-1 and B-2 in maize grown in different areas of Samsun, Turkey