4 research outputs found
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
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- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
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- Alma Mater Studiorum University of Bologna)
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- Aou Sassari)
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- Argentina: Alurralde C.
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- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero â Universitaria di Bologna
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- TU Dresden)
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- Universiti Sains Malaysia)
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- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
- Vaz S. (Centro Hospitalar e UniversitĂĄrio de SĂŁo JoĂŁo)
- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
- Vernon L. (Cork University Hospital)
- Vervoort D.
- Vescio G. (University âMagna Graeciaâ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). RĂ©union: Kassir R.
- Vieira B. (Centro Hospitalar de TrĂĄs-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Ălvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- VĂĄzquez FernĂĄndez A. (Hospital ClĂnico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (Kingâs Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St Georgeâs Hospital)
- Wilson M. (Forth Valley Royal Hospital)
- Wimmer A. (Paracelsus Medical University Salzburg). Barbados: Barker D.
- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- YeĆilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19).
- Author
- Arribas José Ramón
- Berenguer Juan
- CarratalĂ Jordi
- Complejo Asistencial de Ăvila
- Complejo Hospitalario Universitario A Coruña
- Complejo Hospitalario Universitario de Ferrol
- Complejo Hospitalario Universitario Santa LucĂa
- Complejo Hospitalario Virgen de la Salud
- FundaciĂłn Hospital de Calahorra
- FundaciĂłn SEIMC-GESIDA
- Hospital Alto Deba
- Hospital CIMA-Sanitas
- Hospital ClĂnico San Cecilio
- Hospital ClĂnico Universitario de Valencia
- Hospital ClĂnico Universitario de Valladolid
- Hospital ClĂnico Universitario Lozano Blesa
- Hospital Comarcal de Blanes
- Hospital Costa del Sol
- Hospital de Barcelona SCIAS
- Hospital de Donostia
- Hospital de Guadalajara
- Hospital de Melilla
- Hospital de PalamĂłs
- Hospital de Sabadell (Parc Tauli)
- Hospital del Mar
- Hospital do Salnés
- Hospital Dos De Maig - Consorci Sanitari Integral
- Hospital FundaciĂłn JimĂ©nez DĂaz
- Hospital General de la Palma
- Hospital General Universitario Reina SofĂa
- Hospital Infanta Leonor
- Hospital Josep Trueta
- Hospital Juan Ramón Jiménez
- Hospital La Inmaculada
- Hospital Mutua de Terrassa
- Hospital Puerta de Hierro
- Hospital Regional de MĂĄlaga
- Hospital San Eloy de Barakaldo
- Hospital Son Espases
- Hospital Son Llatzer
- Hospital Universitari de Bellvitge
- Hospital Universitario Central de Asturias
- Hospital Universitario de Cruces
- Hospital Universitario de Getafe
- Hospital Universitario de Gran Canaria Dr NegrĂn
- Hospital Universitario de Jaén
- Hospital Universitario de Jerez
- Hospital Universitario de Valme
- Hospital Universitario de Ălava
- Hospital Universitario Gregorio Marañón
- Hospital Universitario Infanta Sofia
- Hospital Universitario La Paz
- Hospital Universitario los Arcos del Mar Menor
- Hospital Universitario Marqués de Valdecilla
- Hospital Universitario Puerto Real
- Hospital Universitario Rafael MĂ©ndez
- Hospital Universitario RamĂłn y Cajal
- Hospital Universitario San Pedro
- Hospital Universitario Severo Ochoa
- Hospital Universitario Virgen del RocĂo
- Hospital Universitario Virgen Macarena
- Hospital Universitario y Politécnico La Fe
- Hospital Vega Baja
- Hospital Virgen de la Arrixaca
- Hospital Ălvaro Cunqueiro
- JarrĂn Inmaculada
- PachĂłn JerĂłnimo
- Parc Sanitari Sant Joan de DĂ©u
- RodrĂguez-Baño JesĂșs
- Ryan Pablo
- SAM-COVID Study Group
- Yllescas MarĂa
- Publication venue
- 'Elsevier BV'
- Publication date
- 27/08/2020
- Field of study
The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situation
Intravenous immunoglobulin treatment for mild Guillain-Barré syndrome. An international observational study
- Author
- 2. Erasmus MC
- 2. KU Leuven
- 2. National and Kapodistrian University of Athens
- A. Davidson
- A. Doets
- A. Echaniz-Laguna
- A. J. van der Kooi
- A. Kohler
- A. Magot
- A. Pardal
- A. Savransky
- A. Schenone
- A. Spyropoulos (Royal Victoria Infirmary
- Aarhus Denmark)
- Aarhus Denmark)
- Allentown USA)
- Amsterdam
- Amsterdam
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Asturias Spain)
- Athens Greece)
- b) Dhaka
- b) Dhaka
- b) Dhaka
- B. Islam
- B. Stein
- B. van den Berg
- Baltimore USA)
- Bangladesh (icddr
- Bangladesh (icddr
- Bangladesh (icddr
- Bangladesh)
- Bangladesh)
- Bangladesh)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barroso F.
