5 research outputs found
A Thiazolidinedione Improves In Vivo Insulin Action on Skeletal Muscle Glycogen Synthase in Insulin-Resistant Monkeys
Thiazolidinediones (TZD) have been shown to have
anti-diabetic effects including the ability to decrease
fasting hyperglycemia and hyperinsulinemia, increase
insulin-mediated glucose disposal rate (M)
and decrease hepatic glucose production, but the
mechanisms of action are not well established. To
determine whether a TZD (R-102380, Sankyo Company
Ltd., Tokyo, Japan) could improve insulin
action on skeletal muscle glycogen synthase (GS),
the rate-limiting enzyme in glycogen synthesis, 4
insulin-resistant obese monkeys were given I mg/kg/
day R-102380 p.o. for a 6-week period. Skeletal
muscle GS activity and glucose 6-phosphate (G6P)
content were compared between pre-dosing and
dosing periods before and during the maximal
insulin-stimulation of a euglycemic hyperinsulinemic
clamp