Development of an Evolutionary Three-Dimensional Scroll Compressor

A novel three-dimensional scroll compressor was developed. The authors have produced 3D scroll compressor since 2004. The 3D scroll is able to compress refrigerant in axial direction as well as in existing radial direction by employing steps at the bottom and the tip of the scroll which change the height of compression chamber on the middle of the compression process. For the purpose of further performance improvement, the authors developed an evolutionary three-dimensional compression mechanism, named e-3D scroll . The e-3D scroll is equipped with a sloped tip and a sloped end plate in each scroll instead of the steps in the conventional 3D scroll. The height of compression chamber decreases continuously with progression of compression by the sloped shape. The e-3D scroll achieved considerable efficiency improvement compared to the conventional 3D scroll since there is no leakage loss in the steps while keeping the advantages of high compression ratio, large capacity and small size by the sloped tip and end plate. In addition, the noise and vibration of the e-3D scroll compressor reduced significantly since the rate of change of cylinder volume throughout the compression process and the torque variation in the rotation became smaller than the conventional 3D scroll. This article describes the compression mechanism and the performance improvement technology in the e-3D scroll

When Giant Language Brains Just Aren't Enough! Domain Pizzazz with Knowledge Sparkle Dust

Large language models (LLMs) have significantly advanced the field of natural language processing, with GPT models at the forefront. While their remarkable performance spans a range of tasks, adapting LLMs for real-world business scenarios still poses challenges warranting further investigation. This paper presents an empirical analysis aimed at bridging the gap in adapting LLMs to practical use cases. To do that, we select the question answering (QA) task of insurance as a case study due to its challenge of reasoning. Based on the task we design a new model relied on LLMs which are empowered by additional knowledge extracted from insurance policy rulebooks and DBpedia. The additional knowledge helps LLMs to understand new concepts of insurance for domain adaptation. Preliminary results on two QA datasets show that knowledge enhancement significantly improves the reasoning ability of GPT-3.5 (55.80% and 57.83% in terms of accuracy). The analysis also indicates that existing public knowledge bases, e.g., DBPedia is beneficial for knowledge enhancement. Our findings reveal that the inherent complexity of business scenarios often necessitates the incorporation of domain-specific knowledge and external resources for effective problem-solving.Comment: Ongoing work to adapt LLMs for business scenario

Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation

<p>Abstract</p> <p>Background</p> <p>Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknown, but is considered to be induced by either cell-cell fusion or acytokinetic cell division. Myxofibrosarcoma consists of spindled and pleomorphic tumor cells and bizarre multinucleated giant cells. Some of these multinucleated cells are considered to be neoplastic.</p> <p>Methods</p> <p>We studied the mitotic activity of the multinucleated cells by Ki-67 immunohistochemistry, and the dynamics and differentiation by live-cell video microscopy in the two myxofibrosarcoma cell lines to determine whether the mechanism of multinucleation is cell-cell fusion or acytokinetic cell division</p> <p>Results</p> <p>A Ki-67 immunohistochemical analysis revealed a high positive rate of multinucleated cells, as well as mononuclear cells, and mitotic ability was shown in the multinucleated cells. In live-cell video microscopy, most of the multinucleated cells were induced via the process of acytokinetic cell division.</p> <p>Conclusion</p> <p>The current study indicates that a vulnerability of the cytoskeleton components, such as the contractile ring, causes multinucleation to occur from the telophase to the cytokinesis of the cell cycle.</p

Analysis of T-cell alloantigen response via a direct pathway in kidney transplant recipients with donor-specific antibodies