- Binda D.
- Bradford UK)
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Burlington
- Burlington VT
- C. Briani
- C. Bunschoten
- C. C. Chao
- C. Casasnovas
- C. Dornonville de la Cour
- C. Fokke
- C. G. Faber
- C. Homedes
- C. J. Gijsbers
- C. J. McDermott
- C. L. Sommer
- C. MĂĄrquez Infante
- C. Nascimbene
- C. Y. Tan
- Calgary Canada)
- Cambridge UK)
- Canada)
- Cape Town
- Cape Town
- Cavaletti G.
- Center
- Charlottesville USA)
- Chiba Japan)
- Chicago USA)
- Columbus USA)
- Copenhagen Denmark)
- Cordoba Spain)
- Cornblath D. R.
- Delft
- Department of Medicine
- Department of Medicine
- Dhaka Bangladesh)
- DO (Lehigh Valley Health Network
- DO (Spectrum Health System
- Dordrecht
- Dordrecht
- E. Dardiotis
- E. H. Niks
- E. Lee Pan
- E. Martinez Hernandez
- E. Nobile Orazio
- F. Eftimov
- F. Vermeij
- Faculty of Medicine
- Faculty of Medicine
- Fayetteville USA)
- FLENI
- France)
- France)
- FRCP (Ipswich Hospital
- FRCP (The Walton Centre
- G. A. Marfia
- G. Antonini
- G. Chavada
- G. Gutiérrez-Gutiérrez
- G. M. Sachs
- G. Mataluni
- G. Meekins
- G. MorĂs de la Tassa
- G. W. van Dijk
- Galassi G.
- Genetics and Maternal and Infantile Sciences (DINOGMI)
- Genova
- Genova Italy)
- Glasgow UK)
- Glasgow UK)
- Glasgow UK)
- Glostrup Denmark)
- Gorson K. C.
- Grand Rapids
- H. D. Katzberg
- H. J. Willison
- H. Kerkhoff
- H. Manji
- H. Tankisi
- Harbo T.
- Helmond and Deurne
- Homburg Germany)
- Homburg Germany)
- Hoorn
- Hospital Clinic
- Hospital of Larissa
- Houston USA)
- Hughes R. A. C.
- Humanitas Clinicala and Research Institute Milan
- Humanitas Clinicala and Research Institute Milan
- I. Illa
- I. Jahan
- I. JericĂł Pascual
- I. R. Bella
- I. Rojas-Marcos
- Indianapolis USA)
- Ipswich UK)
- Irvine USA)
- Italy 2. IRCCS Policlinico San Martino
- Italy)
- Italy)
- Italy)
- Italy)
- J. A. L. Miller
- J. BuÌrmann
- J. D. Varrato
- J. Fehmi (University of Oxford E. A. Fulgenzi
- J. Gilhuis
- J. K. L. Holt
- J. M. Gilchrist
- J. M. Goldstein
- J. Pardo Fernandez (Hospital ClĂnico de Santiago
- J. Roodbol
- J. S. Cosgrove
- J. V. Holbech
- J. Y. Kwan
- Jacksonville USA)
- Jacobs B. C. H. Andersen
- K. Bateman
- K. G. Claeys
- K. Jellema
- K. Kaida
- K. Kimpinski
- K. Kuitwaard
- K. Sheikh
- Kansas City
- Kusunoki S.
- Kuwabara S.
- L. Benedetti
- L. H. Visser
- L. Kiers
- L. Landschoff Lassen
- L. MartĂn-Aguilar
- L. Querol Gutierrez
- L. Santoro
- L. Schwindling
- L. Zhou
- La Spezia
- La Spezia
- Larissa Greece)
- Leeds UK)
- Lehmann H. C.
- Leiden
- Leiden
- Leuven Belgium
- Leuven Belgium)
- Leuven Belgium)
- Leuven Belgium)
- LHSC London-Ontario
- Liverpool UK)
- London UK)
- London UK)
- Lunn M. P.
