The social shaping of packaged software selection

As organisations increasingly engage in the selection, purchase, and adoption of packaged software products, howthese activities are carried out in practice becomes increasingly relevant for researchers and practitioners. Ourfocus in this paper is to propose a framework for understanding the packaged software selection process. Thefunctionalist literature on this area of study suggests a number of generic recommendations, which are based onrational assumptions about the process and view the decision making that takes place as producing the “besttechnology solution.’” To explore this, we conducted a longitudinal, in-depth study of packaged software selectionin a small organisation. For interpretation of the case, we draw upon the Social Construction of Technology, atheoretical framework arguing that technology is socially constituted and regarding the process of development ascontradictory and uncertain. We offer a number of contributions. First, we further our understanding of packagedsoftware selection with the critique that we offer of the functionalist literature, drawing insights from the emergingcritical/constructivist literature and expanding our domain of interest to encompass the wider environment. Second,we weave this together with our experiences in the field, drawing on social constructivism for theoretical support, todevelop a framework of packaged software selection that shows how various actors shape the process

Pengembangan Media Pembelajaran Virtual dan Interaktif untuk Mensimulasikan Instalasi Jaringan Listrik di SMK 2 Surakarta

Pembelajaran instalasi listrik di SMK sering menjadi masalah karena harus tersedianya peralatan yang harus selalu membeli perangkat nyata namun setelah itu perangkat yang digunakan untuk pembelajaran tidak digunakan kembali dan juga yang penting adalah ternyata cara pembelajaran seperti ini kurang efektif karena biasanya dilakukan secara berkelompok. Pada saat pembelajaran dilakukan secara berkelompok maka ada siswa yang hanya mengandalkan hasil kerja rekan-rekannya dan ada yang tidak memperhatikan terhadap pelajaran yang diberikan akhirnya tidak menerima manfaat dari pembelajaran tersebut. Untuk itu dikembangkan sebuah media interaktif yang ditujukan untuk mensimulasikan rangkaian listrik sederhana sehingga bisa dicoba secara langsung oleh masing-masing siswa secara menarik dan interaktif sehingga setiap siswa akan menjadi senang belajar instalasi listrik dan mendapat manfaat serta bisa menyerap materi yang diinginkan

Critical Reading Across the Engineering Disciplines

Engineering students spend a significant amount of time discovering, evaluating, and reading/interpreting information. This book chapter discusses the existing knowledge around undergraduate engineering student information and critical reading practices and presents a case study that provides a successful pedagogical strategy to address these salient issues in the classroom

Observation of Muon Neutrino Disappearance with the MINOS Detectors in the NuMI Neutrino Beam

This Letter reports results from the MINOS experiment based on its initial exposure to neutrinos from the Fermilab NuMI beam. The rates and energy spectra of charged current ν_μ interactions are compared in two detectors located along the beam axis at distances of 1 and 735 km. With 1.27×10^(20) 120 GeV protons incident on the NuMI target, 215 events with energies below 30 GeV are observed at the Far Detector, compared to an expectation of 336±14 events. The data are consistent with ν_μ disappearance via oscillations with Δm_(32)^2|=2.74_(-0.26)^(+0.44)×10^(-3)  eV^2 and sin^2(2θ_(23))>0.87 (68% C.L.)

First observations of separated atmospheric ν_μ and ν̅ _μ events in the MINOS detector

The complete 5.4 kton MINOS far detector has been taking data since the beginning of August 2003 at a depth of 2070 meters water-equivalent in the Soudan mine, Minnesota. This paper presents the first MINOS observations of ν_μ and ν̅ _μ charged-current atmospheric neutrino interactions based on an exposure of 418 days. The ratio of upward- to downward-going events in the data is compared to the Monte Carlo expectation in the absence of neutrino oscillations, giving R^(data)_(up/down/R^(MC)_(up/down) = 0:62^(+0.19)_(0:14)(stat.) ± 0.02(sys.). An extended maximum likelihood analysis of the observed L/E distributions excludes the null hypothesis of no neutrino oscillations at the 98% confidence level. Using the curvature of the observed muons in the 1.3 T MINOS magnetic field ν_μ and ν̅ _μ interactions are separated. The ratio of ν̅ _μ to ν_μ events in the data is compared to the Monte Carlo expectation assuming neutrinos and antineutrinos oscillate in the same manner, giving R^(data)_(ν_μ/ν̅ _μ) / R^(MC)_(ν_μ/ν̅ _μ) = 0.96^(+0:38)_(0.27)(stat.) ± 0.15(sys.), where the errors are the statistical and systematic uncertainties. Although the statistics are limited, this is the first direct observation of atmospheric neutrino interactions separately for ν_μ and ν̅ _μ

