Crystal structure of (1R,2R)-trans-1,2-cyclohexanedicarhoxylic acid-(R)- 1-phenylethylamine salt

金沢大学大学院自然科学研究科先端機能物質金沢大学工学

Effects of dipole interaction and solvation on the C=O stretching band of N,N-dimethylacetamide in nonpolar solutions: Infrared, isotropic and anisotropic Raman measurements

The concentration dependence of the C=O stretching (nu(C=O)) band of N,N-dimethylacetamide (NdMA) in cyclohexane, n-hexane, and CCl4 has been investigated by infrared (IR) and polarized Raman spectroscopy. For the neat liquid of NdMA, the noncoincidence of the aniso- and isotropic Raman wavenumbers is evident. In the 0.47 M cyclohexane solution of NdMA, the noncoincidence effect almost disappears and the nu(C=O) envelopes in both the Raman and IR spectra are asymmetric to the low-wavenumber side. When the concentration of NdMA decreases from 0.33 to 0.023 M. the peak of these bands slightly shifts to a higher wavenumber and the band shape becomes symmetric. The shape of the nu(C=O) envelope does not show any significant change below 0.023 M. These results Suggest that the asymmetric shape of the nu(C=O) band observed for the 0.33 M cyclohexane solution is associated with the intermolecular interaction among NdMA molecules, which vanishes at around 0.02 M. Spectral changes for the CCl4 solution of NdMA show a similar tendency. However, the shape and peak wavenumber of the nu(C=O) band observed in a highly diluted CCl4 solution (<= 0.023 M) indicate that the solvation effect of CCl4 is more complicated than those of cyclohexane and n-hexane. The analyses of the nu(C=O) band, which is sensitive to the intermolecular interaction between Solutes and between Solute and solvent for NdMA dissolved in nonpolar solvents. Would serve to clarify the electronic property of the molecule in a solution

Estrogenic/Antiestrogenic Activities of Quinoid Polycyclic Aromatic Hydrocarbons

Estrogenic and antiestrogenic activities of 19 quinoid polycyclic aromatic hydrocarbons (PAHQs) and 9 ketone PAHs were evaluated by the yeast two-hybrid assay using yeast cells expressing estrogen receptor-α (ERα). Binding affinity of PAHQs to ERα was assayed by the polarized fluorescence method using FluormoneTM ES2. Ten PAHQs having 3-5 rings showed antiestrogenic activities. The most strongly antiestrogenic PAHQs were 1,4-chrysenequinone and 5,6-chrysenequinone. On the other hand, benzo[a]pyrene-3,6-quinone showed the strongest estrogenic activity. However, the other compounds tested did not show so strong estrogenic/antiestrogenic activities. Binding affinity to ER was required but not sufficient for estrogenic/antiestrogenic activities of PAHQs. The length-to-breadth ratios of the rectangular planes surrounding the ring molecules and the distances between the oxygen atom of the carbonyl group and farthest hydrogen atom of estrogenic/antiestrogenic PAHQs were in narrow ranges, suggesting a structure-activity relationship. As interactions between active PAHQ and ER, hydrogen bonding between carbonyl groups and amino acid residues and van der Waals forces were considered

Synthesis and nematocidal activity of diarylnonanoids related to malabaricones

Twenty diarylnonanones were synthesized and their nematocidal activity was examined. Among those, the p-hydroxy compound 16 exhibited the strongest activity comparable to the natural diarylnonanoids, malabaricones A and C. Diarylundecanoid 57 also showed appreciable activity