Binding tactile and visual sensations via unique association by cross-anchoring between double-touching and self-occlusion

Binding is one of the most fundamental cognitive functions, how to find the correspondence of sensations between different modalities such as vision and touch. Without a priori knowledge on this correspondence, binding is regarded to be a formidable issue for a robot since it often perceives multiple physical phenomena in its different modal sensors, therefore it should correctly match the foci of attention in different modalities that may have multiple correspondences each other. We suppose that learning the multimodal representation of the body should be the first step toward binding since the morphological constraints in self-body-observation would make the binding problem tractable. The multimodal sensations are expected to be constrained in perceiving own body so as to configurate the unique parts of the multiple correspondence reflecting its morphology. In this paper, we propose a method to match the foci of attention in vision and touch through the unique association by cross-anchoring different modalities. Simple experiments show the validity of the proposed method

How does an infant acquire the ability of joint attention?: A Constructive Approach

This study argues how a human infant acquires the ability of joint attention through interactions with its caregiver from the viewpoint of a constructive approach. This paper presents a constructive model by which a robot acquires a sensorimotor coordination for joint attention based on visual attention and learning with self-evaluation. Since visual attention does not always correspond to joint attention, the robot may have incorrect learning situations for joint attention as well as correct ones. However, the robot is expected to statistically lose the data of the incorrect ones as outliers through the learning, and consequently acquires the appropriate sensorimotor coordination for joint attention even if the environment is not controlled nor the caregiver provides any task evaluation. The experimental results suggest that the proposed model could explain the developmental mechanism of the infant’s joint attention because the learning process of the robot’s joint attention can be regarded as equivalent to the developmental process of the infant’s one

A Constructive Model of Mother-Infant Interaction towards Infant’s Vowel Articulation

Human infants seem to develop to acquire common phonemes to adults without the capability to articulate or any explicit knowledge. To understand such unrevealed human cognitive development, building a robot which reproduces such a developmental process seems effective. It will also contribute to a design principle for a robot that can communicate with human beings. This paper hypothesizes that the caregiver’s parrotry to the coo of the robot plays an important role in the phoneme acquisition process based on the implication from behavioral studies, and propose a constructive model for it. We validate the proposed model by examining whether a real robot can acquire Japanese vowels through interactions with its caregiver

Body Scheme Acquisition by Cross Modal Map Learning among Tactile, Visual, and Proprioceptive Spaces

How to represent own body is one of the most interesting issues in cognitive developmental robotics which aims to understand the cognitive developmental processes that an intelligent robot would require and how to realize them in a physical entity. This paper presents a cognitive model how the robot acquires its own body representation, that is body scheme for the body surface. The internal observer assumption makes it difficult for a robot to associate the sensory information from different modalities because of the lacking of references between them that are usually given by the designer in the prenatal stage of the robot. Our model is based on cross-modal map learning among join, vision, and tactile sensor spaces by associating different pairs of sensor values when they are activated simultaneously. We show a preliminary experiment, and then discuss how our model can explain the reported phenomenon on body scheme and future issues

Early endovascular stenting for extracranial carotid artery dissection with angiographic flow stasis: A series of four cases

Extracranial carotid artery dissection is a major cause of ischemic stroke in young patients. Progressive stroke or recurrent ischemic symptoms may occur despite adequate medical treatment. Our treatment policy for these conditions is based on the fact that immediate vascular reconstruction is necessary in the cases with angiographic flow stasis in the true lumen beyond the dissection site. We report our experiences with four consecutive extracranial carotid artery dissections successfully treated with early endovascular stenting and discuss the indication of this treatment with a special emphasis on the angiographic findings

Individual Radiation Exposure Dose Due to Support Activities at Safe Shelters in Fukushima Prefecture

Immediately after the accidents in the nuclear power stations in Fukushima on March 11, the Japanese Government ordered the evacuation of the residents within a 20-km radius from the station on March 12, and asked various institutions to monitor the contamination levels of the residents. Hirosaki University, which is located 355 km north of Fukushima City, decided to send support staff to Fukushima. This report summarizes the results of the exposure of 13 individual teams from March 15 to June 20. The support teams surveyed more than 5,000 people during this period. Almost all subjects had external contamination levels of less than 13 kcpm on Geiger-Müller (GM) survey meter, which is categorized as “no contamination level.” The 1st team showed the highest external exposure dose, but the 4th team onward showed no significant change. Subsequently, the internal radiation exposure was measured using a whole body counter that indicated undetectable levels in all staff members. Although the measured external radiation exposure dose cannot have serious biological effects on the health of an individual, a follow-up study of the residents in Fukushima and other regions where the radioactive material has spread will be required for a long time

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target