Relationships between psychosocial characteristics and democratic values in Iranians: a cross-cultural study

This paper investigates the extent to which differences in people’s socio-political attitudes and behaviours are underpinned by individual characteristics. Two groups of volunteers: (a) an Iranian sample that have been resident in UK for less than two years, and (b) a British sample, took part in this study. A series of validated scales was used to examine differences in levels of empathy, theory of mind, flexibility, suggestibility, emotionality, openness, normative identity style, interpersonal trust, cooperativeness, emotionality, prosocial behaviour, egalitarian sex role, and authoritarianism between groups. Self-reported socio-political tendency, in terms of adherence to democracy, was also assessed. The results show significant differences in levels of these variables between the two cultural groups. Furthermore, the findings shed some light on the psychological and social factors that are related to democratic values and that predict this outcome in the two groups. Implications of the findings for policy makers and educational systems are discussed

Link between mindfulness and personality-related factors including empathy, theory of mind, openness, pro-social behaviour and suggestibility

This research investigated a potential linkage between mindfulness and personality characteristics such as openness to experience, empathy (empathic concern and theory of mind), prosocial behavior and suggestibility. A sample of 275 volunteers was recruited. A series of the research questionnaires and scales was employed to measure mindfulness, empathic concern, theory of mind (or perspective taking), prosocial behavior (or altruism) and suggestibility. Based on the quartile scores, participants were divided into two low (first quartile) and high (forth quartile) on mindfulness. Using a two-way MANOVA, the results showed that participants high on mindfulness exhibited increased theory of mind, prosocial behaviour and openness, in addition to decreased suggestibility. Neither main nor interaction effects were found for gender factor. Theoretical models in the field of social cognition will be discussed to explain how enhancement in cognitive functions due to mindfulness practice might alter personality characteristics and, in turn, influence socio-political behaviour

Bicultural Iranians’ political tendency: in between two cultures

The present study aimed to examine differences in a range of psychosocial variables and  political tendencies across three groups, namely Iranian new-comers (who have lived in the UK for less than two years), bicultural Iranians (born and raised in the UK or raised in the UK since they were under 10 years old), and UK citizens (bicultural participants were excluded). The target variables measured in the present study consisted of empathy, Theory of Mind (ToM), flexibility, suggestibility, openness to experiences, normative identity style, interpersonal trust, prosocial behaviour, egalitarian sex role, authoritarianism and adherence to democracy. A series of MANOVAs revealed significant main group effects for most of variables. The results of post hoc and polynomial tests yield an incremental linear trend on empathy, theory of mind, interpersonal trust, openness, prosocial behaviour and adherence to democratic values for groups ordered as Iranian new comers, bicultural and British; a decreasing trend was also observed on normative identity style, suggestibility, and authoritarianism. The between-two cultures’ findings of bicultural group might be explained by learning through political socialization. This provides support for the fact that being raised in a different cultural setting can have a vivid impact on people’s psychological characteristics and socio-political tendency

Problem-solving deficits in Iranian people with borderline personality disorder

Interventions for people suffering from borderline personality disorder (BPD), such as dialectical behavior therapy, often include a problem-solving component. However, there is an absence of published studies examining the problem-solving abilities of this client group in Iran. The study compared inpatients and outpatients with BPD and a control group on problem-solving capabilities in an Iranian sample. It was hypothesized that patients with BPD would have more deficiencies in this area. Fifteen patients with BPD were compared to 15 healthy participants. Means-ends problem-solving task (MEPS) was used to measure problem-solving skills in both groups. BPD group reported less effective strategies in solving problems as opposed to the healthy group. Compared to the control group, participants with BPD provided empirical support for the use of problem-solving interventions with people suffering from BPD. The findings supported the idea that a problem-solving intervention can be efficiently applied either as a stand-alone therapy or in conjunction with other available psychotherapies to treat people with BPD. OBJECTIVE METHODS RESULTS CONCLUSION

A psychophysiological investigation of laterality in human emotion elicited by pleasant and unpleasant film clips

