Metabolic interventions in acute myocardial infarction

This thesis is a new branch on the large tree of studies on optimal therapeutic strategy for and understanding of ST segment elevation MI. In 1989, the Zwolle Myocardial Infarction Study Group performed its first study of comparing PCI with streptokinase. Thereafter studies on the effect of primary PCI, stenting, intra-aortic balloon counterpulsation, prehospital treatment with heparin and glycoprotein IIb/IIIa receptor blockers have been reported. Over the last years more research has been done to investigate the causative mechanisms behind favorable and unfavorable outcome after treatment with primary PCI. Currently, special emphasis is given to the effect of glucose derangements and patients with diabetes mellitus. The concept to add a metabolic intervention to the treatment strategy of primary PCI was formulated in 1997. The purpose of this thesis is to investigate the effect of metabolic interventions and disturbances on the clinical outcome and myocardial function in ST segment elevation MI patients.

Search for Scalar Diphoton Resonances in the Mass Range 65−60065-600 GeV with the ATLAS Detector in pppp Collision Data at s\sqrt{s} = 8 TeVTeV

A search for scalar particles decaying via narrow resonances into two photons in the mass range 65–600 GeV is performed using $20.3\text{}\text{}{\mathrm{fb}}^{-1}$ of $\sqrt{s}=8\text{}\text{}\mathrm{TeV}$ $pp$ collision data collected with the ATLAS detector at the Large Hadron Collider. The recently discovered Higgs boson is treated as a background. No significant evidence for an additional signal is observed. The results are presented as limits at the 95% confidence level on the production cross section of a scalar boson times branching ratio into two photons, in a fiducial volume where the reconstruction efficiency is approximately independent of the event topology. The upper limits set extend over a considerably wider mass range than previous searches