- M. Bianco (Milan University
- M. Busby
- M. C. Dalakas
- M. Derejko
- M. E. Conti
- M. G. Mattiazzi
- M. Htut
- M. J. Sedano Tous
- M. Kuwahara
- M. M. Dimachkie
- M. Mandarakas
- M. Osei-Bonsu
- M. P. J. Garssen
- M. Pulley
- M. S. Monges
- M. Samukawa
- M. V. Vytopil
- M. van Woerkom (Erasmus MC
- Maastricht
- Malaya)
- Malaya)
- Marseille France)
- MBChB
- MBChB (Groote Schuur Hospital
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD (1. Thomas Jefferson University
- MD (Addenbrookeâs Hospital Cambridge
- MD (Barrow Neurology Clinics
- MD (Bellvitge University Hospital - IDIBELL Neurometabolic Diseases Group. CIBERER
- MD (BicĂȘtre University Hospital
- MD (Buffalo Jacobs School of Medicine S. Sindrup
- MD (Canisius Wilhelmina Hospital
- MD (Columbia University
- MD (Dokkyo Medical University
- MD (Franciscus Gasthuis
- MD (Franciscus Gasthuis
- MD (Gelre Hospital
- MD (Glostrup Hospital
- MD (Hospital Britanico
- MD (Hospital Cesar Milstein Buenos Aires
- MD (Hospital ClĂnico de Santiago
- MD (Hospital de la Santa Creu i Sant Pau
- MD (Hospital de PediatrĂa J. P. Garrahan
- MD (Hospital Militar Central
- MD (Hospital Universitario Infanta Sofia
- MD (Hospital Universitario Marques de Valdecilla
- MD (Hospital Universitario Virgen del Rocio
- MD (Hospital UniversitarioCentral de Asturias
- MD (Hospital Univesitario Reina Sofia
- MD (Institut dâInvestigacions BiomĂšdiques August Pi i Sunyer (IDIBAPS)
- MD (Instituto de Investigaciones NeurolĂłgicas RaĂșl Carrea
- MD (Leeds General Infirmary
- MD (Leeds General Infirmary
- MD (Maasstad Hospital
- MD (Mental Health and Sensory Organs (NESMOS)
- MD (Montefiore Medical
- MD (National Hospital Copenhagen
- MD (Neurological Clinic
- MD (Neurology Unit
- MD (Northwestern University Feinberg
- MD (Odense University Hospital
- MD (Ospedale Santâ Andrea La Spezia
- MD (Pinderfields Hospital
- MD (Reference Centre for NMD
- MD (Royal Hallamshire Hospital
- MD (Scientific Institute San Raffaele
- MD (Soulthern Illinois University School of Medicine
- MD (St. Georgeâs Hospital
- MD (St. Josephâs Regional Medical Center
- MD (The University of Tennessee Health Science Center (UTHSC)
- MD (Toho University Medical Center
- MD (University Hospital
- MD (University Hospital Clinicas
- MD (University Hospital/ University of Texas Health Science Center
- MD (University of Arkansas
- MD (University of Calgary
- MD (University of California
- MD (University of Florida
- MD (University of Glasgow
- MD (University of Indiana School of Medicine
- MD (University of Kansas Medical Center
- MD (University of Maryland School of Medicine
- MD (University of Mass Medical School
- MD (University of Melbourne
- MD (University of Minnesota
- MD (University of Padova
- MD (University of Rhode Island
- MD (University of Thessaly
- MD (University of Toronto
- MD (University of Utah School of Medicine
- MD (University of Vermont
- MD (University of Vermont Medical Center
- MD (University of Virginia
- MD (UniversitÀtsklinikum des Saarlandes
- MD (UniversitÀtsklinikum des Saarlandes
- MD (UniversitĂ€tsklinikum WuÌrzburg
- MD (Vlietland Hospital
- MD (Westfriesgasthuis
- MD (Wexner Medical Center at The Ohio State University
- MD (Yale University School of Medicine
- MD (Yale University School of Medicine
- Memphis USA)
- Middlesbrough UK)
- Milan Italy)
- Milan Italy)
- MRCP (Neurology Unit
- N. A. Goyal
- N. J. Silvestri
- N. Kokubun
- N. Kolb
- N. Shahrizaila
- Nantes University Hospital
- Nantes University Hospital
- Napels Italy)
- New Brunswick
- New Haven
- New Haven
- New York
- New York City
- Newcastle UK)
- Newcastle UK)
- NIHR Clinical
- Nijmegen
- Odense Denmark)
- Odense Denmark)
- Odense Denmark)
- Osaka Japan)
- Osaka Japan)
- P. Twydell
- P. Van Damme
- P. Van den Bergh
- Padova Italy)
- Pamplona Spain)
- Paris France)
- Parkville Australia)
- Paterson USA)
- PhD
- PhD (1. Albert Schweitzer Hospital