<p>Abstract</p> <p>Background</p> <p>Research on laterality in emotion suggests a dichotomy between the brain hemispheres. The present study aimed to investigate this further using a modulated startle reflex paradigm.</p> <p>Methods</p> <p>We examined the effects of left and the right ear stimulation on the modulated startle reflex (as indexed by eyeblink magnitude, measured from the right eye) employing short (2 min) film clips to elicit emotions in 16 right-handed healthy participants. The experiment consisted of two consecutive sessions on a single occasion. The acoustic startle probes were presented monaurally to one of the ears in each session, counterbalanced across order, during the viewing of film clips.</p> <p>Results</p> <p>The findings showed that eyeblink amplitude in relation to acoustic startle probes varied linearly, as expected, from pleasant through neutral to unpleasant film clips, but there was no interaction between monaural probe side and foreground valence.</p> <p>Conclusions</p> <p>Our data indicate the involvement of both hemispheres when affective states, and associated startle modulations, are produced, using materials with both audio and visual properties. From a methodological viewpoint, the robustness of film clip material including audio properties might compensate for the insufficient information reaching the ipsilateral hemisphere when using static pictures. From a theoretical viewpoint, a right ear advantage for verbal processing may account for the failure to detect the expected hemispheric difference. The verbal component of the clips would have activated the left hemisphere, possibly resulting in an increased role for the left hemisphere in both positive and negative affect generation.</p

Exosomes derived from human mesenchymal stem cells preserve mouse islet survival and insulin secretion function

Islet cell death and loss of function after isolation and before transplantation is considered a key barrier to successful islet transplantation outcomes. Mesenchymal stem cells (MSCs) have been used to protect isolated islets owing to their paracrine potential partially through the secretion of vascular endothelial growth factor (VEGF). The paracrine functions of MSCs are also mediated, at least in part, by the release of extracellular vesicles including exosomes. In the present study, we examined (i) the effect of exosomes from human MSCs on the survival and function of isolated mouse islets and (ii) whether exosomes contain VEGF and the potential impact of exosomal VEGF on the survival of mouse islets. Isolated mouse islets were cultured for three days with MSC-derived exosomes (MSC-Exo), MSCs, or MSC-conditioned media without exosomes (MSC-CM-without-Exo). We investigated the effects of the exosomes, MSCs, and conditioned media on islet viability, apoptosis and function. Besides the expression of apoptotic and pro-survival genes, the production of human and mouse VEGF proteins was evaluated. The MSCs and MSC-Exo, but not the MSC-CM-without-Exo, significantly decreased the percentage of apoptotic cells and increased islet viability following the downregulation of pro-apoptotic genes and the upregulation of pro-survival factors, as well as the promotion of insulin secretion. Human VEGF was observed in the isolated exosomes, and the gene expression and protein production of mouse VEGF significantly increased in islets cultured with MSC-Exo. MSC-derived exosomes are as efficient as parent MSCs for mitigating cell death and improving islet survival and function. This cytoprotective effect was probably mediated by VEGF transfer, suggesting a pivotal strategy for ameliorating islet transplantation outcomes

Variation of ATM Gene Expression in Peripheral Blood Cells of Sporadic Breast Carcinomas in Iranian Patients

Abstract The ataxia telangiectasia mutated gene (ATM), candidate for breast cancer susceptibility gene, encode a 350-kDa protein belongs to the core components of DNA-damage response machinery. Female AT carriers have at least 5-fold increase risk for breast cancer. Reduction in ATM expression is shown in multiple studies in breast tissues. We aimed to perform a research to measure the ATM mRNA expression in peripheral blood cells in breast cancer patients. Peripheral blood sample from 40 newly diagnosed, histologically confirmed female breast cancer patients was collected before surgery. Total RNA was isolated from blood cells using the RNX-Plus solution and reverse transcribed into cDNA. Real-time PCR was performed using the 2 -∆∆CT method to calculate relative changes in gene expression by REST software. The Relative Quantitation (RQ) mean was 1.27 with the min. and max. equal to 0.20 and 3.34, respectively. Calculation of patient frequencies in different groups revealed that 17.5% had reduced expression lower than two fold decreases and 15% high expression more than two fold increases, but according to REST software there was no up-regulation or down-regulation compared to normal females. The findings of multiple studies consistent with this study indicate that the ATM gene may play an important role in breast cancer development and progression, and ATM expression is down-regulated in breast cancer tissues. Although, some of the results do not support a suppressor role for ATM in the development of sporadic breast cancer, 17.5% of our patients had under expression of ATM mRNA less than two fold relative to control

Effects of d-Amphetamine and Haloperidol on Modulation of the Human Acoustic Startle Response

"nObjective:This study aimed to examine the effects of haloperidol and amphetamine on human startle response modulated by emotionally-toned film clips. "n "n Method:Sixty participants, in two groups (one receiving haloperidol and the other receiving amphetamine) were tested using electromyography (EMG) to measure eye-blink muscle (orbicular oculi) while different emotions were induced by six 2-minute film clips. Results:An affective rating shows the negative and positive effects of the two drugs on emotional reactivity, neither amphetamine nor haloperidol had any impact on the modulation of the startle response. Conclusion: The methodological and theoretical aspects of the study and findings will be discussed