An Analytical Solution to the One-Dimensional Heat Conduction–Convection Equation in Soil

Soil heat transfer occurs by conduction and convection. Soil temperatures below infiltrating water can provide a signal for water flux. In earlier work, analysis of field measurements with a sine wave model indicated that convection heat transfer made significant contributions to the subsurface temperature oscillations. In this work, we used a Fourier series to describe soil surface temperature variations with time. The conduction and convection heat transfer equation with a multi-sinusoidal wave boundary condition was solved analytically using a Fourier transformation. Soil temperature values calculated by the single sine wave model and by the Fourier series model were compared with field soil temperature values measured at depths of 0.1 and 0.3 m below an infiltrating ponded surface. The Fourier series model provided better estimates of observed field temperatures than the sine wave model. The new model provides a general way to describe soil temperature under an infiltrating water source

Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?

BACKGROUND: There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 & HLA-Cw*0702 had been suggested by our previous, small study. METHODS: We studied the HLA-B & C alleles in 196 cases of 'definite' or 'probable' AD and 199 elderly controls of the OPTIMA cohort, the largest full study of these alleles in AD to date. RESULTS: We replicated the association of HLA-B7 with AD (overall, adjusted odds ratio = 2.3, 95% confidence interval = 1.4–3.7, p = 0.001), but not the previously suggested interaction with the ε4 allele of apolipoprotein E. Results for HLA-Cw*0702, which is in tight linkage disequilibrium with HLA-B7, were consistent with those for the latter. Homozygotes of both alleles appeared to be at particularly high risk of AD. CONCLUSION: HLA-B7 and HLA-Cw*0702 are associated with AD in the Oxford population. Because of the contradictions between cohorts in our previous study, we suggest that these results may be geographically specific. This might be because of differences between populations in the structure of linkage disequilibrium or in interactions with environmental, genetic or epigenetic factors. A much larger study will be needed to clarify the role of homozygosity of HLA alleles in AD risk