In Vivo Expression of MHC Class I Genes Depends on the Presence of a Downstream Barrier Element

Regulation of MHC class I gene expression is critical to achieve proper immune surveillance. In this work, we identify elements downstream of the MHC class I promoter that are necessary for appropriate in vivo regulation: a novel barrier element that protects the MHC class I gene from silencing and elements within the first two introns that contribute to tissue specific transcription. The barrier element is located in intergenic sequences 3′ to the polyA addition site. It is necessary for stable expression in vivo, but has no effect in transient transfection assays. Accordingly, in both transgenic mice and stably transfected cell lines, truncation of the barrier resulted in transcriptional gene silencing, increased nucleosomal density and decreased histone H3K9/K14 acetylation and H3K4 di-methylation across the gene. Significantly, distinct sequences within the barrier element govern anti-silencing and chromatin modifications. Thus, this novel barrier element functions to maintain transcriptionally permissive chromatin organization and prevent transcriptional silencing of the MHC class I gene, ensuring it is poised to respond to immune signaling

Three Novel Downstream Promoter Elements Regulate MHC Class I Promoter Activity in Mammalian Cells

BACKGROUND: MHC CLASS I TRANSCRIPTION IS REGULATED BY TWO DISTINCT TYPES OF REGULATORY PATHWAYS: 1) tissue-specific pathways that establish constitutive levels of expression within a given tissue and 2) dynamically modulated pathways that increase or decrease expression within that tissue in response to hormonal or cytokine mediated stimuli. These sets of pathways target distinct upstream regulatory elements, have distinct basal transcription factor requirements, and utilize discrete sets of transcription start sites within an extended core promoter. METHODOLOGY/PRINCIPAL FINDINGS: We studied regulatory elements within the MHC class I promoter by cellular transfection and in vitro transcription assays in HeLa, HeLa/CIITA, and tsBN462 of various promoter constructs. We have identified three novel MHC class I regulatory elements (GLE, DPE-L1 and DPE-L2), located downstream of the major transcription start sites, that contribute to the regulation of both constitutive and activated MHC class I expression. These elements located at the 3' end of the core promoter preferentially regulate the multiple transcription start sites clustered at the 5' end of the core promoter. CONCLUSIONS/SIGNIFICANCE: Three novel downstream elements (GLE, DPE-L1, DPE-L2), located between +1 and +32 bp, regulate both constitutive and activated MHC class I gene expression by selectively increasing usage of transcription start sites clustered at the 5' end of the core promoter upstream of +1 bp. Results indicate that the downstream elements preferentially regulate TAF1-dependent, relative to TAF1-independent, transcription

Search for the disappearance of muon antineutrinos in the NuMI neutrino beam

We report constraints on antineutrino oscillation parameters that were obtained by using the two MINOS detectors to measure the 7% muon antineutrino component of the NuMI neutrino beam. In the Far Detector, we select 130 events in the charged-current muon antineutrino sample, compared to a prediction of 136.4 ± 11.7(stat)^(+10.2)_(-8.9)(syst) events under the assumption │Δm^2│ = 2.32 X 10^(-3) eV^2, sin^2(2θ) = 1.0

A Study of Muon Neutrino Disappearance Using the Fermilab Main Injector Neutrino Beam

We report the results of a search for muon-neutrino disappearance by the Main Injector Neutrino Oscillation Search. The experiment uses two detectors separated by 734 km to observe a beam of neutrinos created by the Neutrinos at the Main Injector facility at Fermi National Accelerator Laboratory. The data were collected in the first 282 days of beam operations and correspond to an exposure of 1.27e20 protons on target. Based on measurements in the Near Detector, in the absence of neutrino oscillations we expected 336 +/- 14 muon-neutrino charged-current interactions at the Far Detector but observed 215. This deficit of events corresponds to a significance of 5.2 standard deviations. The deficit is energy dependent and is consistent with two-flavor neutrino oscillations according to delta m-squared = 2.74e-3 +0.44/-0.26e-3 eV^2 and sin^2(2 theta) > 0.87 at 68% confidence level.Comment: In submission to Phys. Rev.