2,269 research outputs found
Maine State Archives 2018 2nd Quarter Acquisitions Report
https://digitalmaine.com/shared_acquisitions/1005/thumbnail.jp
Maine State Archives 2018 1st Quarter Acquisitions Report
https://digitalmaine.com/shared_acquisitions/1000/thumbnail.jp
Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats
BACKGROUND: Animals must frequently make choices between alternative courses of action, seeking to maximize the benefit obtained. They must therefore evaluate the magnitude and the likelihood of the available outcomes. Little is known of the neural basis of this process, or what might predispose individuals to be overly conservative or to take risks excessively (avoiding or preferring uncertainty, respectively). The nucleus accumbens core (AcbC) is known to contribute to rats' ability to choose large, delayed rewards over small, immediate rewards; AcbC lesions cause impulsive choice and an impairment in learning with delayed reinforcement. However, it is not known how the AcbC contributes to choice involving probabilistic reinforcement, such as between a large, uncertain reward and a small, certain reward. We examined the effects of excitotoxic lesions of the AcbC on probabilistic choice in rats. RESULTS: Rats chose between a single food pellet delivered with certainty (p = 1) and four food pellets delivered with varying degrees of uncertainty (p = 1, 0.5, 0.25, 0.125, and 0.0625) in a discrete-trial task, with the large-reinforcer probability decreasing or increasing across the session. Subjects were trained on this task and then received excitotoxic or sham lesions of the AcbC before being retested. After a transient period during which AcbC-lesioned rats exhibited relative indifference between the two alternatives compared to controls, AcbC-lesioned rats came to exhibit risk-averse choice, choosing the large reinforcer less often than controls when it was uncertain, to the extent that they obtained less food as a result. Rats behaved as if indifferent between a single certain pellet and four pellets at p = 0.32 (sham-operated) or at p = 0.70 (AcbC-lesioned) by the end of testing. When the probabilities did not vary across the session, AcbC-lesioned rats and controls strongly preferred the large reinforcer when it was certain, and strongly preferred the small reinforcer when the large reinforcer was very unlikely (p = 0.0625), with no differences between AcbC-lesioned and sham-operated groups. CONCLUSION: These results support the view that the AcbC contributes to action selection by promoting the choice of uncertain, as well as delayed, reinforcement
Solid transport in a pyrolysis pilot-scale rotary kiln: preliminary results - stationary and dynamic results
4th International Conference on Conveying and Handling of Particulate Solids, Budapest, HUNGARY, MAY 27-30, 2003International audienceExperiments for the investigation of the flow of granular solids in a pyrolysis pilot-scale rotary kiln are presented. These experiments consisted first in measuring the volumetric filling ratio (steady-state experiences) for several operating conditions and second in recording the exit flow rates after a positive or negative step in one of the operating parameters (dynamic experiences). A dynamical model computing the evolution of the flow rate of granular solids through the kiln has been developed based on Saeman model [Chem. Eng. Prog. 47 (1951) 508]. The simulations are compared with experimental results; the model gives good results for the rolling mode, but for the slipping mode too
Transforming Nanomaterial Synthesis with Flow Chemistry
Microfluidic methods for the synthesis of nanomaterials allow the generation of high-quality products with outstanding structural, electronic and optical properties. At a fundamental level, this is engendered by the ability to control both heat and mass transfer in a rapid and precise manner, but also by the facile integration of in-line characterization tools and machine learning algorithms. Such integrated platforms provide for exquisite control over material properties during synthesis, accelerate the optimization of electronic and optical properties and bestow new insights into the optoelectronic properties of nanomaterials. Herein, we present a brief perspec-tive on the role that microfluidic technologies can play in nanomaterial synthesis, with a particular focus on recent studies that incorporate in-line optical characterization and machine learning. We also consider the importance and challenges associated with integrating additional functional components within experimental workflows and the upscaling of microfluidic platforms for production of industrial-scale quantities of nanomaterials
Assessing the quality of written information provision for surgical procedures:A case study in oesophagectomy
OBJECTIVE: To examine the content and quality of written information provided by surgical centres for patients undergoing oesophagectomy for cancer. DESIGN: Cross-sectional study of the content of National Health Service (NHS) patient information leaflets (PILs) about oesophageal cancer surgery, using a modified framework approach. DATA SOURCES: Written information leaflets from 41 of 43 cancer centres undertaking surgery for oesophageal cancer in England and Wales (response rate 95.3%). ELIGIBILITY CRITERIA: All English language versions of PILs about oesophagectomy. RESULTS: 32 different PILs were identified, of which 2 were generic tools (Macmillan ‘understanding cancer of the gullet’ and EIDO ‘oesophagectomy’). Although most PILs focused on describing in-hospital adverse events, information varied widely and was often misleading. Just 1 leaflet described survival benefits of surgery and 2 mentioned the possibility of disease recurrence. CONCLUSIONS: Written information provided for patients by NHS cancer centres undertaking oesophagectomy is inconsistent and incomplete. It is recommended that surgeons work together with patients to agree on standards of information provision of relevance to all stakeholders’ needs
Astrophysical Gyrokinetics: Basic Equations and Linear Theory
Magnetohydrodynamic (MHD) turbulence is encountered in a wide variety of
astrophysical plasmas, including accretion disks, the solar wind, and the
interstellar and intracluster medium. On small scales, this turbulence is often
expected to consist of highly anisotropic fluctuations with frequencies small
compared to the ion cyclotron frequency. For a number of applications, the
small scales are also collisionless, so a kinetic treatment of the turbulence
is necessary. We show that this anisotropic turbulence is well described by a
low frequency expansion of the kinetic theory called gyrokinetics. This paper
is the first in a series to examine turbulent astrophysical plasmas in the
gyrokinetic limit. We derive and explain the nonlinear gyrokinetic equations
and explore the linear properties of gyrokinetics as a prelude to nonlinear
simulations. The linear dispersion relation for gyrokinetics is obtained and
its solutions are compared to those of hot-plasma kinetic theory. These results
are used to validate the performance of the gyrokinetic simulation code {\tt
GS2} in the parameter regimes relevant for astrophysical plasmas. New results
on global energy conservation in gyrokinetics are also derived. We briefly
outline several of the problems to be addressed by future nonlinear
simulations, including particle heating by turbulence in hot accretion flows
and in the solar wind, the magnetic and electric field power spectra in the
solar wind, and the origin of small-scale density fluctuations in the
interstellar medium.Comment: emulateapj, 24 pages, 10 figures, revised submission to ApJ:
references added, typos corrected, reorganized and streamline
Population of neutron unbound states via two-proton knockout reactions
The two-proton knockout reaction 9Be(26Ne,O2p) was used to explore excited
unbound states of 23O and 24O. In 23O a state at an excitation energy of
2.79(13) MeV was observed. There was no conclusive evidence for the population
of excited states in 24O.Comment: 6 pages, 3 figures, Proc. 9th Int. Spring Seminar on Nucl. Phys.
Changing Facets of Nuclear Structure, May 20-34, 200
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