Donor-specific antibodies (DSAs) are the main cause of graft loss over time. The direct pathway of alloantigen recognition is important in the pathogenesis of acute rejection. Recent studies have suggested that the direct pathway also contributes to the pathogenesis of chronic injury. Nevertheless, there are no reports on T-cell alloantigen response via the direct pathway in kidney recipients with DSAs. We analyzed the T-cell alloantigen response via the direct pathway in kidney recipients with DSAs (DSA+) or without DSAs (DSA−). A mixed lymphocyte reaction assay was implemented to assess the direct pathway response. DSA+ patients showed significantly higher CD8+ and CD4+ T cell responses to donor cells than DSA− patients. Furthermore, proliferating CD4+ T cells showed a marked increase in Th1 and Th17 responses in DSA+ patients than in DSA− patients. In a comparison between anti-donor and third-party responses, the anti-donor CD8+ and CD4+ T cell response was significantly lower than the anti-third-party response. In contrast, the donor-specific hyporesponsiveness was absent in DSA+ patients. Our study demonstrated that DSA+ recipients have a greater potential for developing immune responses against the donor tissues via the direct alloantigen recognition pathway. These data contribute to an understanding of DSAs pathogenicity during kidney transplantation

Development of R744 Two Stage Compressor for Commercial Heat Pump Water Heater

A novel CO2 two stage compressor has been developed. The developed compressor equips one rotary and one scroll compression chambers as first and second stage respectively. For efficiency improvement, authors measured the cylinder pressure in each stage and conducted loss classification in the compressor. By adopting appropriate compression type in each stage, and by decreasing critical loss found by measuring the pressure, it resulted in 6% and 10% improvement of heating capacity and COP respectively on rated condition, and 25% and over 50% improvement on deep-frozen condition compared with conventional single stage compressor. The developedcompressor is installed on our newly developed commercial heat pump water heater

Supercooled Jahn-Teller ice

When the spins on the frustrated pyrochlore lattice obey the celebrated 2-in-2-out ice rule, they stay in a correlated disordered phase and break the third law of thermodynamics. Similarly, if the atomic ions on the pyrochlore lattice move in and outward of the tetrahedra, they may obey a constraint resembling the ice rule. We discover that a model for pyrochlore molybdates A_{2}Mo_{2}O_{7} (A=Y, Dy, Tb) exhibits a “supercooled ice” state of the displacement degrees of freedom of Mo^{4+} ions, when we take account of the Jahn-Teller (JT) effect. The JT effect occurs when the lattice distortions reduce the symmetry of the local crystal field, resulting in the orbital-energy splitting that causes the local energy gain. Unlike the standard JT effect that leads to periodic long-range ordering, the displacements of Mo^{4+} ions are disordered following the icelike rule. We microscopically derive a model that describes this situation by having the 2nd- and 3rd-neighbor interactions between in-out lattice displacements comparably as strong as the nearest-neighbor interactions of standard ice. There, the well-known nearly flat energy landscape of the ice state is altered to a metastable highly quasidegenerate icelike liquid state coexisting with a crystalline-like ground state. Our Monte Carlo simulations show that this liquid remains remarkably stable down to low temperatures by avoiding the putative first-order transition. The relaxation in the supercooled JT ice state exhibits glassy dynamics with a plateau structure. They fit the feature of a “good glass former” very often found in molecular liquids but that has never been observed in material solids. The high glass-forming ability of the interacting lattice degrees of freedom will play a key role in the spin-glass transition of the material

Effects of Potassium Loading and Other Stimulating Conditions on the Glomerular Zone of Fetal Adrenal Cortex of Rats

Effects of several conditions known to stimulate the zona glomerulosa of the adrenal cortex in the adult were examined on the fetal adrenal cortex of rats histochemically and electron microscopically. The stimulating conditions were the following; administration of Na restricted diet to the mother, administration of KCl or angiotensin II to the fetus, spironolactone or insulin to the mother. In these, only an intraperitoneal injection of KCl solution to the fetus affected the fetal zona glomerulosa, in which increased activity of glucose-6-phosphate dehydrogenase and hyperfunctional alteration of the mitochondria and the smooth endoplasmic reticulum were observed. This fact shows the fetal glomerulosa cells can react to orae of the specific stimuli on the adult glomerulosa cells