- PhD (1. Department of Neurosciences
- PhD (1. University Hospitals Leuven
- PhD (Aarhus University Hospital
- PhD (Aarhus University Hospital
- PhD (Albert Schweitzer Hospital
- PhD (Amsterdam University Medical Centre
- PhD (Amsterdam University Medical Centre
- PhD (Bellvitge University Hospital - IDIBELL Neurometabolic Diseases Group. CIBERER
- PhD (Chiba University
- PhD (CHU Timone
- PhD (Complejo Hospitalario de Navarra
- PhD (Concord Repatriation General Hospital
- PhD (Elisabeth-TweeSteden Hospital
- PhD (Elkerliek Hospital
- PhD (Erasmus University Medical Centre
- PhD (Glasgow University
- PhD (Groote Schuur Hospital
- PhD (Haaglanden Medisch Centrum
- PhD (HagaZiekenhuis
- PhD (Hospital de la Santa Creu i Sant Pau
- PhD (Hospital de la Santa Creu i Sant Pau
- PhD (Hospital de PediatrĂa J. P. Garrahan
- PhD (Icahn School
- PhD (International Centre for Diarrhoeal Disease Research
- PhD (International Centre for Diarrhoeal Disease Research
- PhD (James Cook University Hospital
- PhD (Jeroen Bosch Hospital
- PhD (Kindai University
- PhD (Kindai University
- PhD (Kingâs College Hospital
- PhD (Leiden University Medical Centre
- PhD (Leiden University Medical Centre
- PhD (Luigi Sacco Hospital
- PhD (Maastricht University Medical Centre
- PhD (Milan University
- PhD (National Defense Medical College
- PhD (National Institute of Neurosciences and Hospital
- PhD (National Taiwan University Hospital
- PhD (National Taiwan University Hospital
- PhD (Neurological Clinic
- PhD (Odense University Hospital
- PhD (Odense University Hospital
- PhD (Ospedale Santâ Andrea La Spezia
- PhD (Reference Centre for NMD
- PhD (Reinier de Graaf Gasthuis
- PhD (Royal Victoria Infirmary
- PhD (Rutgers
- PhD (The University of Texas Health Science Center at Houston
- PhD (Tufts University School of Medicine Lahey Hospital P. W. Wirtz
- PhD (University Clinic St. Luc
- PhD (University Federico II
- PhD (University Hospital Leuven
- PhD (University of Glasgow
- PhD (University of Oxford J. P. A. Samijn
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (International Centre for Diarrhoeal Disease Research
- Philadelphia USA
- Phoenix Arizona
- Policlinico Tor Vergata
- Policlinico Tor Vergata
- Providence USA)
- Q. D. Mohammad
- R. Bhavaraju-Sanka
- R. C. Roberts
- R. D. M. Hadden
- R. Fazio
- R. J. Nowak
- R. M. Pascuzzi
- R. van Koningsveld
- Rehabilitation Ophthalmology
- Reisin R. C.
- Robert Wood Johnson University Hospital
- Rome Italy)
- Rome Italy)
- Rome Italy)
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Royal Melbourne Hospital
- S. A. Rudnicki
- S. Ajroud-Driss
- S. Attarian
- S. Butterworth
- S. Chen
- S. E. Leonhard
- S. Grisanti
- S. Karafiath
- S. Rinaldi
- S. S. Ladha
- S. T. Hsieh
- S. W. Reddel
- Saitama Japan)
- Salt Lake City
- San Antonio Texas
- San Sebastian
- Santander Cantabria
- Santiago de Compostela (A Coruña)
- Santiago de Compostela (A Coruña)
- SantâAndrea Hospital
- Sapienza University
- Schiedam
- Seville Spain)
- Sheffield UK)
- South-Africa)
- South-Africa)
- Spain)
- Spain)
- Spain)
- Spain)
- Springfield USA)
- Sydney Australia)
- T. E. Bertorini
- T. E. Feasby
- T. Fujioka
- T. GarcĂa-Sobrino
- T. H. Brannagan
- T. van der Ree
- Taipei Taiwan)
- Taipei Taiwan)
- The Hague
- The Hague
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- the Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- the Netherlands)
- the Netherlands)
- The Netherlands)
- the Netherlands)
- The Netherlands)
- the Netherlands)
- Tilburg and Waalwijk
- Tochigi Japan)
- Tokyo Japan)
- Toronto Canada)
- U. A. Badrising
- Universitat AutĂČnoma de Barcelona
- Universitat AutĂČnoma de Barcelona
- Universitat AutĂČnoma de Barcelona
- University of Genova
- University of Malaya
- University of Malaya
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA). Other collaborators were:J. M. Addington
- V. Granit
- V. Lawson
- Van Doorn P. A.
- Verboon C.
- W. Waheed
- Wakefield UK)
- Worcester USA)
- WuÌrzburg Germany)
- Y. Péréon
- Y. Sekiguchi
- Z. Islam
- Zutphen and Apeldoorn
- âs Hertogenbosch
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2021
- Field of study
Objective: To compare the disease course in patients with mild Guillain-Barré syndrome (GBS) who were treated with intravenous immunoglobulin (IVIg) or supportive care only. Methods: We selected patients from the prospective observational International GBS Outcome Study (IGOS) who were able to walk independently at study entry (mild GBS), treated with one IVIg course or supportive care. The primary endpoint was the GBS disability score four weeks after study entry, assessed by multivariable ordinal regression analysis. Results: Of 188 eligible patients, 148 (79%) were treated with IVIg and 40 (21%) with supportive care. The IVIg group was more disabled at baseline. IVIg treatment was not associated with lower GBS disability scores at 4 weeks (adjusted OR (aOR) 1.62, 95% CI 0.63 to 4.13). Nearly all secondary endpoints showed no benefit from IVIg, although the time to regain full muscle strength was shorter (28 vs 56 days, p=0.03) and reported pain at 26 weeks was lower (n=26/121, 22% vs n=12/30, 40%, p=0.04) in the IVIg treated patients. In the subanalysis with persistent mild GBS in the first 2 weeks, the aOR for a lower GBS disability score at 4 weeks was 2.32 (95% CI 0.76 to 7.13). At 1 year, 40% of all patients had residual symptoms. Conclusion: In patients with mild GBS, one course of IVIg did not improve the overall disease course. The certainty of this conclusion is limited by confounding factors, selection bias and wide confidence limits. Residual symptoms were often present after one year, indicating the need for better treatments in mild GBS
Second IVIg course in Guillain-Barré syndrome with poor prognosis. The non-randomised ISID study
- Author
- 0:1â9. doi:10. 1136/jnnp-2019-321496 Neuromuscular Ajroud-Driss
- 2. KU Leuven
- 2. National and Kapodistrian University of Athens
- 2019 at Uppsala Universitet BIBSAM http://jnnp. bmj. com/ J Neurol Neurosurg Psychiatry: first published as 10. 1136/jnnp-2019-321496 on 5 October 2019. Downloaded from 8 Verboon C
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- USA). Other collaborators were:U. A. Badrising
- V. Granit
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- Van Doorn P. A. J. M. Addington
- Venema E.
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- Publication venue
- 'BMJ'
- Publication date
- 01/01/2020
- Field of study
Objective To compare disease course in patients with Guillain-Barré syndrome (GBS) with a poor prognosis who were treated with one or with two intravenous immunoglobulin (IVIg) courses. Methods From the International GBS Outcome Study, we selected patients whose modified Erasmus GBS Outcome Score at week 1 predicted a poor prognosis. We compared those treated with one IVIg course to those treated with two IVIg courses. The primary endpoint, the GBS disability scale at 4 weeks, was assessed with multivariable ordinal regression. Results Of 237 eligible patients, 199 patients received a single IVIg course. Twenty patients received an α early' second IVIg course (1-2 weeks after start of the first IVIg course) and 18 patients a α late' second IVIg course (2-4 weeks after start of IVIg). At baseline and 1 week, those receiving two IVIg courses were more disabled than those receiving one course. Compared with the one course group, the adjusted OR for a better GBS disability score at 4 weeks was 0.70 (95%CI 0.16 to 3.04) for the early group and 0.66 (95%CI 0.18 to 2.50) for the late group. The secondary endpoints were not in favour of a second IVIg course. Conclusions This observational study did not show better outcomes after a second IVIg course in GBS with poor prognosis. The study was limited by small numbers and baseline imbalances. Lack of improvement was likely an incentive to start a second IVIg course. A prospective randomised trial is needed to evaluate whether a second IVIg course improves outcome in GBS